GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 

Glycogene class
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
B3GALNT2
B3GALT2
B3GAT1
B3GAT2
B3GNT2
B3GNT4
B3GNT7
B3GNT8
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
CHST1
CHST10
CHST2
CHST3
CHST4
CHST5
CHST8
CHST9
CMAS
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
EDEM1
EDEM2
EDEM3
ENGASE
FPGT
FUCA1
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
GAL3ST2
GAL3ST3
GANAB
GCNT2
GNPNAT1
GNPTAB
GNPTG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MOGS
NAGK
NAGPA
NEU1
NEU2
NEU3
NEU4
PRKCSH
RPN1
RPN2
ST3GAL3
ST3GAL4
ST3GAL6
ST6GAL1
ST6GAL2
ST8SIA2
ST8SIA3
ST8SIA4
STT3A
STT3B
UGGT1
UGGT2
Pathway Map

ALG5



General Information
Gene Symbol:   
ALG5
Protein name:   
Dolichyl-phosphate beta-glucosyltransferase
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT2
E.C. No:   
Organs:   
Reaction (SNFG):   
+ Dol-P
+ UDP
Reaction (IUBMB):   
No specified reaction.

About

• Involved in the synthesis of Dol-P-Glc, using UDP-Glc as donor


Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
Reactome:   

Related Database
Organism:   
Homo sapiens
Uniprot:   
NCBI GeneID:   
GlyMap GeneID:   
DNA aRefSeq:   
Protein RefSeq:   
BRENDA:   
OMIM number:   
GeneCards database:   

Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     Dol-P
Product:  
     Glc(a1-?)Dol-P

Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN











Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data

miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6888-3p 265-272 -0.624 99.0 -0.001 35.0 noncon
hsa-miR-3618 262-269 -0.601 99.0 -0.001 12.0 noncon
hsa-miR-146a-3p 343-350 -0.594 99.0 -0.001 27.0 noncon
hsa-miR-203a-3p.1 42-49 -0.529 99.0 -0.529 99.0 noncon
hsa-miR-508-3p 325-332 -0.529 99.0 -0.001 18.0 noncon
hsa-miR-3688-3p 133-140 -0.509 99.0 -0.012 46.0 noncon
hsa-miR-205-3p 80-87 -0.462 99.0 -0.451 99.0 noncon
hsa-miR-4501 39-45 -0.449 99.0 -0.449 99.0 noncon
hsa-miR-6511b-5p 292-298 -0.443 98.0 -0.001 36.0 noncon
hsa-miR-6811-5p 292-298 -0.436 98.0 -0.001 34.0 noncon
hsa-miR-555 279-285 -0.404 97.0 -0.001 16.0 noncon
hsa-miR-1283 260-267 -0.402 99.0 -0.001 19.0 noncon
hsa-miR-6715b-5p 290-296 -0.399 99.0 -0.001 46.0 noncon
hsa-miR-6083 165-172 -0.391 99.0 -0.007 65.0 noncon
hsa-miR-127-5p 224-230 -0.376 98.0 -0.004 38.0 noncon
hsa-miR-3166 101-107 -0.372 96.0 -0.01 29.0 noncon
hsa-miR-4729 168-175 -0.364 99.0 -0.006 55.0 noncon
hsa-miR-1206 306-312 -0.359 98.0 -0.001 23.0 noncon
hsa-miR-6511a-5p 103-109 -0.341 99.0 -0.009 48.0 noncon
hsa-miR-1910-3p 103-109 -0.337 99.0 -0.009 57.0 noncon
hsa-miR-3117-5p 36-42 -0.331 98.0 -0.331 98.0 noncon
hsa-miR-542-3p 38-44 -0.326 98.0 -0.326 98.0 noncon
hsa-miR-4269 290-296 -0.325 99.0 -0.001 56.0 noncon
hsa-miR-4504 38-44 -0.323 98.0 -0.323 98.0 noncon
hsa-miR-4282 65-72 -0.314 99.0 -0.314 99.0 noncon
hsa-miR-3714 104-110 -0.312 99.0 -0.009 56.0 noncon
hsa-miR-548c-3p 174-181 -0.308 99.0 -0.005 72.0 noncon
hsa-miR-3978 132-138 -0.305 99.0 -0.007 64.0 noncon
hsa-miR-5688 216-222 -0.304 99.0 -0.003 69.0 noncon
hsa-miR-4712-3p 302-308 -0.296 98.0 -0.001 31.0 noncon
hsa-miR-8066 40-46 -0.29 98.0 -0.29 98.0 noncon
hsa-miR-607 54-61 -0.29 99.0 -0.29 99.0 noncon
hsa-miR-4743-3p 266-272 -0.285 98.0 -0.001 44.0 noncon
hsa-miR-216b-5p 346-352 -0.277 97.0 -0.001 31.0 noncon
hsa-miR-548an 105-111 -0.277 97.0 -0.008 36.0 noncon
hsa-miR-4693-3p 301-307 -0.276 93.0 -0.001 18.0 noncon
hsa-miR-6841-5p 281-287 -0.271 91.0 -0.001 17.0 noncon
hsa-miR-495-3p 216-222 -0.261 99.0 -0.003 70.0 noncon
hsa-miR-3144-3p 368-374 -0.26 93.0 -0.001 18.0 noncon
hsa-miR-4703-3p 322-328 -0.254 94.0 -0.001 20.0 noncon