GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
B3GALNT2
B3GALT2
B3GAT1
B3GAT2
B3GNT2
B3GNT4
B3GNT7
B3GNT8
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
CHST1
CHST10
CHST2
CHST3
CHST4
CHST5
CHST8
CHST9
CMAS
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
EDEM1
EDEM2
EDEM3
ENGASE
FPGT
FUCA1
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
GAL3ST2
GAL3ST3
GANAB
GCNT2
GNPNAT1
GNPTAB
GNPTG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MOGS
NAGK
NAGPA
NEU1
NEU2
NEU3
NEU4
PRKCSH
RPN1
RPN2
ST3GAL3
ST3GAL4
ST3GAL6
ST6GAL1
ST6GAL2
ST8SIA2
ST8SIA3
ST8SIA4
STT3A
STT3B
UGGT1
UGGT2
Pathway Map
CTBS



General Information
Gene Symbol:   
CTBS
Protein name:   
Di-N-acetylchitobiase
Enzyme Class:   
Glycosidase
CAZy Family:   
GH18
E.C. No:   
3.2.1.*
Organs:   
Reaction (SNFG):   
CTBS
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Involved in the lysosomal degradation of N-linked glycans in the lysosome.
• Cleaves GlcNAc(b1-4)GlcNAc(b1-?)Asn.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
No Record
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q01459 
NCBI GeneID:   
1486
GlyMap GeneID:   
1486
DNA aRefSeq:   
NM_004388.2 
Protein RefSeq:   
NP_004379.1 
BRENDA:   
Kinetic info.
OMIM number:   
600873
GeneCards database:   
CTBS
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     
Substrate:  
     GlcNAc(b1-4)GlcNAc(b1-?)Asn
Product:  
     GlcNAc(b1-?))Asn
Constraints:  
     !Fuc(a1-6)
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-2114-3p 697-704 -0.527 99.0 -0.423 98.0 noncon
hsa-miR-6835-5p 1427-1434 -0.511 99.0 -0.411 98.0 noncon
hsa-miR-6823-3p 697-704 -0.49 99.0 -0.395 98.0 noncon
hsa-miR-6515-5p 432-439 -0.453 99.0 -0.366 98.0 noncon
hsa-let-7e-3p 97-103 -0.442 95.0 -0.442 97.0 noncon
hsa-miR-625-5p 423-430 -0.424 97.0 -0.343 95.0 noncon
hsa-miR-7515 292-299 -0.423 99.0 -0.342 98.0 noncon
hsa-miR-212-5p 1793-1800 -0.423 98.0 -0.342 98.0 con
hsa-miR-4665-5p 424-431 -0.415 97.0 -0.336 96.0 noncon
hsa-miR-4790-3p 1686-1693 -0.4 99.0 -0.324 98.0 noncon
hsa-miR-3115 4098-4105 -0.374 96.0 -0.051 59.0 noncon
hsa-miR-196b-5p 663-670 -0.37 97.0 -0.3 97.0 noncon
hsa-miR-196a-5p 663-670 -0.37 97.0 -0.3 96.0 noncon
hsa-miR-4703-3p 679-686 -0.362 97.0 -0.294 97.0 noncon
hsa-miR-3649 3962-3969 -0.362 96.0 -0.049 56.0 noncon
hsa-miR-643 4948-4955 -0.361 98.0 -0.049 70.0 noncon
hsa-miR-3691-3p 1666-1673 -0.357 98.0 -0.29 97.0 noncon
hsa-miR-1267 44-51 -0.352 98.0 -0.352 98.0 noncon
hsa-miR-433-3p 4671-4678 -0.338 98.0 -0.046 76.0 con
hsa-miR-6751-5p 1428-1434 -0.336 96.0 -0.273 95.0 noncon
hsa-miR-223-5p 150-157 -0.333 96.0 -0.271 96.0 noncon
hsa-miR-6853-3p 1472-1479 -0.328 97.0 -0.267 97.0 noncon
hsa-miR-3916 219-226 -0.326 98.0 -0.266 98.0 noncon
hsa-miR-1275 424-431 -0.318 96.0 -0.259 96.0 noncon
hsa-miR-5004-5p 162-169 -0.317 95.0 -0.258 94.0 noncon
hsa-miR-6733-3p 1016-1023 -0.308 97.0 -0.251 96.0 noncon
hsa-miR-3125 219-226 -0.308 98.0 -0.251 97.0 noncon
hsa-miR-6773-3p 1297-1304 -0.304 96.0 -0.248 95.0 noncon
hsa-miR-6864-5p 293-299 -0.302 96.0 -0.246 95.0 noncon
hsa-miR-4303 1408-1415 -0.3 97.0 -0.245 97.0 noncon
hsa-miR-3616-3p 5314-5320 -0.3 93.0 -0.041 46.0 noncon
hsa-miR-503-3p 1739-1746 -0.295 95.0 -0.241 95.0 noncon
hsa-miR-516a-5p 3353-3360 -0.295 92.0 -0.041 54.0 noncon
hsa-miR-4766-5p 266-273 -0.293 99.0 -0.239 99.0 noncon
hsa-miR-875-3p 1445-1452 -0.292 98.0 -0.238 97.0 noncon
hsa-miR-630 4059-4066 -0.289 95.0 -0.04 59.0 noncon
hsa-miR-6803-5p 1428-1434 -0.289 94.0 -0.236 93.0 noncon
hsa-miR-518a-5p 1545-1552 -0.288 98.0 -0.235 98.0 noncon
hsa-miR-527 1545-1552 -0.288 98.0 -0.235 98.0 noncon
hsa-miR-4320 591-598 -0.285 96.0 -0.233 95.0 noncon
hsa-miR-448 4929-4936 -0.285 97.0 -0.04 69.0 noncon
hsa-miR-4782-5p 594-601 -0.285 97.0 -0.233 96.0 noncon
hsa-miR-4638-3p 4990-4997 -0.28 94.0 -0.039 57.0 noncon
hsa-miR-4528 1469-1476 -0.28 99.0 -0.229 98.0 noncon
hsa-miR-668-3p 3035-3042 -0.279 95.0 -0.039 72.0 noncon
hsa-miR-5706 594-601 -0.277 96.0 -0.226 96.0 noncon
hsa-miR-4660 987-994 -0.276 94.0 -0.226 93.0 noncon
hsa-miR-6507-3p 5167-5174 -0.274 97.0 -0.038 79.0 noncon
hsa-miR-4309 521-527 -0.274 95.0 -0.224 95.0 noncon
hsa-miR-610 1569-1575 -0.271 94.0 -0.221 93.0 noncon
hsa-miR-4308 1107-1114 -0.269 97.0 -0.22 96.0 noncon
hsa-miR-542-3p 759-766 -0.268 96.0 -0.219 95.0 noncon
hsa-miR-4507 5292-5299 -0.266 94.0 -0.037 66.0 noncon
hsa-miR-95-5p 4384-4390 -0.263 98.0 -0.037 73.0 noncon
hsa-miR-154-5p 4680-4687 -0.261 96.0 -0.036 66.0 con
hsa-miR-6514-5p 522-529 -0.26 96.0 -0.213 96.0 noncon
hsa-miR-3118 3478-3485 -0.259 93.0 -0.036 58.0 noncon
hsa-miR-3064-3p 2395-2402 -0.259 92.0 -0.036 59.0 noncon
hsa-miR-1244 3425-3432 -0.25 93.0 -0.035 59.0 noncon