GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT11



General Information
Gene Symbol:   
GALNT11
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 11
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Involved in transfer of GalNAc to Ser/Thr on proteins to initiate O-GalNAc modification.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NCW6 
NCBI GeneID:   
63917
GlyMap GeneID:   
63917
DNA aRefSeq:   
NM_022087.3 
Protein RefSeq:   
NP_071370.2 
BRENDA:   
Kinetic info.
OMIM number:   
615130
GeneCards database:   
GALNT11
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3668 636-643 -0.546 99.0 -0.546 99.0 noncon
hsa-miR-6742-3p 350-357 -0.51 99.0 -0.51 99.0 noncon
hsa-miR-6783-3p 351-358 -0.497 99.0 -0.497 99.0 noncon
hsa-miR-1343-3p 351-358 -0.478 99.0 -0.478 99.0 noncon
hsa-miR-376a-2-5p 634-641 -0.434 99.0 -0.434 99.0 noncon
hsa-miR-4318 302-309 -0.431 99.0 -0.431 99.0 noncon
hsa-miR-519c-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-519b-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-520c-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-518f-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-518e-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-519a-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-518d-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-523-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-526a 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-522-5p 319-326 -0.41 99.0 -0.41 99.0 noncon
hsa-miR-1273g-3p 414-420 -0.402 99.0 -0.402 99.0 noncon
hsa-miR-383-5p.1 427-434 -0.401 97.0 -0.401 98.0 noncon
hsa-miR-5009-3p 663-670 -0.399 99.0 -0.002 39.0 noncon
hsa-miR-3152-5p 294-301 -0.391 98.0 -0.391 98.0 noncon
hsa-miR-4450 398-404 -0.374 96.0 -0.374 98.0 noncon
hsa-miR-1237-3p 338-345 -0.365 99.0 -0.365 99.0 noncon
hsa-miR-6835-3p 477-484 -0.356 99.0 -0.356 99.0 noncon
hsa-miR-4328 540-547 -0.336 99.0 -0.336 99.0 noncon
hsa-miR-6078 31-37 -0.332 96.0 -0.332 97.0 noncon
hsa-miR-6817-5p 593-599 -0.33 98.0 -0.33 98.0 noncon
hsa-miR-3680-5p 227-234 -0.326 98.0 -0.326 99.0 noncon
hsa-miR-4670-3p 562-569 -0.323 98.0 -0.323 99.0 noncon
hsa-miR-4769-3p 593-599 -0.319 98.0 -0.319 98.0 noncon
hsa-miR-412-3p 197-204 -0.304 97.0 -0.304 97.0 noncon
hsa-miR-6828-3p 86-93 -0.302 96.0 -0.302 97.0 noncon
hsa-miR-5590-5p 592-598 -0.295 97.0 -0.295 98.0 noncon
hsa-miR-4660 264-270 -0.294 95.0 -0.294 96.0 noncon
hsa-miR-4320 648-654 -0.293 96.0 -0.293 97.0 noncon
hsa-miR-5695 98-105 -0.289 98.0 -0.289 98.0 noncon
hsa-miR-508-3p 631-637 -0.288 96.0 -0.288 97.0 noncon
hsa-miR-152-5p 89-96 -0.281 94.0 -0.281 95.0 noncon
hsa-miR-412-3p 219-226 -0.279 96.0 -0.279 97.0 noncon
hsa-miR-4760-3p 620-627 -0.27 99.0 -0.27 99.0 noncon
hsa-miR-4798-3p 228-234 -0.263 97.0 -0.263 98.0 noncon
hsa-miR-1322 574-580 -0.261 97.0 -0.261 98.0 noncon
hsa-miR-6754-3p 197-204 -0.254 95.0 -0.254 96.0 noncon
hsa-miR-1237-3p 568-574 -0.252 97.0 -0.252 97.0 noncon
hsa-miR-3935 635-641 -0.252 92.0 -0.252 95.0 noncon