GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
A4GNT
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
B3GALNT2
B3GALT1
B3GALT2
B3GALT5
B3GAT1
B3GAT2
B3GLCT
B3GNT2
B3GNT3
B3GNT4
B3GNT6
B3GNT7
B3GNT8
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
C1GALT1
C1GALT1C1
CHST1
CHST10
CHST2
CHST3
CHST4
CHST5
CHST8
CHST9
CMAS
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
EDEM1
EDEM2
EDEM3
ENGASE
EOGT
FKRP
FKTN
FPGT
FUCA1
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
GAL3ST2
GAL3ST3
GAL3ST4
GALNT1
GALNT10
GALNT11
GALNT12
GALNT13
GALNT14
GALNT15
GALNT16
GALNT17
GALNT18
GALNT2
GALNT3
GALNT4
GALNT5
GALNT6
GALNT7
GALNT8
GALNT9
GALNTL6
GANAB
GCNT1
GCNT2
GCNT3
GCNT4
GNPNAT1
GNPTAB
GNPTG
GXYLT1
GXYLT2
LFNG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MFNG
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MGAT5B
MOGS
NAGK
NAGPA
NEU1
NEU2
NEU3
NEU4
OGT
POFUT1
POFUT2
POGLUT1
POGLUT2
POGLUT3
POMGNT1
POMGNT2
POMT1
POMT2
PRKCSH
RFNG
RPN1
RPN2
RXYLT1
ST3GAL1
ST3GAL2
ST3GAL3
ST3GAL4
ST3GAL6
ST6GAL1
ST6GAL2
ST6GALNAC1
ST6GALNAC2
ST6GALNAC3
ST6GALNAC4
ST8SIA2
ST8SIA3
ST8SIA4
ST8SIA6
STT3A
STT3B
TMTC1
TMTC2
TMTC3
TMTC4
UGGT1
UGGT2
XXYLT1
Pathway Map
FPGT



General Information
Gene Symbol:   
FPGT
Protein name:   
Fucose-1-phosphate guanylyltransferase
Enzyme Class:   
CAZy Family:   
E.C. No:   
2.7.7.30
Tissues:   
Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

Fuc(1P) → GDP-Fuc
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-6787639
Related Database
Organism:   
Homo sapiens
Uniprot:   
O14772 
NCBI GeneID:   
8790
GlyMap GeneID:   
8790
DNA aRefSeq:   
NM_001199328.2 
Protein RefSeq:   
NP_001186257.2 
BRENDA:   
Kinetic info.
OMIM number:   
603609
GeneCards database:   
FPGT
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), O-linked (other)
Compartment:  
     
Substrate:  
     Fuc(1P)
Product:  
     GDP-Fuc
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-1287-3p 1431-1438 -0.603 99.0 -0.277 95.0 noncon
hsa-miR-4757-3p 2282-2289 -0.544 98.0 0.0 0.0 noncon
hsa-miR-3138 1306-1313 -0.525 98.0 -0.245 90.0 noncon
hsa-miR-3138 1593-1600 -0.51 98.0 -0.238 89.0 noncon
hsa-miR-2276-3p 1703-1710 -0.51 99.0 -0.238 98.0 noncon
hsa-miR-3189-3p 1649-1656 -0.506 99.0 -0.237 95.0 noncon
hsa-miR-431-5p 92-99 -0.499 99.0 -0.499 99.0 con
hsa-miR-6757-5p 292-299 -0.491 99.0 -0.253 95.0 noncon
hsa-miR-187-5p 571-578 -0.468 99.0 -0.242 97.0 noncon
hsa-miR-1290 3320-3327 -0.461 99.0 0.0 0.0 noncon
hsa-miR-6128 499-506 -0.454 99.0 -0.235 98.0 noncon
hsa-miR-9-3p 3313-3320 -0.45 99.0 0.0 0.0 noncon
hsa-miR-642b-5p 411-418 -0.448 98.0 -0.233 95.0 noncon
hsa-miR-4690-5p 3147-3154 -0.446 99.0 0.0 0.0 noncon
hsa-miR-1226-3p 1315-1322 -0.444 99.0 -0.21 94.0 noncon
hsa-miR-6888-5p 1236-1243 -0.437 99.0 -0.207 97.0 noncon
hsa-miR-4490 1268-1275 -0.431 98.0 -0.204 91.0 noncon
hsa-miR-4433b-3p 2876-2883 -0.429 99.0 0.0 0.0 noncon
hsa-miR-1246 3166-3173 -0.419 99.0 0.0 0.0 noncon
hsa-miR-147b 16-22 -0.418 97.0 -0.418 98.0 noncon
hsa-miR-7703 88-95 -0.417 99.0 -0.417 99.0 noncon
hsa-miR-4721 2345-2352 -0.41 97.0 0.0 0.0 noncon
hsa-miR-6780a-3p 199-206 -0.408 99.0 -0.213 94.0 noncon
hsa-miR-7-5p 2993-3000 -0.405 98.0 0.0 0.0 noncon
hsa-miR-613 497-504 -0.404 98.0 -0.211 93.0 noncon
hsa-miR-4689 826-833 -0.401 99.0 -0.191 93.0 noncon
hsa-miR-1251-3p 3265-3272 -0.399 98.0 0.0 0.0 noncon
hsa-miR-1226-5p 2346-2353 -0.395 98.0 0.0 0.0 noncon
hsa-miR-4257 998-1005 -0.394 99.0 -0.188 96.0 noncon
hsa-miR-501-5p 3278-3285 -0.39 98.0 0.0 0.0 noncon
hsa-miR-548ao-5p 138-145 -0.389 99.0 -0.389 99.0 noncon
hsa-miR-139-5p 897-904 -0.389 98.0 -0.186 95.0 noncon
hsa-miR-548ax 138-145 -0.389 98.0 -0.389 99.0 noncon
hsa-miR-3150b-3p 825-832 -0.388 99.0 -0.204 93.0 noncon
hsa-miR-6747-3p 1366-1373 -0.386 98.0 -0.184 93.0 noncon
hsa-miR-206 497-504 -0.386 98.0 -0.203 93.0 noncon
hsa-miR-1-3p 497-504 -0.386 98.0 -0.203 92.0 noncon
hsa-miR-4784 825-832 -0.38 98.0 -0.199 92.0 noncon
hsa-miR-3935 377-384 -0.38 98.0 -0.199 91.0 noncon
hsa-miR-518c-5p 501-508 -0.379 99.0 -0.199 95.0 noncon
hsa-miR-6733-3p 1842-1848 -0.371 98.0 -0.062 81.0 noncon
hsa-miR-507 590-597 -0.369 99.0 -0.194 97.0 noncon
hsa-miR-155-3p 888-895 -0.368 96.0 -0.176 86.0 noncon
hsa-miR-6513-3p 1072-1079 -0.356 99.0 -0.171 95.0 noncon
hsa-miR-4668-5p 1645-1652 -0.356 99.0 -0.171 93.0 noncon
hsa-miR-1255b-2-3p 1171-1178 -0.356 98.0 -0.171 94.0 noncon
hsa-miR-3675-3p 456-463 -0.355 99.0 -0.187 96.0 noncon
hsa-miR-4774-3p 2852-2859 -0.352 98.0 0.0 0.0 noncon
hsa-miR-4714-5p 879-886 -0.351 98.0 -0.169 92.0 noncon
hsa-miR-6499-3p 1843-1849 -0.347 99.0 -0.058 84.0 noncon
hsa-miR-4503 60-67 -0.345 97.0 -0.345 98.0 noncon
hsa-miR-3674 379-386 -0.344 97.0 -0.182 89.0 noncon
hsa-miR-4519 1844-1850 -0.341 98.0 -0.057 74.0 noncon
hsa-miR-4279 2921-2928 -0.339 98.0 0.0 0.0 noncon
hsa-miR-6076 167-173 -0.339 97.0 -0.179 93.0 noncon
hsa-miR-6894-3p 1364-1370 -0.338 98.0 -0.163 93.0 noncon
hsa-miR-4796-5p 1217-1224 -0.338 96.0 -0.163 86.0 noncon
hsa-miR-6505-5p 625-632 -0.338 99.0 -0.179 95.0 noncon
hsa-miR-3682-5p 1583-1590 -0.336 97.0 -0.162 92.0 noncon
hsa-miR-4276 531-538 -0.335 97.0 -0.177 92.0 noncon
hsa-miR-183-5p.1 1779-1785 -0.333 97.0 -0.056 78.0 noncon
hsa-miR-8071 2042-2048 -0.333 96.0 0.0 0.0 noncon
hsa-miR-6797-3p 167-173 -0.327 97.0 -0.173 93.0 noncon
hsa-miR-183-5p.2 1778-1784 -0.325 95.0 -0.055 69.0 noncon
hsa-miR-6858-5p 826-833 -0.325 98.0 -0.157 93.0 noncon
hsa-miR-5004-3p 3322-3328 -0.325 96.0 0.0 0.0 noncon
hsa-miR-3169 1245-1251 -0.324 97.0 -0.157 89.0 noncon
hsa-miR-3154 2170-2177 -0.323 98.0 0.0 0.0 noncon
hsa-miR-5196-3p 1718-1724 -0.322 97.0 -0.156 91.0 noncon
hsa-miR-548ba 3241-3248 -0.321 98.0 0.0 0.0 noncon
hsa-miR-8067 423-430 -0.317 98.0 -0.168 94.0 noncon
hsa-miR-6508-5p 423-430 -0.312 99.0 -0.166 95.0 noncon
hsa-miR-452-3p 1272-1279 -0.309 98.0 -0.15 92.0 noncon
hsa-miR-668-3p 275-281 -0.307 96.0 -0.163 92.0 noncon
hsa-miR-628-5p 326-332 -0.307 97.0 -0.163 93.0 noncon
hsa-miR-4740-5p 1244-1250 -0.307 95.0 -0.149 84.0 noncon
hsa-miR-4720-3p 38-44 -0.302 97.0 -0.302 98.0 noncon
hsa-miR-557 590-597 -0.301 99.0 -0.16 97.0 noncon
hsa-miR-5584-3p 981-988 -0.299 98.0 -0.145 94.0 noncon
hsa-miR-492 2218-2224 -0.299 93.0 0.0 0.0 noncon
hsa-miR-5580-3p 1060-1067 -0.298 99.0 -0.145 96.0 noncon
hsa-miR-6816-3p 2220-2227 -0.296 98.0 0.0 0.0 noncon
hsa-miR-3660 124-130 -0.296 97.0 -0.296 98.0 noncon
hsa-miR-653-3p 793-800 -0.296 97.0 -0.158 94.0 noncon
hsa-miR-4288 1350-1356 -0.293 96.0 -0.142 90.0 noncon
hsa-miR-5590-5p 77-83 -0.293 97.0 -0.293 98.0 noncon
hsa-miR-3606-5p 1212-1218 -0.293 95.0 -0.142 86.0 noncon
hsa-miR-223-5p 1392-1399 -0.291 95.0 -0.141 88.0 noncon
hsa-miR-548ag 3241-3248 -0.289 97.0 0.0 0.0 noncon
hsa-miR-548ai 3241-3248 -0.289 97.0 0.0 0.0 noncon
hsa-miR-570-5p 3241-3248 -0.289 97.0 0.0 0.0 noncon
hsa-miR-362-3p 2606-2613 -0.289 98.0 0.0 0.0 noncon
hsa-miR-329-3p 3136-3143 -0.288 98.0 0.0 0.0 noncon
hsa-miR-202-5p 1124-1131 -0.284 97.0 -0.138 89.0 noncon
hsa-miR-185-5p 823-829 -0.283 96.0 -0.151 87.0 noncon
hsa-miR-4306 823-829 -0.283 96.0 -0.151 87.0 noncon
hsa-miR-888-5p 489-496 -0.281 98.0 -0.15 94.0 noncon
hsa-miR-3685 889-895 -0.281 98.0 -0.137 94.0 noncon
hsa-miR-362-3p 3136-3143 -0.28 98.0 0.0 0.0 noncon
hsa-miR-7109-3p 781-787 -0.28 96.0 -0.149 91.0 noncon
hsa-miR-3137 2138-2145 -0.28 96.0 0.0 0.0 noncon
hsa-miR-1178-3p 2694-2701 -0.279 96.0 0.0 0.0 noncon
hsa-miR-4662b 770-776 -0.279 98.0 -0.149 93.0 noncon
hsa-miR-599 1037-1044 -0.279 98.0 -0.136 91.0 noncon
hsa-miR-6780a-3p 1716-1722 -0.277 96.0 -0.135 87.0 noncon
hsa-miR-3529-3p 568-575 -0.274 98.0 -0.146 93.0 noncon
hsa-miR-3123 3256-3263 -0.273 99.0 0.0 0.0 noncon
hsa-miR-329-3p 2606-2613 -0.273 98.0 0.0 0.0 noncon
hsa-miR-4684-5p 455-461 -0.272 97.0 -0.145 93.0 noncon
hsa-miR-4738-3p 2190-2197 -0.272 98.0 0.0 0.0 noncon
hsa-miR-5690 2413-2419 -0.27 97.0 0.0 0.0 noncon
hsa-miR-6508-3p 1340-1346 -0.268 95.0 -0.131 88.0 noncon
hsa-miR-8087 1483-1490 -0.267 98.0 -0.13 96.0 noncon
hsa-miR-4782-3p 2962-2968 -0.264 93.0 0.0 0.0 noncon
hsa-miR-219a-5p 2962-2968 -0.264 93.0 0.0 0.0 noncon
hsa-miR-584-3p 203-209 -0.264 95.0 -0.141 89.0 noncon
hsa-miR-101-5p 401-407 -0.261 97.0 -0.14 94.0 noncon
hsa-miR-4662a-5p 1429-1435 -0.261 95.0 -0.128 86.0 noncon
hsa-miR-6083 129-136 -0.26 99.0 -0.26 99.0 noncon
hsa-miR-1236-5p 2874-2880 -0.259 94.0 0.0 0.0 noncon
hsa-miR-3074-5p 1368-1375 -0.258 98.0 -0.126 95.0 noncon
hsa-miR-562 1550-1556 -0.257 96.0 -0.126 91.0 noncon
hsa-miR-20a-3p 1347-1354 -0.256 95.0 -0.125 89.0 noncon
hsa-miR-4465 1859-1866 -0.254 97.0 0.0 0.0 noncon
hsa-miR-338-5p 470-477 -0.254 98.0 -0.136 96.0 noncon
hsa-miR-222-3p 572-578 -0.253 92.0 -0.136 84.0 noncon
hsa-miR-221-3p 572-578 -0.253 93.0 -0.136 84.0 noncon
hsa-miR-6766-3p 2962-2968 -0.253 93.0 0.0 0.0 noncon
hsa-miR-3682-3p 1972-1979 -0.253 95.0 0.0 0.0 noncon
hsa-miR-3667-5p 873-879 -0.252 95.0 -0.123 88.0 noncon
hsa-miR-582-5p 832-839 -0.252 96.0 -0.123 91.0 noncon
hsa-miR-4800-5p 1307-1313 -0.252 90.0 -0.123 79.0 noncon