GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
B3GALNT2
B3GALT2
B3GAT1
B3GAT2
B3GNT2
B3GNT4
B3GNT7
B3GNT8
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
CHST1
CHST10
CHST2
CHST3
CHST4
CHST5
CHST8
CHST9
CMAS
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
EDEM1
EDEM2
EDEM3
ENGASE
FPGT
FUCA1
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
GAL3ST2
GAL3ST3
GANAB
GCNT2
GNPNAT1
GNPTAB
GNPTG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MOGS
NAGK
NAGPA
NEU1
NEU2
NEU3
NEU4
PRKCSH
RPN1
RPN2
ST3GAL3
ST3GAL4
ST3GAL6
ST6GAL1
ST6GAL2
ST8SIA2
ST8SIA3
ST8SIA4
STT3A
STT3B
UGGT1
UGGT2
Pathway Map
ALG13



General Information
Gene Symbol:   
ALG13
Protein name:   
Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.141
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Alg13/Alg14 are part of a heterodimer that transfers second GlcNAc from UDP-GlcNAc to generate Dol-PP-GlcNAc2
• Cells lacking these activities grow slowly, and mutations in Alg13 leads to CDG-1r

Related Pathway
KEGG ORTHOLOGY:   
K07432
KEGG Pathway:   
ko00510  ko00513  ko01100 
Reactome:   
R-HSA-446193
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9NP73 
NCBI GeneID:   
79868
GlyMap GeneID:   
79868
DNA aRefSeq:   
NM_001039210.4 
Protein RefSeq:   
NP_001034299.3 
BRENDA:   
Kinetic info.
OMIM number:   
300776
GeneCards database:   
ALG13
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     GlcNAc(a1-?)Dol-PP
Product:  
     GlcNAc(b1-4)GlcNAc(a1-?)Dol-PP
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6803-5p 29-36 -0.848 99.0 -0.806 99.0 noncon
hsa-miR-6751-5p 29-36 -0.827 99.0 -0.787 99.0 noncon
hsa-miR-3622a-5p 602-609 -0.785 99.0 -0.721 99.0 noncon
hsa-miR-4711-5p 778-785 -0.72 99.0 -0.661 99.0 noncon
hsa-miR-8065 111-118 -0.681 99.0 -0.637 99.0 noncon
hsa-miR-218-1-3p 420-427 -0.657 99.0 -0.606 99.0 noncon
hsa-miR-4423-3p 603-610 -0.629 99.0 -0.581 99.0 noncon
hsa-miR-3924 71-78 -0.609 99.0 -0.581 99.0 noncon
hsa-miR-409-5p 2161-2168 -0.575 99.0 0.0 0.0 noncon
hsa-miR-876-3p 2084-2091 -0.553 99.0 -0.002 25.0 noncon
hsa-miR-6853-3p 765-772 -0.55 99.0 -0.509 99.0 noncon
hsa-miR-711 162-169 -0.532 99.0 -0.493 99.0 noncon
hsa-miR-6758-3p 282-289 -0.517 99.0 -0.479 99.0 noncon
hsa-miR-567 579-586 -0.503 99.0 -0.466 99.0 noncon
hsa-miR-297 580-587 -0.502 99.0 -0.465 99.0 noncon
hsa-miR-6891-3p 2100-2107 -0.5 99.0 -0.002 42.0 noncon
hsa-miR-6789-5p 1453-1460 -0.488 98.0 -0.002 28.0 noncon
hsa-miR-99a-5p 2382-2388 -0.486 96.0 0.0 0.0 noncon
hsa-miR-6085 1452-1459 -0.479 99.0 -0.002 18.0 noncon
hsa-miR-6072 2100-2107 -0.479 99.0 -0.002 39.0 noncon
hsa-miR-100-5p 2382-2388 -0.475 96.0 0.0 0.0 noncon
hsa-miR-3200-3p 1849-1856 -0.472 99.0 -0.002 43.0 noncon
hsa-miR-6503-3p 1661-1668 -0.472 99.0 -0.002 42.0 noncon
hsa-miR-6813-5p 1452-1459 -0.466 99.0 -0.002 22.0 noncon
hsa-miR-4425 996-1003 -0.462 98.0 -0.002 14.0 noncon
hsa-miR-99b-5p 2382-2388 -0.46 96.0 0.0 0.0 noncon
hsa-miR-8089 1478-1485 -0.46 99.0 -0.002 24.0 noncon
hsa-miR-628-3p 194-201 -0.459 99.0 -0.426 99.0 noncon
hsa-miR-6835-5p 29-35 -0.456 98.0 -0.437 98.0 noncon
hsa-miR-659-3p 421-428 -0.454 99.0 -0.421 99.0 noncon
hsa-miR-6780b-5p 1476-1483 -0.444 98.0 -0.002 24.0 noncon
hsa-miR-4667-5p 1478-1485 -0.441 99.0 -0.002 20.0 noncon
hsa-miR-656-3p 93-100 -0.44 99.0 -0.414 99.0 noncon
hsa-miR-4521 334-341 -0.433 99.0 -0.402 99.0 noncon
hsa-miR-4699-5p 211-218 -0.432 99.0 -0.401 99.0 noncon
hsa-miR-6777-3p 544-551 -0.43 98.0 -0.399 98.0 noncon
hsa-miR-4725-3p 1476-1483 -0.428 98.0 -0.002 24.0 noncon
hsa-miR-6888-3p 2033-2040 -0.428 98.0 -0.002 38.0 noncon
hsa-miR-548av-3p 180-187 -0.428 99.0 -0.397 99.0 noncon
hsa-miR-892c-3p 353-360 -0.427 99.0 -0.396 99.0 noncon
hsa-miR-582-5p 716-723 -0.425 99.0 -0.395 99.0 noncon
hsa-miR-4700-5p 1478-1485 -0.423 99.0 -0.002 21.0 noncon
hsa-miR-1295b-5p 1991-1998 -0.423 99.0 -0.002 28.0 noncon
hsa-miR-4676-3p 353-360 -0.419 99.0 -0.389 99.0 noncon
hsa-miR-26b-3p 539-546 -0.413 98.0 -0.384 98.0 noncon
hsa-miR-452-5p 353-360 -0.408 99.0 -0.379 99.0 noncon
hsa-miR-3680-5p 1196-1203 -0.405 99.0 -0.002 35.0 noncon
hsa-miR-337-3p 130-137 -0.4 99.0 -0.372 99.0 noncon
hsa-miR-656-3p 75-82 -0.396 99.0 -0.379 99.0 noncon
hsa-miR-4308 1279-1286 -0.394 99.0 -0.002 27.0 noncon
hsa-miR-4762-5p 287-294 -0.391 99.0 -0.363 99.0 noncon
hsa-miR-1912 1991-1998 -0.386 99.0 -0.002 24.0 noncon
hsa-miR-4495 382-389 -0.384 99.0 -0.357 99.0 noncon
hsa-miR-4665-5p 30-36 -0.382 96.0 -0.366 97.0 noncon
hsa-miR-3149 581-588 -0.381 99.0 -0.354 99.0 noncon
hsa-miR-4759 2143-2149 -0.38 99.0 -0.002 20.0 noncon
hsa-miR-6715a-3p 625-632 -0.36 98.0 -0.335 99.0 noncon
hsa-miR-4271 1476-1483 -0.36 98.0 -0.002 32.0 noncon
hsa-miR-1275 30-36 -0.355 97.0 -0.34 98.0 noncon
hsa-miR-4456 2086-2092 -0.352 97.0 -0.002 33.0 noncon
hsa-miR-4660 2219-2226 -0.352 97.0 0.0 0.0 noncon
hsa-miR-7109-5p 30-36 -0.35 95.0 -0.336 96.0 noncon
hsa-miR-7160-3p 1307-1313 -0.34 97.0 -0.002 30.0 noncon
hsa-miR-345-3p 2296-2303 -0.34 99.0 0.0 0.0 noncon
hsa-miR-450a-2-3p 31-37 -0.338 96.0 -0.324 96.0 noncon
hsa-miR-1178-3p 226-232 -0.338 97.0 -0.315 98.0 noncon
hsa-miR-1973 1641-1647 -0.336 92.0 -0.002 11.0 noncon
hsa-miR-4652-3p 722-729 -0.336 99.0 -0.313 99.0 noncon
hsa-miR-4683 686-692 -0.335 97.0 -0.312 98.0 noncon
hsa-miR-4637 320-326 -0.335 97.0 -0.312 98.0 noncon
hsa-miR-3132 1765-1771 -0.334 93.0 -0.002 12.0 noncon
hsa-miR-6743-5p 1723-1730 -0.333 97.0 -0.002 14.0 noncon
hsa-miR-4436b-5p 258-265 -0.333 98.0 -0.31 98.0 noncon
hsa-miR-410-5p 1929-1935 -0.327 95.0 -0.002 23.0 noncon
hsa-miR-323b-5p 1929-1935 -0.327 95.0 -0.002 23.0 noncon
hsa-miR-1915-5p 1411-1417 -0.324 94.0 -0.002 30.0 noncon
hsa-miR-197-5p 1765-1771 -0.32 91.0 -0.001 12.0 noncon
hsa-miR-548aa 804-811 -0.317 99.0 -0.002 37.0 noncon
hsa-miR-548t-3p 804-811 -0.317 99.0 -0.002 37.0 noncon
hsa-miR-548ap-3p 804-811 -0.317 99.0 -0.002 37.0 noncon
hsa-miR-3607-3p 2094-2101 -0.316 99.0 -0.001 46.0 noncon
hsa-miR-4688 1723-1730 -0.315 95.0 -0.001 13.0 noncon
hsa-miR-3618 2042-2048 -0.312 92.0 -0.001 13.0 noncon
hsa-miR-3130-5p 1907-1913 -0.306 98.0 -0.001 32.0 noncon
hsa-miR-5009-3p 1977-1984 -0.306 98.0 -0.001 36.0 noncon
hsa-miR-548av-3p 2256-2263 -0.306 99.0 0.0 0.0 noncon
hsa-miR-562 523-529 -0.305 98.0 -0.284 98.0 noncon
hsa-miR-494-5p 1929-1935 -0.305 93.0 -0.001 24.0 noncon
hsa-miR-7113-3p 1281-1288 -0.304 97.0 -0.001 36.0 noncon
hsa-miR-670-3p 2102-2109 -0.304 97.0 -0.001 28.0 noncon
hsa-miR-130b-5p 2313-2320 -0.302 98.0 0.0 0.0 noncon
hsa-miR-185-3p 1451-1457 -0.299 90.0 -0.001 16.0 noncon
hsa-miR-122-3p 1921-1927 -0.298 93.0 -0.001 14.0 noncon
hsa-miR-4677-3p 694-700 -0.298 97.0 -0.278 98.0 noncon
hsa-miR-371a-5p 627-634 -0.298 99.0 -0.278 99.0 noncon
hsa-miR-4427 1678-1685 -0.297 98.0 -0.001 30.0 noncon
hsa-miR-4428 333-339 -0.296 98.0 -0.276 98.0 noncon
hsa-miR-548ah-5p 16-22 -0.296 99.0 -0.29 99.0 noncon
hsa-miR-3606-5p 958-964 -0.295 95.0 -0.001 20.0 noncon
hsa-miR-1257 231-238 -0.294 97.0 -0.274 97.0 noncon
hsa-miR-6722-3p 1754-1760 -0.293 94.0 -0.001 26.0 noncon
hsa-miR-7151-5p 439-445 -0.292 98.0 -0.272 98.0 noncon
hsa-miR-595 1899-1906 -0.289 99.0 -0.001 48.0 noncon
hsa-miR-4470 1812-1818 -0.288 97.0 -0.001 40.0 noncon
hsa-miR-545-3p 1175-1182 -0.287 98.0 -0.001 29.0 noncon
hsa-miR-154-5p 1493-1500 -0.287 97.0 -0.001 29.0 noncon
hsa-miR-4482-5p 1907-1913 -0.285 97.0 -0.001 32.0 noncon
hsa-miR-4503 1696-1703 -0.285 95.0 -0.001 22.0 noncon
hsa-miR-1295b-5p 1139-1146 -0.284 98.0 -0.001 27.0 noncon
hsa-miR-3200-3p 1412-1418 -0.282 96.0 -0.001 41.0 noncon
hsa-miR-34c-3p 588-594 -0.282 98.0 -0.263 98.0 noncon
hsa-miR-376c-3p 44-50 -0.28 96.0 -0.269 96.0 noncon
hsa-miR-4637 495-501 -0.28 96.0 -0.261 97.0 noncon
hsa-miR-3609 16-22 -0.28 98.0 -0.275 99.0 noncon
hsa-miR-659-5p 1264-1270 -0.278 94.0 -0.001 17.0 noncon
hsa-miR-550b-3p 2243-2249 -0.275 96.0 0.0 0.0 noncon
hsa-miR-6869-5p 1419-1426 -0.275 98.0 -0.001 46.0 noncon
hsa-miR-3685 1889-1895 -0.274 97.0 -0.001 46.0 noncon
hsa-miR-4784 688-694 -0.273 96.0 -0.254 96.0 noncon
hsa-miR-3150b-3p 688-694 -0.273 96.0 -0.254 96.0 noncon
hsa-miR-1912 1139-1146 -0.271 97.0 -0.001 23.0 noncon
hsa-miR-208b-5p 519-526 -0.27 97.0 -0.252 98.0 noncon
hsa-miR-6755-5p 1766-1772 -0.27 90.0 -0.001 19.0 noncon
hsa-miR-4727-5p 1714-1721 -0.269 95.0 -0.001 23.0 noncon
hsa-miR-150-5p 2057-2064 -0.268 98.0 -0.001 37.0 noncon
hsa-miR-5092 552-558 -0.263 97.0 -0.245 97.0 noncon
hsa-miR-4796-3p 16-22 -0.261 98.0 -0.256 99.0 noncon
hsa-miR-1226-5p 1309-1315 -0.258 95.0 -0.001 38.0 noncon
hsa-miR-181a-5p 125-131 -0.257 95.0 -0.242 96.0 noncon
hsa-miR-181b-5p 125-131 -0.257 95.0 -0.242 96.0 noncon
hsa-miR-1909-3p 1754-1760 -0.257 91.0 -0.001 28.0 noncon
hsa-miR-181d-5p 125-131 -0.257 95.0 -0.242 96.0 noncon
hsa-miR-5003-5p 144-150 -0.257 95.0 -0.24 95.0 noncon
hsa-miR-3129-3p 753-759 -0.256 98.0 -0.239 99.0 noncon
hsa-miR-4529-3p 1663-1669 -0.254 91.0 -0.001 19.0 noncon
hsa-miR-4693-5p 355-361 -0.252 94.0 -0.235 95.0 noncon
hsa-miR-4436b-5p 2247-2254 -0.252 97.0 0.0 0.0 noncon
hsa-miR-5582-5p 603-609 -0.251 94.0 -0.234 95.0 noncon
hsa-miR-576-3p 116-122 -0.251 96.0 -0.236 96.0 noncon
hsa-miR-6856-5p 971-977 -0.251 96.0 -0.001 37.0 noncon
hsa-miR-23c 50-56 -0.25 93.0 -0.24 94.0 noncon
hsa-miR-23b-3p 50-56 -0.25 93.0 -0.24 94.0 noncon
hsa-miR-23a-3p 50-56 -0.25 93.0 -0.24 94.0 noncon
hsa-miR-582-3p 2088-2094 -0.25 95.0 -0.001 29.0 noncon
hsa-miR-6758-5p 971-977 -0.25 96.0 -0.001 37.0 noncon