GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT13



General Information
Gene Symbol:   
GALNT13
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 13
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Golgi enzyme that initiated O-GalNAc modification at Ser/Thr

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8IUC8 
NCBI GeneID:   
114805
GlyMap GeneID:   
114805
DNA aRefSeq:   
NM_001301627.1 
Protein RefSeq:   
NP_001288556.1 
BRENDA:   
Kinetic info.
OMIM number:   
608369
GeneCards database:   
GALNT13
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000409237 ENST00000431076 ENST00000494805 ZNF143
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4421 3434-3441 -0.614 99.0 -0.384 98.0 noncon
hsa-miR-5699-3p 3434-3441 -0.588 99.0 -0.369 98.0 noncon
hsa-miR-195-5p 3567-3574 -0.559 99.0 0.0 18.0 con
hsa-miR-16-5p 3567-3574 -0.559 99.0 0.0 18.0 con
hsa-miR-424-5p 3567-3574 -0.548 99.0 0.0 19.0 con
hsa-miR-6838-5p 3567-3574 -0.545 99.0 0.0 14.0 con
hsa-miR-15a-5p 3567-3574 -0.543 99.0 0.0 16.0 con
hsa-miR-6827-5p 3039-3046 -0.536 99.0 -0.357 96.0 noncon
hsa-miR-497-5p 3567-3574 -0.532 99.0 0.0 18.0 con
hsa-miR-15b-5p 3567-3574 -0.527 99.0 0.0 16.0 con
hsa-miR-3679-3p 213-220 -0.42 97.0 -0.42 98.0 noncon
hsa-miR-1291 608-615 -0.417 97.0 -0.327 96.0 noncon
hsa-miR-383-5p.1 332-339 -0.41 98.0 -0.41 98.0 noncon
hsa-miR-6775-3p 608-615 -0.403 97.0 -0.317 95.0 noncon
hsa-miR-6806-5p 80-87 -0.398 94.0 -0.398 96.0 noncon
hsa-miR-6511b-3p 2251-2258 -0.386 98.0 -0.261 95.0 noncon
hsa-miR-6511a-3p 2251-2258 -0.386 98.0 -0.261 95.0 noncon
hsa-miR-663b 610-617 -0.382 98.0 -0.301 97.0 noncon
hsa-miR-769-3p 110-117 -0.379 98.0 -0.379 99.0 noncon
hsa-miR-4524a-5p 3568-3574 -0.379 96.0 0.0 19.0 noncon
hsa-miR-450b-3p 110-117 -0.374 98.0 -0.374 99.0 noncon
hsa-miR-1244 367-374 -0.37 97.0 -0.37 98.0 noncon
hsa-miR-4524b-5p 3568-3574 -0.368 96.0 0.0 19.0 noncon
hsa-miR-7154-3p 161-168 -0.368 98.0 -0.368 98.0 noncon
hsa-miR-4253 3234-3241 -0.363 94.0 -0.246 90.0 noncon
hsa-miR-107 3566-3572 -0.358 97.0 0.0 16.0 con
hsa-miR-7111-3p 1476-1483 -0.35 98.0 -0.238 95.0 noncon
hsa-miR-3123 3319-3326 -0.347 99.0 -0.236 99.0 noncon
hsa-miR-103a-3p 3566-3572 -0.347 97.0 0.0 16.0 con
hsa-miR-200c-5p 3129-3136 -0.344 97.0 -0.234 95.0 noncon
hsa-miR-6862-5p 3234-3241 -0.342 93.0 -0.233 89.0 noncon
hsa-miR-218-5p 340-346 -0.34 97.0 -0.34 97.0 con
hsa-miR-6508-3p 1254-1261 -0.337 97.0 -0.229 95.0 noncon
hsa-miR-4751 1527-1534 -0.333 96.0 -0.227 92.0 noncon
hsa-miR-4293 1278-1285 -0.33 99.0 -0.225 97.0 noncon
hsa-miR-550a-3p 3129-3136 -0.323 97.0 -0.22 95.0 noncon
hsa-miR-124-3p.2 507-513 -0.323 92.0 -0.255 90.0 con
hsa-miR-6750-5p 2756-2763 -0.321 98.0 -0.219 97.0 noncon
hsa-miR-4470 1240-1247 -0.318 98.0 -0.217 96.0 noncon
hsa-miR-593-5p 77-83 -0.318 94.0 -0.318 95.0 noncon
hsa-miR-652-5p 445-452 -0.318 98.0 -0.251 98.0 noncon
hsa-miR-6822-5p 2756-2763 -0.313 98.0 -0.214 96.0 noncon
hsa-miR-331-3p 1178-1185 -0.311 97.0 -0.212 95.0 noncon
hsa-miR-4451 974-981 -0.309 93.0 -0.211 88.0 noncon
hsa-miR-7976 1836-1843 -0.309 98.0 -0.211 95.0 noncon
hsa-miR-767-5p 76-82 -0.307 97.0 -0.307 98.0 noncon
hsa-miR-545-3p 229-236 -0.305 98.0 -0.305 98.0 noncon
hsa-miR-4260 3226-3233 -0.305 95.0 -0.208 92.0 noncon
hsa-miR-4699-5p 517-524 -0.301 97.0 -0.238 97.0 noncon
hsa-miR-6734-5p 2005-2011 -0.298 93.0 -0.204 88.0 noncon
hsa-miR-3910 506-513 -0.295 98.0 -0.234 97.0 noncon
hsa-miR-8067 292-299 -0.284 98.0 -0.284 98.0 noncon
hsa-miR-4524a-5p 123-130 -0.282 92.0 -0.282 95.0 noncon
hsa-miR-4524b-5p 123-130 -0.282 92.0 -0.282 95.0 noncon
hsa-miR-519c-3p 1079-1086 -0.276 96.0 -0.189 94.0 noncon
hsa-miR-519b-3p 1079-1086 -0.276 96.0 -0.189 94.0 noncon
hsa-miR-519a-3p 1079-1086 -0.276 96.0 -0.189 94.0 noncon
hsa-miR-509-3p 2517-2523 -0.274 92.0 -0.188 89.0 noncon
hsa-miR-4661-3p 568-574 -0.272 93.0 -0.216 92.0 noncon
hsa-miR-130b-5p 490-497 -0.272 97.0 -0.216 97.0 noncon
hsa-miR-506-3p 507-513 -0.272 92.0 -0.216 90.0 con
hsa-miR-6740-3p 66-73 -0.27 94.0 -0.27 95.0 noncon
hsa-miR-6826-3p 815-822 -0.267 92.0 -0.212 91.0 noncon
hsa-miR-103b 1894-1901 -0.262 92.0 -0.18 90.0 noncon
hsa-miR-5584-5p 312-319 -0.261 97.0 -0.261 98.0 noncon
hsa-miR-6867-3p 1046-1053 -0.261 94.0 -0.179 92.0 noncon
hsa-miR-1229-3p 2252-2259 -0.256 94.0 -0.176 93.0 noncon
hsa-miR-30b-5p 2408-2415 -0.254 92.0 -0.175 87.0 noncon
hsa-miR-30c-5p 2408-2415 -0.254 92.0 -0.175 87.0 noncon
hsa-miR-30e-5p 2408-2415 -0.254 92.0 -0.175 87.0 noncon
hsa-miR-4471 2755-2761 -0.253 92.0 -0.174 88.0 noncon
hsa-miR-1303 3321-3328 -0.25 94.0 -0.172 92.0 noncon