Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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No reaction | → |
• A multi-membrane protein ER membrane associated protein complex that mediates the en-bloc transfer of 14 sugar LLO to N-X-S/T motif in nascent polypeptide
• STT3 is the catalytic core of this complex
• Stt3 forms a complex with the accessory membrane proteins DDOST/OST48, RPN1/ribophorin I, RPN2/ribophorin II, DAD1, Ost4, TUSC3/N33 and MGAT1/IAP in mammals for maximal ativity.
• There are two STT3 genes: STT3A and STT3B. Human Stt3A and Stt3B have redundant functions in the co-translational N-glycosylation. Stt3B also mediates the post-translational N-glycosylation after some time, rather than just at the time when the protein enters the ER from the ribosome.
• Glc[0-3]Man[0-9]GlcNAc2β1-PP-Dol + Asn-Xaa-Ser/Thr -> Dol-PP + Glc[0-3]Man[0-9]GlcNAc2β1-Asn-Xaa-Ser/Thr.
ER | Cis- | Medial- | Trans- | TGN |
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miRNA Name | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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hsa-miR-3616-3p | 593-600 | -0.702 | 99.0 | -0.024 | 36.0 | noncon | |
hsa-miR-1226-5p | 594-601 | -0.65 | 99.0 | -0.003 | 43.0 | noncon | |
hsa-miR-532-3p | 117-124 | -0.57 | 99.0 | -0.57 | 99.0 | con | |
hsa-miR-4733-5p | 153-160 | -0.533 | 99.0 | -0.533 | 99.0 | noncon | |
hsa-miR-1915-5p | 36-43 | -0.505 | 98.0 | -0.505 | 99.0 | noncon | |
hsa-miR-4766-3p | 193-200 | -0.481 | 99.0 | -0.024 | 58.0 | noncon | |
hsa-miR-4524a-3p | 530-537 | -0.456 | 99.0 | -0.017 | 53.0 | noncon | |
hsa-miR-520g-3p | 185-192 | -0.453 | 99.0 | -0.453 | 99.0 | noncon | |
hsa-miR-520h | 185-192 | -0.453 | 99.0 | -0.453 | 99.0 | noncon | |
hsa-miR-8057 | 135-142 | -0.433 | 99.0 | -0.433 | 99.0 | noncon | |
hsa-miR-4790-5p | 581-587 | -0.425 | 95.0 | -0.016 | 35.0 | noncon | |
hsa-miR-6776-3p | 61-67 | -0.391 | 98.0 | -0.391 | 99.0 | noncon | |
hsa-miR-6887-3p | 41-47 | -0.376 | 95.0 | -0.376 | 96.0 | noncon | |
hsa-miR-6790-3p | 318-325 | -0.368 | 98.0 | -0.014 | 50.0 | noncon | |
hsa-miR-2682-3p | 461-468 | -0.353 | 98.0 | -0.014 | 49.0 | noncon | |
hsa-miR-6781-3p | 461-468 | -0.34 | 98.0 | -0.013 | 49.0 | noncon | |
hsa-miR-6746-3p | 309-315 | -0.339 | 90.0 | -0.013 | 22.0 | noncon | |
hsa-miR-504-3p | 499-506 | -0.331 | 97.0 | -0.013 | 60.0 | noncon | |
hsa-miR-125a-3p | 605-611 | -0.326 | 98.0 | 0.0 | 0.0 | noncon | |
hsa-miR-1976 | 440-447 | -0.319 | 97.0 | -0.013 | 68.0 | noncon | |
hsa-miR-532-3p | 146-152 | -0.318 | 98.0 | -0.318 | 98.0 | noncon | |
hsa-miR-1227-3p | 99-105 | -0.312 | 94.0 | -0.312 | 96.0 | noncon | |
hsa-miR-6747-3p | 438-445 | -0.301 | 97.0 | -0.012 | 49.0 | noncon | |
hsa-miR-212-5p | 138-144 | -0.298 | 96.0 | -0.298 | 97.0 | noncon | |
hsa-miR-1236-5p | 224-230 | -0.295 | 95.0 | -0.012 | 54.0 | noncon | |
hsa-miR-6787-3p | 481-488 | -0.291 | 98.0 | -0.012 | 62.0 | noncon | |
hsa-miR-552-3p | 408-415 | -0.29 | 96.0 | -0.012 | 43.0 | noncon | |
hsa-miR-4257 | 111-117 | -0.288 | 98.0 | -0.288 | 98.0 | noncon | |
hsa-miR-4667-3p | 40-46 | -0.284 | 96.0 | -0.284 | 97.0 | noncon | |
hsa-miR-662 | 89-95 | -0.283 | 91.0 | -0.283 | 94.0 | noncon | |
hsa-miR-5095 | 275-282 | -0.277 | 95.0 | -0.011 | 58.0 | noncon | |
hsa-miR-4712-3p | 231-237 | -0.273 | 97.0 | -0.011 | 49.0 | noncon | |
hsa-miR-6822-3p | 135-141 | -0.27 | 95.0 | -0.27 | 96.0 | noncon | |
hsa-miR-3118 | 222-228 | -0.267 | 93.0 | -0.011 | 40.0 | noncon | |
hsa-miR-196a-3p | 590-596 | -0.265 | 92.0 | -0.011 | 34.0 | noncon | |
hsa-miR-1260b | 145-151 | -0.264 | 93.0 | -0.264 | 95.0 | noncon | |
hsa-miR-1260a | 145-151 | -0.264 | 93.0 | -0.264 | 95.0 | noncon | |
hsa-miR-4713-5p | 118-124 | -0.263 | 95.0 | -0.263 | 96.0 | noncon | |
hsa-miR-4722-3p | 439-445 | -0.26 | 96.0 | -0.01 | 37.0 | noncon | |
hsa-miR-7151-3p | 275-282 | -0.258 | 95.0 | -0.01 | 59.0 | noncon | |
hsa-miR-1224-3p | 145-151 | -0.257 | 95.0 | -0.257 | 97.0 | noncon | |
hsa-miR-6841-3p | 37-43 | -0.256 | 91.0 | -0.256 | 94.0 | noncon | |
hsa-miR-4721 | 594-600 | -0.254 | 91.0 | -0.01 | 29.0 | noncon | |
hsa-miR-141-3p | 517-524 | -0.253 | 96.0 | -0.01 | 53.0 | noncon |