GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT3



General Information
Gene Symbol:   
GALNT3
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 3
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• ppGalNAc-T1 is localized throughout the Golgi
• Mutations in ppGalNAcT activity can result in various diseases.
• ppGalNAc-T2 and ppGalNAc-T3 were more abundant in the trans and medial Golgi.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-190372
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q14435 
NCBI GeneID:   
2591
GlyMap GeneID:   
2591
DNA aRefSeq:   
NM_004482.3 
Protein RefSeq:   
NP_004473.2 
BRENDA:   
Kinetic info.
OMIM number:   
601756
GeneCards database:   
GALNT3
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3679-3p 1034-1041 -0.572 99.0 -0.182 90.0 noncon
hsa-miR-5706 471-478 -0.532 99.0 -0.532 99.0 noncon
hsa-miR-4782-5p 471-478 -0.524 99.0 -0.524 99.0 noncon
hsa-miR-425-3p 1293-1300 -0.514 98.0 -0.107 72.0 noncon
hsa-miR-218-5p 181-188 -0.486 99.0 -0.486 99.0 con
hsa-miR-1178-5p 1375-1382 -0.485 99.0 -0.101 78.0 noncon
hsa-miR-9-5p 200-207 -0.48 99.0 -0.48 99.0 con
hsa-miR-4267 1436-1443 -0.46 99.0 -0.037 75.0 noncon
hsa-miR-574-5p 330-337 -0.446 98.0 -0.446 98.0 noncon
hsa-miR-222-3p 141-148 -0.436 98.0 -0.436 98.0 noncon
hsa-miR-7852-3p 405-412 -0.419 99.0 -0.419 99.0 noncon
hsa-miR-4638-3p 219-226 -0.419 98.0 -0.419 98.0 noncon
hsa-miR-122-5p 629-636 -0.409 99.0 -0.409 99.0 noncon
hsa-miR-221-3p 141-148 -0.404 97.0 -0.404 98.0 noncon
hsa-miR-885-5p 879-886 -0.398 99.0 -0.398 99.0 noncon
hsa-miR-890 267-274 -0.386 99.0 -0.386 99.0 noncon
hsa-miR-6811-5p 1425-1431 -0.371 98.0 -0.08 80.0 noncon
hsa-miR-6783-5p 351-358 -0.371 98.0 -0.371 99.0 noncon
hsa-miR-6505-5p 108-115 -0.356 99.0 -0.356 99.0 noncon
hsa-miR-802 858-865 -0.356 98.0 -0.356 99.0 noncon
hsa-miR-885-5p 898-905 -0.354 98.0 -0.354 99.0 noncon
hsa-miR-4477b 542-549 -0.353 98.0 -0.353 98.0 noncon
hsa-miR-421 734-741 -0.343 98.0 -0.343 98.0 noncon
hsa-miR-20a-3p 822-829 -0.342 97.0 -0.342 98.0 noncon
hsa-miR-520a-3p 642-649 -0.339 98.0 -0.339 98.0 con
hsa-miR-628-5p 430-436 -0.337 98.0 -0.337 98.0 noncon
hsa-miR-3606-5p 786-793 -0.334 97.0 -0.334 98.0 noncon
hsa-miR-520d-3p 642-649 -0.331 98.0 -0.331 98.0 con
hsa-miR-4720-3p 1181-1188 -0.33 98.0 -0.111 87.0 noncon
hsa-miR-361-5p 1168-1175 -0.326 97.0 -0.11 83.0 noncon
hsa-miR-20b-3p 151-158 -0.326 98.0 -0.326 98.0 noncon
hsa-miR-302d-3p 642-649 -0.321 98.0 -0.321 98.0 con
hsa-miR-2467-5p 1337-1344 -0.32 97.0 -0.07 85.0 noncon
hsa-miR-4683 1276-1282 -0.316 97.0 -0.069 81.0 noncon
hsa-miR-520e 642-649 -0.315 98.0 -0.315 98.0 con
hsa-miR-372-3p 642-649 -0.315 97.0 -0.315 98.0 con
hsa-miR-520c-3p 642-649 -0.315 97.0 -0.315 98.0 con
hsa-miR-520b 642-649 -0.315 97.0 -0.315 98.0 con
hsa-miR-1253 1383-1390 -0.309 98.0 -0.068 76.0 noncon
hsa-miR-302e 642-649 -0.305 98.0 -0.305 98.0 con
hsa-miR-302c-3p.1 642-649 -0.305 97.0 -0.305 98.0 con
hsa-miR-302b-3p 642-649 -0.305 97.0 -0.305 98.0 con
hsa-miR-302a-3p 642-649 -0.305 97.0 -0.305 98.0 con
hsa-miR-1185-5p 960-966 -0.302 96.0 -0.302 97.0 noncon
hsa-miR-6511b-5p 1425-1431 -0.301 96.0 -0.066 78.0 noncon
hsa-miR-8069 1085-1092 -0.297 97.0 -0.101 88.0 noncon
hsa-miR-2115-3p 1167-1174 -0.296 98.0 -0.101 86.0 noncon
hsa-miR-7-5p 651-657 -0.291 96.0 -0.291 97.0 con
hsa-miR-4477b 655-662 -0.289 96.0 -0.289 97.0 noncon
hsa-miR-655-3p 1414-1421 -0.288 97.0 -0.064 74.0 noncon
hsa-miR-1257 324-331 -0.285 96.0 -0.285 97.0 noncon
hsa-miR-374a-3p 1169-1176 -0.278 98.0 -0.095 88.0 noncon
hsa-miR-3681-3p 48-54 -0.278 97.0 -0.278 97.0 con
hsa-miR-27a-3p 48-54 -0.269 96.0 -0.269 97.0 con
hsa-miR-27b-3p 48-54 -0.269 96.0 -0.269 97.0 con
hsa-miR-802 388-394 -0.266 96.0 -0.266 97.0 noncon
hsa-miR-374c-5p 1414-1421 -0.264 96.0 -0.058 73.0 noncon
hsa-miR-3923 191-197 -0.254 92.0 -0.254 95.0 noncon
hsa-miR-1236-3p 233-240 -0.253 94.0 -0.253 95.0 noncon
hsa-miR-216a-3p 48-54 -0.253 96.0 -0.253 97.0 con
hsa-miR-499b-3p 277-283 -0.252 97.0 -0.252 98.0 noncon
hsa-miR-153-3p 83-89 -0.252 93.0 -0.252 95.0 con
hsa-miR-1305 18-25 -0.252 99.0 -0.252 99.0 noncon
hsa-miR-374c-5p 1158-1165 -0.251 95.0 -0.086 81.0 noncon