GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT9



General Information
Gene Symbol:   
GALNT9
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 9
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Localized in Golgi where it catalyzes O-GalNAc glycosylation.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9HCQ5 
NCBI GeneID:   
50614
GlyMap GeneID:   
50614
DNA aRefSeq:   
NM_001122636.1 
Protein RefSeq:   
NP_001116108.1 
BRENDA:   
Kinetic info.
OMIM number:   
606251
GeneCards database:   
GALNT9
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6885-5p 320-327 -0.571 96.0 -0.571 97.0 noncon
hsa-miR-6882-3p 592-599 -0.553 99.0 -0.553 99.0 noncon
hsa-miR-4642 238-245 -0.553 99.0 -0.553 99.0 noncon
hsa-miR-6784-5p 347-354 -0.552 98.0 -0.552 98.0 noncon
hsa-miR-4723-3p 582-589 -0.522 99.0 -0.522 99.0 noncon
hsa-miR-328-5p 320-327 -0.493 96.0 -0.493 97.0 noncon
hsa-miR-6769b-3p 582-589 -0.49 99.0 -0.49 99.0 noncon
hsa-miR-3656 385-392 -0.481 97.0 -0.481 98.0 noncon
hsa-miR-6843-3p 570-577 -0.474 99.0 -0.474 99.0 noncon
hsa-miR-6075 42-49 -0.469 97.0 -0.469 98.0 noncon
hsa-miR-6893-3p 89-96 -0.466 99.0 -0.466 99.0 noncon
hsa-miR-6820-5p 675-682 -0.462 94.0 -0.462 95.0 noncon
hsa-miR-4505 726-733 -0.449 99.0 -0.001 23.0 noncon
hsa-miR-3183 582-589 -0.449 99.0 -0.449 99.0 noncon
hsa-miR-1908-3p 429-435 -0.443 94.0 -0.443 95.0 noncon
hsa-miR-6829-5p 680-687 -0.437 98.0 -0.437 99.0 noncon
hsa-miR-6746-3p 202-208 -0.395 94.0 -0.395 95.0 noncon
hsa-miR-571 242-249 -0.389 98.0 -0.389 98.0 noncon
hsa-miR-6848-3p 570-577 -0.388 99.0 -0.388 99.0 noncon
hsa-miR-5787 726-733 -0.387 99.0 -0.001 34.0 noncon
hsa-miR-3194-5p 548-555 -0.386 98.0 -0.386 98.0 noncon
hsa-miR-3675-5p 329-336 -0.384 97.0 -0.384 98.0 noncon
hsa-miR-661 659-666 -0.381 98.0 -0.381 99.0 noncon
hsa-miR-370-3p 89-96 -0.377 99.0 -0.377 99.0 noncon
hsa-miR-1199-3p 430-436 -0.377 96.0 -0.377 96.0 noncon
hsa-miR-6515-5p 441-448 -0.372 97.0 -0.372 98.0 noncon
hsa-miR-548a-3p 712-719 -0.369 99.0 -0.369 99.0 noncon
hsa-miR-4447 18-25 -0.367 98.0 -0.367 98.0 noncon
hsa-miR-4472 18-25 -0.367 98.0 -0.367 98.0 noncon
hsa-miR-3164 458-465 -0.365 98.0 -0.365 98.0 noncon
hsa-miR-6820-3p 458-465 -0.365 98.0 -0.365 98.0 noncon
hsa-miR-548ar-3p 712-719 -0.364 99.0 -0.364 99.0 noncon
hsa-miR-548f-3p 712-719 -0.35 99.0 -0.35 99.0 noncon
hsa-miR-124-3p.1 255-261 -0.345 97.0 -0.345 98.0 con
hsa-miR-548e-3p 712-719 -0.342 99.0 -0.342 99.0 noncon
hsa-miR-4467 298-304 -0.337 92.0 -0.337 93.0 noncon
hsa-miR-548az-3p 712-719 -0.334 99.0 -0.334 99.0 noncon
hsa-miR-6870-5p 415-422 -0.333 90.0 -0.333 92.0 noncon
hsa-miR-4723-5p 415-422 -0.333 90.0 -0.333 92.0 noncon
hsa-miR-5698 415-422 -0.333 90.0 -0.333 92.0 noncon
hsa-miR-4691-3p 56-63 -0.328 98.0 -0.328 98.0 noncon
hsa-miR-93-3p 564-571 -0.324 98.0 -0.324 98.0 noncon
hsa-miR-3622a-5p 254-260 -0.317 98.0 -0.317 99.0 noncon
hsa-miR-508-5p 177-184 -0.316 98.0 -0.316 99.0 noncon
hsa-miR-558 475-481 -0.314 97.0 -0.314 97.0 noncon
hsa-miR-134-3p 20-27 -0.312 97.0 -0.312 97.0 noncon
hsa-miR-6748-3p 94-100 -0.312 95.0 -0.312 96.0 noncon
hsa-miR-7111-3p 583-589 -0.311 97.0 -0.311 97.0 noncon
hsa-miR-6728-3p 566-573 -0.305 97.0 -0.305 98.0 noncon
hsa-miR-4731-5p 418-425 -0.301 97.0 -0.301 97.0 noncon
hsa-miR-346 81-88 -0.297 92.0 -0.297 94.0 noncon
hsa-miR-3178 723-729 -0.295 92.0 -0.001 11.0 noncon
hsa-miR-5002-5p 573-580 -0.292 98.0 -0.292 98.0 noncon
hsa-miR-1233-3p 98-104 -0.291 96.0 -0.291 97.0 noncon
hsa-miR-2467-3p 303-310 -0.286 96.0 -0.286 97.0 noncon
hsa-miR-4715-5p 241-247 -0.279 94.0 -0.279 96.0 noncon
hsa-miR-3139 477-483 -0.277 96.0 -0.277 97.0 noncon
hsa-miR-4742-3p 708-714 -0.276 96.0 -0.276 97.0 noncon
hsa-miR-6085 687-693 -0.268 94.0 -0.268 95.0 noncon
hsa-miR-6813-5p 687-693 -0.264 94.0 -0.264 95.0 noncon
hsa-miR-4485-5p 200-206 -0.263 91.0 -0.263 94.0 noncon
hsa-miR-6779-3p 97-103 -0.259 96.0 -0.259 97.0 noncon
hsa-miR-6840-3p 615-622 -0.256 98.0 -0.256 99.0 noncon
hsa-miR-4691-3p 144-151 -0.253 95.0 -0.253 97.0 noncon