GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
A3GALT2
A4GALT
A4GNT
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
AMDHD2
B3GALNT1
B3GALNT2
B3GALT1
B3GALT2
B3GALT4
B3GALT5
B3GALT6
B3GAT1
B3GAT2
B3GAT3
B3GLCT
B3GNT2
B3GNT3
B3GNT4
B3GNT5
B3GNT6
B3GNT7
B3GNT8
B4GALNT1
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
B4GALT6
B4GALT7
C1GALT1
C1GALT1C1
CALR
CANX
CEMIP2
CHPF
CHPF2
CHST1
CHST10
CHST11
CHST12
CHST13
CHST14
CHST15
CHST2
CHST3
CHST4
CHST5
CHST6
CHST7
CHST8
CHST9
CHSY1
CHSY3
CMAS
CSGALNACT1
CSGALNACT2
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
DPY19L1
DPY19L2
DPY19L3
DPY19L4
DSE
DSEL
EDEM1
EDEM2
EDEM3
ENGASE
EOGT
EXT1
EXT2
EXTL1
EXTL2
EXTL3
FAM20B
FCSK
FKRP
FKTN
FPGT
FUCA1
FUCA2
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
G6PC1
GAL3ST1
GAL3ST2
GAL3ST3
GAL3ST4
GALC
GALE
GALK1
GALK2
GALNS
GALNT1
GALNT10
GALNT11
GALNT12
GALNT13
GALNT14
GALNT15
GALNT16
GALNT17
GALNT18
GALNT2
GALNT3
GALNT4
GALNT5
GALNT6
GALNT7
GALNT8
GALNT9
GALNTL6
GALT
GANAB
GANC
GBA
GBGT1
GCK
GCNT1
GCNT2
GCNT3
GCNT4
GCNT7
GFPT1
GFPT2
GLA
TMEM2
GLB1
GLCE
GMDS
GMPPA
GMPPB
GNE
GNPDA1
GNPDA2
GNPNAT1
GNPTAB
GNPTG
GNS
GPAA1
GPI
GUSB
GXYLT1
GXYLT2
HAS1
HAS2
HAS3
HEXA
HEXB
HK1
HK2
HK3
HPSE
HGSNAT
HS2ST1
HS3ST1
HS3ST2
HS3ST3A1
HS3ST3B1
HS3ST4
HS3ST5
HS3ST6
HS6ST1
HS6ST2
HS6ST3
HYAL1
HYAL2
HYAL3
HYAL4
IDS
IDUA
LFNG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MANEAL
MFNG
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MGAT5B
MOGS
MPI
MPPE1
NAGA
NAGK
NAGLU
NAGPA
NANS
NDST1
NDST2
NDST3
NDST4
NEU1
NEU2
NEU3
NEU4
OGT
PAPSS1
PAPSS2
PGAP4
PGM1
PGM2
PGM3
PIGA
PIGB
PIGC
PIGF
PIGG
PIGH
PIGK
PIGL
PIGM
PIGN
PIGO
PIGP
PIGQ
PIGS
PIGT
PIGU
PIGV
PIGW
PIGX
PIGY
PMM1
PMM2
POFUT1
POFUT2
POGLUT1
POGLUT2
POGLUT3
POMGNT1
POMGNT2
POMT1
POMT2
PRKCSH
RENBP
RFNG
RPN1
RPN2
RXYLT1
SGSH
SLC2A1
SLC2A10
SLC2A12
SLC2A2
SLC2A3
SLC2A4
SLC2A5
SLC2A8
SLC35A1
SLC35A2
SLC35A3
SLC35B2
SLC35B3
SLC35B4
SLC35C1
SLC35D1
SLC35D2
ST3GAL1
ST3GAL2
ST3GAL3
ST3GAL4
ST3GAL5
ST3GAL6
ST6GAL1
ST6GAL2
ST6GALNAC1
ST6GALNAC2
ST6GALNAC3
ST6GALNAC4
ST6GALNAC5
ST6GALNAC6
ST8SIA1
ST8SIA2
ST8SIA3
ST8SIA4
ST8SIA5
ST8SIA6
STT3A
STT3B
SULF1
SULF2
TMTC1
TMTC2
TMTC3
TMTC4
TSTA3
UAP1
UGCG
UGDH
UGGT1
UGGT2
UGP2
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
UGT2A2
UGT2A3
UGT2B10
UGT2B11
UGT2B15
UGT2B17
UGT2B28
UGT2B4
UGT2B7
UGT3A1
UGT3A2
UGT8
UST
UXS1
XXYLT1
XYLT1
XYLT2
AGA
ARSK
ARSB
GAA
CMAHP
Pathway Map
UAP1



General Information
Gene Symbol:   
UAP1
Protein name:   
UDP-N-acetylhexosamine pyrophosphorylase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.7.7.83
Organs:   
Reaction (SNFG):   

GlcNAc(1P) or GalNAc(1P) → UDP-GlcNAc or UDP-GalNAc
Reaction (IUBMB):   
No specified reaction.
About

• Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P
• Little is known how this enzyme plays roles in disease.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-446210
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q16222 
NCBI GeneID:   
6675
GlyMap GeneID:   
6675
DNA aRefSeq:   
NM_001324113.1 
Protein RefSeq:   
NP_001311042.1 
BRENDA:   
Kinetic info.
OMIM number:   
602862
GeneCards database:   
UAP1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(1P) or GalNAc(1P)
Product:  
     UDP-GlcNAc or UDP-GalNAc
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 600 500 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-624-5p 383-390 -0.664 99.0 -0.664 99.0 noncon
hsa-miR-4470 18-25 -0.646 99.0 -0.646 99.0 noncon
hsa-miR-6890-3p 441-448 -0.611 99.0 -0.611 99.0 noncon
hsa-miR-376b-5p 99-106 -0.534 99.0 -0.534 99.0 noncon
hsa-miR-571 196-203 -0.521 99.0 -0.521 99.0 noncon
hsa-miR-549a 1229-1236 -0.508 99.0 0.0 0.0 noncon
hsa-miR-212-5p 235-242 -0.48 99.0 -0.48 99.0 con
hsa-miR-6747-3p 283-290 -0.468 99.0 -0.468 99.0 noncon
hsa-miR-376c-5p 99-106 -0.453 99.0 -0.453 99.0 noncon
hsa-miR-27a-3p 58-65 -0.441 99.0 -0.441 99.0 con
hsa-miR-27b-3p 58-65 -0.441 99.0 -0.441 99.0 con
hsa-miR-599 406-413 -0.412 99.0 -0.412 99.0 con
hsa-miR-7154-3p 669-676 -0.402 98.0 -0.001 35.0 noncon
hsa-miR-5704 825-832 -0.395 95.0 -0.001 11.0 noncon
hsa-miR-4504 1231-1238 -0.394 99.0 0.0 0.0 noncon
hsa-miR-2115-5p 316-323 -0.393 98.0 -0.393 98.0 noncon
hsa-miR-1914-5p 792-799 -0.38 98.0 -0.001 44.0 noncon
hsa-miR-4713-5p 523-530 -0.379 98.0 -0.001 19.0 noncon
hsa-miR-6736-5p 651-658 -0.363 98.0 -0.001 24.0 noncon
hsa-miR-548as-3p 107-114 -0.36 99.0 -0.36 99.0 noncon
hsa-miR-1262 651-658 -0.36 98.0 -0.001 22.0 noncon
hsa-miR-4777-5p 1189-1196 -0.347 98.0 -0.001 34.0 noncon
hsa-miR-511-5p 1009-1016 -0.345 99.0 -0.001 45.0 noncon
hsa-miR-491-3p 543-550 -0.345 96.0 -0.001 21.0 noncon
hsa-miR-4425 194-200 -0.339 95.0 -0.339 96.0 noncon
hsa-miR-3156-3p 724-731 -0.338 97.0 -0.001 32.0 noncon
hsa-miR-4718 268-274 -0.329 95.0 -0.329 97.0 noncon
hsa-miR-4701-3p 651-658 -0.328 97.0 -0.001 22.0 noncon
hsa-miR-7705 135-141 -0.324 97.0 -0.324 98.0 noncon
hsa-miR-6776-3p 1018-1024 -0.32 97.0 -0.001 41.0 noncon
hsa-miR-1255b-2-3p 736-743 -0.317 97.0 -0.001 32.0 noncon
hsa-miR-363-5p 673-680 -0.315 96.0 -0.001 17.0 noncon
hsa-miR-181b-2-3p 596-603 -0.315 98.0 -0.001 39.0 noncon
hsa-miR-181b-3p 596-603 -0.315 98.0 -0.001 39.0 noncon
hsa-miR-3688-5p 20-26 -0.309 96.0 -0.309 97.0 noncon
hsa-miR-1265 780-787 -0.307 98.0 -0.001 36.0 noncon
hsa-miR-4264 1098-1104 -0.306 97.0 -0.001 40.0 noncon
hsa-miR-4259 195-201 -0.298 94.0 -0.298 96.0 noncon
hsa-miR-1227-3p 905-911 -0.297 94.0 -0.001 31.0 noncon
hsa-miR-758-3p 1233-1239 -0.296 97.0 0.0 0.0 noncon
hsa-miR-10a-5p 104-110 -0.296 97.0 -0.296 98.0 noncon
hsa-miR-586 541-548 -0.296 97.0 -0.001 34.0 noncon
hsa-miR-10b-5p 104-110 -0.296 97.0 -0.296 98.0 noncon
hsa-miR-6731-3p 31-37 -0.296 96.0 -0.296 97.0 noncon
hsa-miR-3148 226-233 -0.295 99.0 -0.295 99.0 noncon
hsa-miR-548ao-3p 209-215 -0.291 98.0 -0.291 98.0 noncon
hsa-miR-629-3p 524-531 -0.282 98.0 -0.001 52.0 noncon
hsa-miR-6732-3p 105-111 -0.278 96.0 -0.278 97.0 noncon
hsa-miR-6745 673-680 -0.278 94.0 -0.001 14.0 noncon
hsa-miR-150-5p 522-529 -0.276 99.0 -0.001 36.0 con
hsa-miR-1295a 826-832 -0.271 93.0 -0.001 12.0 noncon
hsa-miR-4715-3p 904-910 -0.268 97.0 -0.001 44.0 noncon
hsa-miR-3609 631-638 -0.268 98.0 -0.001 45.0 noncon
hsa-miR-6854-5p 1100-1106 -0.267 97.0 -0.001 35.0 noncon
hsa-miR-3691-5p 100-106 -0.262 91.0 -0.262 93.0 noncon
hsa-miR-589-5p 1063-1069 -0.258 95.0 -0.001 34.0 noncon
hsa-miR-548ah-5p 631-638 -0.257 98.0 -0.001 43.0 noncon
hsa-miR-7155-3p 1034-1040 -0.254 94.0 -0.001 15.0 noncon
hsa-miR-3136-3p 1034-1040 -0.254 94.0 -0.001 16.0 noncon
hsa-miR-4782-5p 157-163 -0.253 96.0 -0.253 97.0 noncon
hsa-miR-4522 577-584 -0.252 94.0 -0.001 24.0 noncon
hsa-miR-181b-3p 443-449 -0.252 96.0 -0.252 97.0 noncon
hsa-miR-181b-2-3p 443-449 -0.252 96.0 -0.252 97.0 noncon
hsa-miR-3681-3p 58-64 -0.251 96.0 -0.251 97.0 con