GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
A3GALT2
A4GALT
A4GNT
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
B3GALNT1
B3GALNT2
B3GALT1
B3GALT2
B3GALT4
B3GALT5
B3GAT1
B3GAT2
B3GNT2
B3GNT3
B3GNT4
B3GNT5
B3GNT6
B3GNT7
B3GNT8
B4GALNT1
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
B4GALT6
C1GALT1
C1GALT1C1
CHST1
CHST10
CHST2
CHST3
CHST4
CHST5
CHST8
CHST9
CMAS
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
EDEM1
EDEM2
EDEM3
ENGASE
FPGT
FUCA1
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
GAL3ST1
GAL3ST2
GAL3ST3
GAL3ST4
GALNT1
GALNT10
GALNT11
GALNT12
GALNT13
GALNT14
GALNT15
GALNT16
GALNT17
GALNT18
GALNT2
GALNT3
GALNT4
GALNT5
GALNT6
GALNT7
GALNT8
GALNT9
GALNTL6
GANAB
GBGT1
GCNT1
GCNT2
GCNT3
GCNT4
GNPNAT1
GNPTAB
GNPTG
HEXA
HEXB
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MOGS
NAGA
NAGK
NAGPA
NEU1
NEU2
NEU3
NEU4
PRKCSH
RPN1
RPN2
ST3GAL1
ST3GAL2
ST3GAL3
ST3GAL4
ST3GAL5
ST3GAL6
ST6GAL1
ST6GAL2
ST6GALNAC1
ST6GALNAC2
ST6GALNAC3
ST6GALNAC4
ST6GALNAC5
ST6GALNAC6
ST8SIA1
ST8SIA2
ST8SIA3
ST8SIA4
ST8SIA5
ST8SIA6
STT3A
STT3B
UGCG
UGGT1
UGGT2
UGT8
Pathway Map
B3GAT2



General Information
Gene Symbol:   
B3GAT2
Protein name:   
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT43
E.C. No:   
2.4.1.135
Organs:   
Reaction (SNFG):   
+
→
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
K10157
KEGG Pathway:   
ko00515  ko01100 
Reactome:   
R-HSA-1971475
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9NPZ5 
NCBI GeneID:   
135152
GlyMap GeneID:   
135152
DNA aRefSeq:   
NM_080742.2 
Protein RefSeq:   
NP_542780.1 
BRENDA:   
Kinetic info.
OMIM number:   
607497
GeneCards database:   
B3GAT2
Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type), GSL
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Gal(b1-4)GlcNAc(b1-?)
Product:  
     GlcA(b1-3)Gal(b1-4)GlcNAc(b1-?)
Constraints:  
     !GlcA(b1-3)Gal(b1-4)GlcNAc(b1-?)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 2 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6793-5p 478-485 -0.479 98.0 -0.479 99.0 noncon
hsa-miR-6759-5p 479-486 -0.468 99.0 -0.468 99.0 noncon
hsa-miR-5004-3p 4871-4878 -0.462 99.0 -0.052 72.0 noncon
hsa-miR-3665 3739-3746 -0.444 98.0 -0.424 98.0 noncon
hsa-miR-593-5p 4926-4933 -0.435 97.0 -0.049 51.0 noncon
hsa-miR-1178-5p 3294-3301 -0.424 98.0 -0.405 98.0 noncon
hsa-miR-202-5p 465-472 -0.421 99.0 -0.421 99.0 noncon
hsa-miR-1825 1572-1579 -0.413 99.0 -0.395 99.0 noncon
hsa-miR-4718 106-113 -0.41 97.0 -0.41 98.0 noncon
hsa-miR-510-5p 3944-3951 -0.394 99.0 -0.377 99.0 noncon
hsa-miR-644a 3985-3992 -0.392 97.0 -0.375 98.0 noncon
hsa-miR-558 4162-4169 -0.388 98.0 -0.371 98.0 noncon
hsa-miR-508-3p 4977-4984 -0.388 98.0 -0.044 58.0 noncon
hsa-miR-6832-5p 227-234 -0.386 98.0 -0.386 98.0 noncon
hsa-miR-7705 1028-1035 -0.377 98.0 -0.361 98.0 noncon
hsa-miR-193b-3p 2279-2286 -0.367 96.0 -0.351 97.0 noncon
hsa-miR-193a-3p 2279-2286 -0.367 96.0 -0.351 97.0 noncon
hsa-miR-4645-3p 568-575 -0.357 97.0 -0.349 98.0 noncon
hsa-miR-181a-3p 3670-3677 -0.344 91.0 -0.329 94.0 noncon
hsa-miR-660-5p 1222-1229 -0.343 97.0 -0.328 98.0 noncon
hsa-miR-5591-3p 1223-1230 -0.343 97.0 -0.328 98.0 noncon
hsa-miR-644a 1527-1534 -0.336 96.0 -0.322 97.0 noncon
hsa-miR-5689 1956-1963 -0.329 91.0 -0.315 94.0 noncon
hsa-miR-145-3p 4898-4905 -0.328 98.0 -0.038 71.0 noncon
hsa-miR-6868-5p 3329-3336 -0.326 97.0 -0.312 97.0 noncon
hsa-miR-3171 459-466 -0.319 95.0 -0.319 97.0 noncon
hsa-miR-4531 310-317 -0.318 98.0 -0.318 98.0 noncon
hsa-miR-3664-5p 1586-1593 -0.31 98.0 -0.297 98.0 noncon
hsa-miR-3137 70-77 -0.308 97.0 -0.308 97.0 noncon
hsa-miR-7111-3p 1044-1051 -0.307 97.0 -0.294 97.0 noncon
hsa-miR-8089 4752-4759 -0.307 96.0 -0.036 55.0 noncon
hsa-miR-21-5p 166-173 -0.307 97.0 -0.307 98.0 noncon
hsa-miR-138-5p 3070-3077 -0.306 93.0 -0.293 94.0 noncon
hsa-miR-654-5p 3596-3603 -0.294 95.0 -0.282 95.0 noncon
hsa-miR-7702 1810-1817 -0.293 95.0 -0.281 96.0 noncon
hsa-miR-760 2913-2920 -0.29 93.0 -0.278 94.0 noncon
hsa-miR-875-5p 982-988 -0.288 96.0 -0.276 97.0 con
hsa-miR-541-3p 3596-3603 -0.286 94.0 -0.274 95.0 noncon
hsa-miR-5587-5p 2589-2596 -0.284 95.0 -0.272 96.0 noncon
hsa-miR-7109-3p 1493-1500 -0.281 96.0 -0.269 97.0 noncon
hsa-miR-219b-5p 133-139 -0.28 92.0 -0.28 94.0 noncon
hsa-miR-4667-5p 4752-4759 -0.28 95.0 -0.033 50.0 noncon
hsa-miR-7107-3p 1181-1188 -0.279 93.0 -0.267 95.0 noncon
hsa-miR-4445-5p 4978-4984 -0.279 94.0 -0.033 59.0 noncon
hsa-miR-3684 493-499 -0.278 91.0 -0.272 94.0 noncon
hsa-miR-5579-3p 167-174 -0.277 97.0 -0.277 98.0 noncon
hsa-miR-4679 3806-3813 -0.276 97.0 -0.264 98.0 noncon
hsa-miR-5579-5p 1591-1598 -0.275 95.0 -0.263 96.0 noncon
hsa-miR-221-3p 4021-4028 -0.273 94.0 -0.262 95.0 noncon
hsa-miR-1251-5p 2698-2705 -0.272 95.0 -0.261 96.0 noncon
hsa-miR-1266-5p 3898-3905 -0.271 96.0 -0.26 97.0 noncon
hsa-miR-3130-3p 16-22 -0.271 97.0 -0.271 98.0 noncon
hsa-miR-3652 27-34 -0.271 97.0 -0.271 97.0 noncon
hsa-miR-1245b-3p 124-131 -0.271 97.0 -0.271 98.0 noncon
hsa-miR-141-5p 246-252 -0.27 96.0 -0.27 97.0 noncon
hsa-miR-4724-3p 4916-4923 -0.268 97.0 -0.032 79.0 noncon
hsa-miR-4430 27-34 -0.268 97.0 -0.268 97.0 noncon
hsa-miR-222-3p 4021-4028 -0.265 93.0 -0.254 95.0 noncon
hsa-miR-544a 651-658 -0.264 95.0 -0.259 96.0 noncon
hsa-miR-6753-3p 1181-1188 -0.263 93.0 -0.252 94.0 noncon
hsa-miR-4700-5p 4752-4759 -0.262 95.0 -0.031 51.0 noncon
hsa-miR-4797-5p 4202-4209 -0.258 98.0 -0.247 99.0 noncon
hsa-miR-218-5p 807-813 -0.256 93.0 -0.245 94.0 con
hsa-miR-3127-5p 3680-3687 -0.256 92.0 -0.245 94.0 noncon
hsa-miR-27a-5p 4958-4964 -0.255 92.0 -0.03 41.0 noncon
hsa-miR-3145-5p 757-764 -0.255 97.0 -0.25 98.0 noncon
hsa-miR-4687-3p 3981-3988 -0.254 94.0 -0.243 95.0 noncon
hsa-miR-4686 4611-4618 -0.251 94.0 -0.03 60.0 noncon
hsa-miR-877-3p 48-55 -0.25 93.0 -0.25 95.0 noncon