Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• A series of reactions occur on the core M3 O-mannosyl trisaccharide of α-dystroglycan (DAG1), and these elongate the core structure.
• Among these, first, two phospho-ribitols are added to the trisaccharide core. The first phospho-ribitol is added to GalNAc by FKTN/fukutin. The second ribitol is added by Fukutin-related protein/FKRP. Together, this results in the ribose 5-phosphate tandem repeat of DAG1.
• This unit is then primed by TMEM5 () and B3GAT1 (formerly B4GAT1).
• The core M3 structure can then be further extended by repeating GlcAβ(1-3)Xylα(1-3) units. This polymerization bifunctional GTs, LARGE1 (formerly LARGE) and/or its paralog LARGE2 (formerly GYLTL1B) in the Golgi apparatus.