GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
B3GALNT2
B3GALT2
B3GAT1
B3GAT2
B3GNT2
B3GNT4
B3GNT7
B3GNT8
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
CHST1
CHST10
CHST2
CHST3
CHST4
CHST5
CHST8
CHST9
CMAS
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
EDEM1
EDEM2
EDEM3
ENGASE
FPGT
FUCA1
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
GAL3ST2
GAL3ST3
GANAB
GCNT2
GNPNAT1
GNPTAB
GNPTG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MOGS
NAGK
NAGPA
NEU1
NEU2
NEU3
NEU4
PRKCSH
RPN1
RPN2
ST3GAL3
ST3GAL4
ST3GAL6
ST6GAL1
ST6GAL2
ST8SIA2
ST8SIA3
ST8SIA4
STT3A
STT3B
UGGT1
UGGT2
Pathway Map
MOGS



General Information
Gene Symbol:   
MOGS
Protein name:   
Mannosyl-oligosaccharide glucosidase
Enzyme Class:   
Glycosidase
CAZy Family:   
GH63
E.C. No:   
3.2.1.106
Organs:   
Reaction (SNFG):   
MOGS
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Removes α(1-2)Glc from the nonreducing terminal end of the α1,3Man branch to produce Glc2Man9GlcNAc2.

Related Pathway
KEGG ORTHOLOGY:   
K01228
KEGG Pathway:   
ko00510  ko01100  ko04141 
Reactome:   
R-HSA-4793954
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q13724 
NCBI GeneID:   
7841
GlyMap GeneID:   
7841
DNA aRefSeq:   
NM_001146158.1 
Protein RefSeq:   
NP_001139630.1 
BRENDA:   
Kinetic info.
OMIM number:   
601336
GeneCards database:   
MOGS
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     Glc(a1-2)Glc(a1-3)Glc(a1-3)Man(a1-2)
Product:  
     Glc(a1-3)Glc(a1-3)Man(a1-2)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-6887-3p 1706-1713 -0.563 99.0 -0.549 99.0 noncon
hsa-miR-6861-3p 106-113 -0.516 99.0 -0.516 99.0 noncon
hsa-miR-6743-3p 963-970 -0.516 96.0 -0.503 97.0 noncon
hsa-miR-7109-5p 713-720 -0.511 98.0 -0.498 98.0 noncon
hsa-miR-564 1541-1548 -0.463 97.0 -0.452 97.0 noncon
hsa-miR-210-5p 126-133 -0.443 98.0 -0.443 98.0 noncon
hsa-miR-6770-3p 1336-1342 -0.428 95.0 -0.418 96.0 noncon
hsa-miR-6749-5p 658-665 -0.426 96.0 -0.416 96.0 noncon
hsa-miR-1288-3p 699-706 -0.406 98.0 -0.396 98.0 noncon
hsa-miR-4763-5p 236-243 -0.398 94.0 -0.389 96.0 noncon
hsa-miR-128-1-5p 1212-1219 -0.39 98.0 -0.381 98.0 noncon
hsa-miR-6802-3p 1850-1857 -0.379 97.0 -0.37 98.0 noncon
hsa-miR-221-5p 79-86 -0.376 98.0 -0.376 99.0 noncon
hsa-miR-8073 79-86 -0.376 99.0 -0.376 99.0 noncon
hsa-miR-7106-3p 636-643 -0.36 96.0 -0.352 97.0 noncon
hsa-miR-299-3p 1837-1844 -0.359 98.0 -0.351 98.0 noncon
hsa-miR-4654 1835-1842 -0.358 98.0 -0.35 98.0 noncon
hsa-miR-361-3p 648-655 -0.346 97.0 -0.338 98.0 noncon
hsa-miR-6088 1810-1817 -0.344 98.0 -0.336 99.0 con
hsa-miR-4535 107-114 -0.34 97.0 -0.34 98.0 noncon
hsa-miR-615-5p 1286-1293 -0.34 95.0 -0.332 96.0 noncon
hsa-miR-6798-5p 57-64 -0.332 97.0 -0.332 97.0 noncon
hsa-miR-4646-3p 1745-1752 -0.33 95.0 -0.322 97.0 noncon
hsa-miR-4999-5p 141-148 -0.328 95.0 -0.328 97.0 noncon
hsa-miR-3157-5p 1678-1685 -0.327 97.0 -0.319 98.0 noncon
hsa-miR-4770 1810-1817 -0.326 98.0 -0.319 98.0 con
hsa-miR-579-5p 1612-1618 -0.323 91.0 -0.315 92.0 noncon
hsa-miR-518c-3p 290-296 -0.318 92.0 -0.311 94.0 noncon
hsa-miR-143-3p 1810-1817 -0.318 98.0 -0.311 98.0 con
hsa-miR-1913 128-134 -0.313 97.0 -0.313 97.0 noncon
hsa-miR-128-2-5p 1212-1219 -0.309 97.0 -0.302 98.0 noncon
hsa-miR-5187-5p 1833-1840 -0.307 95.0 -0.3 96.0 noncon
hsa-miR-4769-5p 1835-1842 -0.306 98.0 -0.299 98.0 noncon
hsa-miR-4660 1104-1111 -0.304 95.0 -0.297 96.0 noncon
hsa-miR-378j 1862-1869 -0.304 97.0 -0.297 97.0 noncon
hsa-miR-324-3p 128-134 -0.303 96.0 -0.303 97.0 noncon
hsa-miR-514a-5p 1865-1871 -0.297 98.0 -0.29 98.0 noncon
hsa-miR-6810-3p 125-131 -0.297 94.0 -0.297 96.0 noncon
hsa-miR-4685-5p 258-265 -0.294 95.0 -0.287 96.0 noncon
hsa-miR-3170 900-907 -0.294 95.0 -0.287 96.0 noncon
hsa-miR-6837-5p 258-265 -0.291 95.0 -0.284 96.0 noncon
hsa-miR-1537-5p 484-491 -0.287 92.0 -0.28 94.0 noncon
hsa-miR-6839-5p 1862-1869 -0.286 97.0 -0.28 97.0 noncon
hsa-miR-518b 290-296 -0.285 90.0 -0.278 92.0 noncon
hsa-miR-518d-3p 290-296 -0.285 90.0 -0.278 92.0 noncon
hsa-miR-760 828-835 -0.284 93.0 -0.278 94.0 noncon
hsa-miR-4283 1349-1355 -0.282 92.0 -0.276 94.0 noncon
hsa-miR-6855-5p 900-907 -0.281 95.0 -0.275 96.0 noncon
hsa-miR-6801-3p 125-131 -0.276 92.0 -0.276 95.0 noncon
hsa-miR-103b 1248-1254 -0.271 93.0 -0.265 95.0 noncon
hsa-miR-518f-3p 290-296 -0.27 92.0 -0.264 94.0 noncon
hsa-miR-6752-3p 124-130 -0.27 92.0 -0.27 94.0 noncon
hsa-miR-518c-5p 1864-1870 -0.269 97.0 -0.263 97.0 noncon
hsa-miR-6886-3p 320-326 -0.268 92.0 -0.262 94.0 noncon
hsa-miR-1207-3p 308-315 -0.268 96.0 -0.262 97.0 noncon
hsa-miR-4418 1227-1234 -0.268 97.0 -0.262 98.0 noncon
hsa-miR-6855-3p 1254-1260 -0.266 95.0 -0.26 96.0 noncon
hsa-miR-4513 1254-1260 -0.266 95.0 -0.26 96.0 noncon
hsa-miR-6893-3p 144-150 -0.265 95.0 -0.265 96.0 noncon
hsa-miR-6880-5p 1476-1483 -0.264 91.0 -0.258 92.0 noncon
hsa-miR-6744-5p 1832-1838 -0.264 94.0 -0.258 95.0 noncon
hsa-miR-199b-3p 1687-1694 -0.263 93.0 -0.257 95.0 con
hsa-miR-199a-3p 1687-1694 -0.263 93.0 -0.257 95.0 con
hsa-miR-6729-3p 651-658 -0.261 93.0 -0.255 94.0 noncon
hsa-miR-6747-3p 205-212 -0.261 95.0 -0.255 96.0 noncon
hsa-miR-6773-5p 1061-1067 -0.261 91.0 -0.255 93.0 noncon
hsa-miR-1182 907-914 -0.259 96.0 -0.253 97.0 noncon
hsa-miR-4751 1500-1507 -0.259 92.0 -0.253 94.0 noncon
hsa-miR-661 202-209 -0.259 95.0 -0.253 96.0 noncon
hsa-miR-3194-5p 1018-1025 -0.256 93.0 -0.25 95.0 noncon
hsa-miR-509-5p 1227-1234 -0.255 97.0 -0.249 98.0 noncon
hsa-miR-6828-3p 441-448 -0.255 95.0 -0.249 96.0 noncon
hsa-miR-147a 1151-1158 -0.254 98.0 -0.248 99.0 noncon
hsa-miR-203a-5p 1148-1155 -0.253 92.0 -0.247 94.0 noncon