GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT14



General Information
Gene Symbol:   
GALNT14
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 14
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Catalyzes the initiation of O-linked oligosaccharide biosynthesis. Part of the ~20 member ppGalNAcT family.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q96FL9 
NCBI GeneID:   
79623
GlyMap GeneID:   
79623
DNA aRefSeq:   
NM_001253826.1 
Protein RefSeq:   
NP_001240755.1 
BRENDA:   
Kinetic info.
OMIM number:   
608225
GeneCards database:   
GALNT14
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 200 180 160 140 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000349752 ENST00000464038 TP63 GATA2 SMAD4 CTCF
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4485-3p 216-223 -0.791 99.0 -0.791 99.0 noncon
hsa-miR-8065 300-307 -0.571 99.0 -0.571 99.0 noncon
hsa-miR-6885-5p 125-132 -0.553 96.0 -0.553 97.0 noncon
hsa-miR-1225-3p 184-191 -0.553 99.0 -0.553 99.0 noncon
hsa-miR-4654 199-206 -0.494 99.0 -0.494 99.0 noncon
hsa-miR-328-5p 125-132 -0.451 95.0 -0.451 96.0 noncon
hsa-miR-198 429-436 -0.45 99.0 -0.001 22.0 noncon
hsa-miR-6511b-5p 80-87 -0.448 98.0 -0.448 99.0 noncon
hsa-miR-4769-5p 199-206 -0.442 99.0 -0.442 99.0 noncon
hsa-miR-6838-3p 359-366 -0.441 99.0 -0.441 99.0 noncon
hsa-miR-6811-5p 80-87 -0.437 98.0 -0.437 99.0 noncon
hsa-miR-516b-3p 309-316 -0.434 98.0 -0.434 99.0 noncon
hsa-miR-516a-3p 309-316 -0.434 98.0 -0.434 99.0 noncon
hsa-miR-7162-5p 309-316 -0.418 98.0 -0.418 99.0 noncon
hsa-miR-125a-5p 149-156 -0.404 98.0 -0.404 98.0 con
hsa-miR-6809-3p 408-415 -0.401 99.0 -0.401 99.0 noncon
hsa-miR-3176 325-332 -0.399 99.0 -0.399 99.0 noncon
hsa-miR-7152-3p 46-53 -0.397 98.0 -0.397 98.0 noncon
hsa-miR-4319 149-156 -0.396 98.0 -0.396 98.0 con
hsa-miR-6851-3p 21-28 -0.39 98.0 -0.39 98.0 noncon
hsa-miR-3922-3p 325-332 -0.389 99.0 -0.389 99.0 noncon
hsa-miR-4753-3p 407-414 -0.388 99.0 -0.388 99.0 noncon
hsa-miR-125b-5p 149-156 -0.388 97.0 -0.388 98.0 con
hsa-miR-4261 391-398 -0.378 98.0 -0.378 99.0 noncon
hsa-miR-6134 88-95 -0.373 97.0 -0.373 98.0 noncon
hsa-miR-4515 228-234 -0.371 97.0 -0.371 97.0 noncon
hsa-miR-6780a-3p 160-167 -0.369 98.0 -0.369 98.0 noncon
hsa-miR-6888-3p 264-271 -0.367 98.0 -0.367 98.0 noncon
hsa-miR-6772-3p 137-144 -0.329 96.0 -0.329 97.0 noncon
hsa-miR-6748-3p 133-140 -0.31 95.0 -0.31 96.0 noncon
hsa-miR-7113-5p 41-48 -0.306 97.0 -0.306 97.0 noncon
hsa-miR-7162-3p 90-97 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-337-5p 217-223 -0.289 90.0 -0.289 94.0 noncon
hsa-miR-299-3p 201-207 -0.28 95.0 -0.28 97.0 noncon
hsa-miR-6852-5p 128-135 -0.276 96.0 -0.276 97.0 noncon
hsa-miR-549a 422-428 -0.275 94.0 -0.275 96.0 noncon
hsa-miR-193b-3p 236-242 -0.265 90.0 -0.265 93.0 noncon
hsa-miR-193a-3p 236-242 -0.265 90.0 -0.265 93.0 noncon
hsa-miR-6836-3p 116-122 -0.26 94.0 -0.26 96.0 noncon
hsa-miR-3922-3p 355-361 -0.258 96.0 -0.258 97.0 noncon
hsa-miR-328-3p 22-28 -0.254 93.0 -0.254 95.0 noncon