GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT7



General Information
Gene Symbol:   
GALNT7
Protein name:   
N-acetylgalactosaminyltransferase 7
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• In contrast to other proteins of the family, GALNT7 is a follow-up enzyme that transfers GalNAc to Ser/Thr that is already GalNAcylated.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q86SF2 
NCBI GeneID:   
51809
GlyMap GeneID:   
51809
DNA aRefSeq:   
NM_017423.2 
Protein RefSeq:   
NP_059119.2 
BRENDA:   
Kinetic info.
OMIM number:   
605005
GeneCards database:   
GALNT7
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3937 61-68 -0.647 99.0 -0.647 99.0 noncon
hsa-miR-4715-3p 1861-1868 -0.571 99.0 -0.562 99.0 noncon
hsa-miR-6874-5p 102-109 -0.429 98.0 -0.429 98.0 noncon
hsa-miR-4633-3p 101-108 -0.419 99.0 -0.419 99.0 noncon
hsa-miR-6500-5p 101-108 -0.411 99.0 -0.411 99.0 noncon
hsa-miR-6806-5p 1393-1400 -0.406 94.0 -0.4 96.0 noncon
hsa-miR-6868-5p 1517-1524 -0.398 98.0 -0.393 99.0 noncon
hsa-miR-6873-3p 1760-1767 -0.395 98.0 -0.389 98.0 noncon
hsa-miR-154-5p 19-26 -0.375 98.0 -0.375 99.0 noncon
hsa-miR-4736 881-888 -0.372 98.0 -0.367 99.0 noncon
hsa-miR-7150 882-889 -0.355 97.0 -0.35 98.0 noncon
hsa-miR-338-5p 2233-2240 -0.347 99.0 -0.332 99.0 noncon
hsa-miR-660-5p 1891-1898 -0.346 97.0 -0.341 98.0 noncon
hsa-miR-4315 927-934 -0.342 93.0 -0.337 94.0 noncon
hsa-miR-34c-5p 459-466 -0.339 93.0 -0.334 95.0 con
hsa-miR-449b-5p 459-466 -0.339 93.0 -0.334 95.0 con
hsa-miR-1910-5p 50-57 -0.332 97.0 -0.332 97.0 noncon
hsa-miR-3605-5p 1616-1623 -0.323 95.0 -0.319 96.0 noncon
hsa-miR-497-5p 503-509 -0.323 97.0 -0.319 97.0 con
hsa-miR-449a 459-466 -0.321 93.0 -0.317 94.0 con
hsa-miR-34a-5p 459-466 -0.321 93.0 -0.317 94.0 con
hsa-miR-642a-5p 1546-1553 -0.32 98.0 -0.316 98.0 noncon
hsa-miR-153-3p 2069-2075 -0.318 96.0 -0.314 97.0 con
hsa-miR-6803-3p 931-937 -0.315 90.0 -0.311 92.0 noncon
hsa-miR-8081 1602-1609 -0.31 96.0 -0.306 97.0 noncon
hsa-miR-4540 1149-1155 -0.309 94.0 -0.305 96.0 noncon
hsa-miR-4317 1864-1871 -0.299 95.0 -0.295 96.0 noncon
hsa-miR-4772-5p 121-128 -0.299 94.0 -0.299 96.0 noncon
hsa-miR-424-5p 503-509 -0.29 95.0 -0.286 96.0 con
hsa-miR-7-5p 825-832 -0.289 96.0 -0.285 97.0 noncon
hsa-miR-6838-5p 503-509 -0.283 94.0 -0.279 96.0 con
hsa-miR-15b-5p 503-509 -0.282 94.0 -0.278 96.0 con
hsa-miR-15a-5p 503-509 -0.282 94.0 -0.278 96.0 con
hsa-miR-27b-3p 148-154 -0.28 96.0 -0.28 97.0 con
hsa-miR-27a-3p 148-154 -0.28 96.0 -0.28 97.0 con
hsa-miR-3145-5p 379-386 -0.277 97.0 -0.275 98.0 noncon
hsa-miR-3681-3p 148-154 -0.277 97.0 -0.277 97.0 con
hsa-miR-4459 118-125 -0.277 97.0 -0.277 98.0 noncon
hsa-miR-570-5p 202-209 -0.274 97.0 -0.272 98.0 noncon
hsa-miR-548ai 202-209 -0.274 97.0 -0.272 98.0 noncon
hsa-miR-4531 872-879 -0.273 97.0 -0.269 97.0 noncon
hsa-miR-6833-3p 1761-1767 -0.266 96.0 -0.262 96.0 noncon
hsa-miR-128-3p 148-154 -0.264 97.0 -0.264 97.0 con
hsa-miR-4319 325-331 -0.262 94.0 -0.26 95.0 con
hsa-miR-125b-5p 325-331 -0.262 93.0 -0.26 95.0 con
hsa-miR-16-5p 503-509 -0.26 93.0 -0.257 95.0 con
hsa-miR-195-5p 503-509 -0.26 93.0 -0.257 95.0 con
hsa-miR-30c-5p 221-228 -0.259 92.0 -0.257 94.0 con
hsa-miR-153-3p 1841-1847 -0.259 94.0 -0.256 96.0 con
hsa-miR-30b-5p 221-228 -0.259 92.0 -0.257 94.0 con
hsa-miR-4804-3p 1457-1464 -0.258 97.0 -0.255 98.0 noncon
hsa-miR-363-3p 1903-1909 -0.252 94.0 -0.249 96.0 con
hsa-miR-92a-3p 1903-1909 -0.251 94.0 -0.248 96.0 con
hsa-miR-92b-3p 1903-1909 -0.251 95.0 -0.248 96.0 con