GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT1



General Information
Gene Symbol:   
GALNT1
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• ppGalNAc-T1 is localized throughout the Golgi
• Mutations in ppGalNAcT activity can result in various diseases.
• ppGalNAc-T2 and ppGalNAc-T3 were more abundant in the trans and medial Golgi.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-6811436
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q10472 
NCBI GeneID:   
2589
GlyMap GeneID:   
2589
DNA aRefSeq:   
NM_020474.3 
Protein RefSeq:   
NP_065207.2 
BRENDA:   
Kinetic info.
OMIM number:   
602273
GeneCards database:   
GALNT1
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 50 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-892b 420-427 -0.585 99.0 -0.577 99.0 noncon
hsa-miR-5195-3p 455-462 -0.53 99.0 -0.523 99.0 con
hsa-miR-5089-3p 76-83 -0.512 99.0 -0.512 99.0 noncon
hsa-miR-145-5p 455-462 -0.452 99.0 -0.446 99.0 con
hsa-miR-8060 3609-3616 -0.447 99.0 0.0 0.0 noncon
hsa-miR-653-3p 2391-2398 -0.437 99.0 -0.002 49.0 noncon
hsa-miR-4458 44-51 -0.429 96.0 -0.429 97.0 con
hsa-miR-10b-5p 518-524 -0.422 99.0 -0.382 99.0 con
hsa-miR-10a-5p 518-524 -0.422 99.0 -0.382 99.0 con
hsa-let-7d-5p 44-51 -0.421 96.0 -0.421 97.0 con
hsa-miR-4286 606-613 -0.419 99.0 -0.379 99.0 noncon
hsa-let-7i-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-miR-98-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-let-7f-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-let-7c-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-let-7e-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-miR-4500 44-51 -0.411 96.0 -0.411 97.0 con
hsa-let-7a-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-let-7g-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-let-7b-5p 44-51 -0.411 96.0 -0.411 97.0 con
hsa-miR-3907 3081-3088 -0.407 97.0 -0.002 25.0 noncon
hsa-miR-16-5p 1187-1193 -0.402 98.0 -0.338 97.0 con
hsa-miR-202-3p 599-606 -0.399 97.0 -0.361 98.0 noncon
hsa-miR-7160-5p 47-54 -0.396 99.0 -0.396 99.0 noncon
hsa-miR-15b-5p 1187-1193 -0.391 98.0 -0.329 97.0 con
hsa-miR-15a-5p 1187-1193 -0.391 98.0 -0.329 97.0 con
hsa-miR-195-5p 1187-1193 -0.391 98.0 -0.329 97.0 con
hsa-miR-6874-3p 541-548 -0.386 99.0 -0.35 99.0 noncon
hsa-miR-148b-5p 541-548 -0.383 99.0 -0.347 99.0 noncon
hsa-miR-3065-3p 686-693 -0.373 98.0 -0.338 98.0 noncon
hsa-miR-6838-5p 1187-1193 -0.37 98.0 -0.312 97.0 con
hsa-miR-4797-3p 275-282 -0.37 99.0 -0.37 99.0 noncon
hsa-miR-2116-3p 1943-1950 -0.367 99.0 -0.014 68.0 noncon
hsa-miR-424-5p 1187-1193 -0.366 97.0 -0.308 97.0 con
hsa-miR-549a 1380-1387 -0.364 97.0 -0.014 40.0 noncon
hsa-miR-30b-5p 228-235 -0.36 97.0 -0.36 98.0 con
hsa-miR-30c-5p 228-235 -0.36 97.0 -0.36 98.0 con
hsa-miR-6832-5p 739-746 -0.352 97.0 -0.317 97.0 noncon
hsa-miR-4423-3p 1565-1572 -0.352 97.0 -0.013 44.0 noncon
hsa-miR-30e-5p 228-235 -0.352 97.0 -0.352 98.0 con
hsa-miR-335-3p 285-292 -0.352 99.0 -0.352 99.0 noncon
hsa-miR-6514-5p 1117-1124 -0.35 98.0 -0.295 98.0 noncon
hsa-miR-6796-5p 3149-3156 -0.348 96.0 -0.002 25.0 noncon
hsa-miR-367-5p 3233-3240 -0.348 97.0 -0.002 37.0 noncon
hsa-miR-137 999-1006 -0.347 95.0 -0.312 95.0 con
hsa-miR-30a-5p 228-235 -0.344 97.0 -0.344 97.0 con
hsa-miR-497-5p 1187-1193 -0.344 97.0 -0.29 96.0 con
hsa-miR-30d-5p 228-235 -0.344 97.0 -0.344 97.0 con
hsa-miR-4303 1847-1854 -0.344 98.0 -0.013 64.0 noncon
hsa-miR-2467-3p 104-111 -0.334 97.0 -0.334 98.0 noncon
hsa-miR-503-3p 956-963 -0.327 96.0 -0.294 96.0 noncon
hsa-miR-3200-5p 1125-1132 -0.324 98.0 -0.274 98.0 noncon
hsa-miR-433-3p 474-481 -0.324 98.0 -0.294 98.0 con
hsa-miR-6852-5p 1717-1724 -0.324 97.0 -0.012 54.0 noncon
hsa-miR-3152-5p 2903-2910 -0.323 96.0 -0.001 32.0 noncon
hsa-miR-124-3p.1 2068-2075 -0.32 96.0 -0.001 46.0 con
hsa-miR-125a-3p 1360-1367 -0.31 97.0 -0.012 46.0 noncon
hsa-miR-624-5p 3343-3350 -0.309 94.0 -0.001 15.0 noncon
hsa-miR-4261 1576-1583 -0.309 97.0 -0.012 41.0 noncon
hsa-miR-616-3p 628-635 -0.306 97.0 -0.278 97.0 noncon
hsa-miR-491-5p 3148-3155 -0.306 95.0 -0.001 13.0 noncon
hsa-miR-5589-3p 887-894 -0.306 97.0 -0.275 97.0 noncon
hsa-miR-4638-3p 3383-3390 -0.304 95.0 -0.001 21.0 noncon
hsa-miR-5187-3p 466-473 -0.302 98.0 -0.275 98.0 noncon
hsa-miR-6515-3p 379-386 -0.3 98.0 -0.3 98.0 noncon
hsa-miR-4654 3185-3192 -0.299 96.0 -0.001 19.0 noncon
hsa-miR-4776-3p 3570-3577 -0.299 96.0 -0.001 30.0 noncon
hsa-miR-409-5p 1395-1401 -0.295 93.0 -0.012 35.0 noncon
hsa-miR-1205 1046-1053 -0.292 98.0 -0.247 97.0 noncon
hsa-miR-4728-3p 49-56 -0.292 97.0 -0.292 98.0 noncon
hsa-miR-6732-3p 519-525 -0.286 97.0 -0.26 97.0 noncon
hsa-miR-6511b-5p 1045-1051 -0.286 95.0 -0.242 95.0 noncon
hsa-miR-7153-3p 263-269 -0.283 97.0 -0.283 98.0 noncon
hsa-miR-6832-3p 3449-3456 -0.281 97.0 -0.001 32.0 noncon
hsa-miR-4778-3p 3264-3271 -0.281 96.0 -0.001 40.0 noncon
hsa-miR-4302 220-227 -0.281 97.0 -0.281 98.0 noncon
hsa-miR-6871-3p 685-691 -0.28 95.0 -0.255 96.0 noncon
hsa-miR-6811-5p 1045-1051 -0.279 95.0 -0.236 95.0 noncon
hsa-miR-889-5p 127-133 -0.278 95.0 -0.278 97.0 noncon
hsa-miR-4291 358-365 -0.278 96.0 -0.278 97.0 noncon
hsa-miR-519d-5p 1074-1081 -0.276 97.0 -0.234 97.0 noncon
hsa-miR-675-3p 52-58 -0.274 95.0 -0.274 97.0 noncon
hsa-miR-548an 2002-2009 -0.272 97.0 -0.011 40.0 noncon
hsa-miR-586 1146-1153 -0.268 96.0 -0.227 96.0 noncon
hsa-miR-130b-5p 241-247 -0.268 97.0 -0.268 98.0 noncon
hsa-miR-4699-5p 1006-1013 -0.266 96.0 -0.24 97.0 noncon
hsa-miR-30e-3p 1212-1219 -0.262 98.0 -0.222 97.0 noncon
hsa-miR-1229-5p 3295-3302 -0.262 95.0 -0.001 33.0 noncon
hsa-miR-6856-3p 767-773 -0.26 94.0 -0.235 94.0 noncon
hsa-miR-19b-2-5p 3573-3580 -0.258 97.0 -0.001 42.0 noncon
hsa-miR-218-1-3p 459-465 -0.258 92.0 -0.255 94.0 noncon
hsa-miR-627-3p 2171-2178 -0.256 97.0 -0.001 33.0 noncon
hsa-miR-5586-3p 2145-2152 -0.256 96.0 -0.001 25.0 noncon
hsa-miR-4650-5p 1043-1049 -0.256 96.0 -0.217 96.0 noncon
hsa-miR-30d-3p 1212-1219 -0.254 97.0 -0.215 97.0 noncon
hsa-miR-30a-3p 1212-1219 -0.254 97.0 -0.215 97.0 noncon
hsa-miR-605-3p 793-799 -0.251 92.0 -0.227 92.0 noncon
hsa-miR-455-3p.2 3123-3129 -0.25 97.0 -0.001 52.0 noncon