Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ | R | → |
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+ | null |
• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.
ER | Cis- | Medial- | Trans- | TGN |
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UGT2B4/hsa-miR-1277-5p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'... UAUUUAUAUAUAAU
AUAUAUUA
...
3' UAUGCAUGUAUAUAUA UAUAUAA A |
8mer | 1176-1183 | -0.315 | 99.0 | -0.001 | 44.0 | noncon | |
5'... CACUACAUAUGUAU
AUAUAUU
U...
3' UAUGCAUGUAUAUAUA UAUAUAA A |
7mer-m8 | 3253-3259 | -0.212 | 98.0 | 0.0 | 43.0 | noncon | |
5'... UAAAUAUUAUAUAU
AUAUAUU
U...
3' UAUGCAUGUAUAUAUA UAUAUAA A |
7mer-m8 | 3231-3237 | -0.172 | 97.0 | 0.0 | 42.0 | noncon | |
5'... UUCAUUGGCGUUUA
AUAUAUU
U...
3' UAUGCAUGUAUAUAUA UAUAUAA A |
7mer-m8 | 4582-4588 | -0.112 | 94.0 | 0.0 | 41.0 | noncon | |
5'... GUGUGUGUAUAUAU
AUAUAUU
C...
3' UAUGCAUGUAUAUAUA UAUAUAA A |
7mer-m8 | 1127-1133 | -0.102 | 93.0 | 0.0 | 41.0 | noncon | |
5'... UGCUCUGUUAUUAC
AUAUAUU
C...
3' UAUGCAUGUAUAUAUA UAUAUAA A |
7mer-m8 | 4890-4896 | -0.099 | 93.0 | 0.0 | 41.0 | noncon |