GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
A3GALT2
A4GALT
A4GNT
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
AMDHD2
B3GALNT1
B3GALNT2
B3GALT1
B3GALT2
B3GALT4
B3GALT5
B3GALT6
B3GAT1
B3GAT2
B3GAT3
B3GLCT
B3GNT2
B3GNT3
B3GNT4
B3GNT5
B3GNT6
B3GNT7
B3GNT8
B4GALNT1
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
B4GALT6
B4GALT7
C1GALT1
C1GALT1C1
CALR
CANX
CEMIP2
CHPF
CHPF2
CHST1
CHST10
CHST11
CHST12
CHST13
CHST14
CHST15
CHST2
CHST3
CHST4
CHST5
CHST6
CHST7
CHST8
CHST9
CHSY1
CHSY3
CMAS
CSGALNACT1
CSGALNACT2
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
DPY19L1
DPY19L2
DPY19L3
DPY19L4
DSE
DSEL
EDEM1
EDEM2
EDEM3
ENGASE
EOGT
EXT1
EXT2
EXTL1
EXTL2
EXTL3
FAM20B
FCSK
FKRP
FKTN
FPGT
FUCA1
FUCA2
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
G6PC1
GAL3ST1
GAL3ST2
GAL3ST3
GAL3ST4
GALC
GALE
GALK1
GALK2
GALNS
GALNT1
GALNT10
GALNT11
GALNT12
GALNT13
GALNT14
GALNT15
GALNT16
GALNT17
GALNT18
GALNT2
GALNT3
GALNT4
GALNT5
GALNT6
GALNT7
GALNT8
GALNT9
GALNTL6
GALT
GANAB
GANC
GBA
GBGT1
GCK
GCNT1
GCNT2
GCNT3
GCNT4
GCNT7
GFPT1
GFPT2
GLA
TMEM2
GLB1
GLCE
GMDS
GMPPA
GMPPB
GNE
GNPDA1
GNPDA2
GNPNAT1
GNPTAB
GNPTG
GNS
GPAA1
GPI
GUSB
GXYLT1
GXYLT2
HAS1
HAS2
HAS3
HEXA
HEXB
HK1
HK2
HK3
HPSE
HGSNAT
HS2ST1
HS3ST1
HS3ST2
HS3ST3A1
HS3ST3B1
HS3ST4
HS3ST5
HS3ST6
HS6ST1
HS6ST2
HS6ST3
HYAL1
HYAL2
HYAL3
HYAL4
IDS
IDUA
LFNG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MANEAL
MFNG
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MGAT5B
MOGS
MPI
MPPE1
NAGA
NAGK
NAGLU
NAGPA
NANS
NDST1
NDST2
NDST3
NDST4
NEU1
NEU2
NEU3
NEU4
OGT
PAPSS1
PAPSS2
PGAP4
PGM1
PGM2
PGM3
PIGA
PIGB
PIGC
PIGF
PIGG
PIGH
PIGK
PIGL
PIGM
PIGN
PIGO
PIGP
PIGQ
PIGS
PIGT
PIGU
PIGV
PIGW
PIGX
PIGY
PMM1
PMM2
POFUT1
POFUT2
POGLUT1
POGLUT2
POGLUT3
POMGNT1
POMGNT2
POMT1
POMT2
PRKCSH
RENBP
RFNG
RPN1
RPN2
RXYLT1
SGSH
SLC2A1
SLC2A10
SLC2A12
SLC2A2
SLC2A3
SLC2A4
SLC2A5
SLC2A8
SLC35A1
SLC35A2
SLC35A3
SLC35B2
SLC35B3
SLC35B4
SLC35C1
SLC35D1
SLC35D2
ST3GAL1
ST3GAL2
ST3GAL3
ST3GAL4
ST3GAL5
ST3GAL6
ST6GAL1
ST6GAL2
ST6GALNAC1
ST6GALNAC2
ST6GALNAC3
ST6GALNAC4
ST6GALNAC5
ST6GALNAC6
ST8SIA1
ST8SIA2
ST8SIA3
ST8SIA4
ST8SIA5
ST8SIA6
STT3A
STT3B
SULF1
SULF2
TMTC1
TMTC2
TMTC3
TMTC4
TSTA3
UAP1
UGCG
UGDH
UGGT1
UGGT2
UGP2
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
UGT2A2
UGT2A3
UGT2B10
UGT2B11
UGT2B15
UGT2B17
UGT2B28
UGT2B4
UGT2B7
UGT3A1
UGT3A2
UGT8
UST
UXS1
XXYLT1
XYLT1
XYLT2
AGA
ARSK
ARSB
GAA
CMAHP
Pathway Map
TSTA3



General Information
Gene Symbol:   
TSTA3
Protein name:   
GDP-L-fucose synthase
Enzyme Class:   
CAZy Family:   
E.C. No:   
1.1.1.271
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

GDP-4-keto-6-deoxy-D-mannose → GDP-fucose
Reaction (IUBMB):   
No specified reaction.
About

• Synthesizes GDP-fucose GDP-4-keto-6-deoxy-D-mannose via an epimerization and reduction reaction which utilizes NADPH.
• Tissue-specific transplantation antigen (TSTA3) is a known cancer biomarker at the transcriptional level

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-6787639
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q13630 
NCBI GeneID:   
7264
GlyMap GeneID:   
7264
DNA aRefSeq:   
NM_001317783.1 
Protein RefSeq:   
NP_001304712.1 
BRENDA:   
Kinetic info.
OMIM number:   
137020
GeneCards database:   
TSTA3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GDP-4-keto-6-deoxy-D-mannose
Product:  
     GDP-fucose
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 60 50 40 30 20 10 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4751 167-174 -0.617 99.0 -0.617 99.0 noncon
hsa-miR-1343-5p 209-216 -0.565 99.0 -0.565 99.0 noncon
hsa-miR-4763-3p 69-76 -0.564 99.0 -0.564 99.0 noncon
hsa-miR-491-5p 211-218 -0.562 99.0 -0.562 99.0 noncon
hsa-miR-1207-5p 69-76 -0.546 99.0 -0.546 99.0 noncon
hsa-miR-939-5p 209-216 -0.533 99.0 -0.533 99.0 noncon
hsa-miR-125b-5p 171-178 -0.493 99.0 -0.493 99.0 con
hsa-miR-1915-3p 260-267 -0.486 99.0 -0.353 99.0 noncon
hsa-miR-4319 171-178 -0.485 99.0 -0.485 99.0 con
hsa-miR-125a-5p 171-178 -0.469 98.0 -0.469 99.0 con
hsa-miR-6811-3p 286-292 -0.468 99.0 -0.086 78.0 noncon
hsa-miR-185-3p 127-134 -0.467 97.0 -0.467 98.0 noncon
hsa-miR-6764-5p 260-267 -0.465 99.0 -0.338 99.0 noncon
hsa-miR-6805-5p 222-228 -0.442 98.0 -0.442 98.0 noncon
hsa-miR-8073 72-79 -0.43 99.0 -0.43 99.0 noncon
hsa-miR-221-5p 72-79 -0.43 99.0 -0.43 99.0 noncon
hsa-miR-3939 228-234 -0.405 92.0 -0.405 94.0 noncon
hsa-miR-6846-5p 221-227 -0.398 95.0 -0.398 96.0 noncon
hsa-miR-3194-5p 36-43 -0.393 98.0 -0.393 98.0 noncon
hsa-miR-6848-5p 221-227 -0.387 94.0 -0.387 95.0 noncon
hsa-miR-1293 89-96 -0.375 98.0 -0.375 98.0 noncon
hsa-miR-6736-3p 77-84 -0.359 98.0 -0.359 98.0 noncon
hsa-miR-296-5p 149-155 -0.359 94.0 -0.359 95.0 noncon
hsa-miR-759 238-245 -0.339 99.0 -0.249 98.0 noncon
hsa-miR-6796-5p 212-218 -0.338 95.0 -0.338 96.0 noncon
hsa-miR-4745-5p 254-260 -0.328 95.0 -0.242 91.0 noncon
hsa-miR-4325 275-281 -0.319 97.0 -0.235 96.0 noncon
hsa-miR-4498 219-225 -0.306 93.0 -0.306 94.0 noncon
hsa-miR-4654 252-258 -0.305 97.0 -0.225 95.0 noncon
hsa-miR-6722-3p 224-230 -0.304 94.0 -0.304 95.0 noncon
hsa-miR-4758-3p 147-153 -0.304 95.0 -0.304 97.0 noncon
hsa-miR-5589-5p 92-99 -0.299 99.0 -0.299 99.0 noncon
hsa-miR-6728-5p 251-257 -0.292 97.0 -0.216 95.0 noncon
hsa-miR-4483 89-96 -0.291 98.0 -0.291 98.0 noncon
hsa-miR-4697-5p 152-158 -0.29 92.0 -0.29 93.0 noncon
hsa-miR-5001-5p 219-225 -0.285 92.0 -0.285 93.0 noncon
hsa-miR-6829-5p 126-132 -0.283 94.0 -0.283 96.0 noncon
hsa-miR-873-5p.2 246-252 -0.281 97.0 -0.208 94.0 noncon
hsa-miR-6798-5p 223-229 -0.281 94.0 -0.281 96.0 noncon
hsa-miR-6511b-5p 106-112 -0.279 95.0 -0.279 96.0 noncon
hsa-miR-563 64-70 -0.278 93.0 -0.278 95.0 noncon
hsa-miR-380-5p 64-70 -0.277 93.0 -0.277 95.0 noncon
hsa-miR-6811-5p 106-112 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-5187-5p 251-257 -0.271 93.0 -0.201 90.0 noncon
hsa-miR-1909-3p 224-230 -0.268 92.0 -0.268 94.0 noncon
hsa-miR-762 219-225 -0.266 94.0 -0.266 95.0 noncon
hsa-miR-4481 254-260 -0.266 94.0 -0.197 91.0 noncon
hsa-miR-4270 258-264 -0.26 95.0 -0.193 92.0 noncon
hsa-miR-4260 129-135 -0.256 93.0 -0.256 95.0 noncon
hsa-miR-1286 246-252 -0.25 95.0 -0.185 94.0 noncon