GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
A3GALT2
A4GALT
A4GNT
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
AMDHD2
B3GALNT1
B3GALNT2
B3GALT1
B3GALT2
B3GALT4
B3GALT5
B3GALT6
B3GAT1
B3GAT2
B3GAT3
B3GLCT
B3GNT2
B3GNT3
B3GNT4
B3GNT5
B3GNT6
B3GNT7
B3GNT8
B4GALNT1
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
B4GALT6
B4GALT7
C1GALT1
C1GALT1C1
CALR
CANX
CEMIP2
CHPF
CHPF2
CHST1
CHST10
CHST11
CHST12
CHST13
CHST14
CHST15
CHST2
CHST3
CHST4
CHST5
CHST6
CHST7
CHST8
CHST9
CHSY1
CHSY3
CMAS
CSGALNACT1
CSGALNACT2
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
DPY19L1
DPY19L2
DPY19L3
DPY19L4
DSE
DSEL
EDEM1
EDEM2
EDEM3
ENGASE
EOGT
EXT1
EXT2
EXTL1
EXTL2
EXTL3
FAM20B
FCSK
FKRP
FKTN
FPGT
FUCA1
FUCA2
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
G6PC1
GAL3ST1
GAL3ST2
GAL3ST3
GAL3ST4
GALC
GALE
GALK1
GALK2
GALNS
GALNT1
GALNT10
GALNT11
GALNT12
GALNT13
GALNT14
GALNT15
GALNT16
GALNT17
GALNT18
GALNT2
GALNT3
GALNT4
GALNT5
GALNT6
GALNT7
GALNT8
GALNT9
GALNTL6
GALT
GANAB
GANC
GBA
GBGT1
GCK
GCNT1
GCNT2
GCNT3
GCNT4
GCNT7
GFPT1
GFPT2
GLA
TMEM2
GLB1
GLCE
GMDS
GMPPA
GMPPB
GNE
GNPDA1
GNPDA2
GNPNAT1
GNPTAB
GNPTG
GNS
GPAA1
GPI
GUSB
GXYLT1
GXYLT2
HAS1
HAS2
HAS3
HEXA
HEXB
HK1
HK2
HK3
HPSE
HGSNAT
HS2ST1
HS3ST1
HS3ST2
HS3ST3A1
HS3ST3B1
HS3ST4
HS3ST5
HS3ST6
HS6ST1
HS6ST2
HS6ST3
HYAL1
HYAL2
HYAL3
HYAL4
IDS
IDUA
LFNG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MANEAL
MFNG
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MGAT5B
MOGS
MPI
MPPE1
NAGA
NAGK
NAGLU
NAGPA
NANS
NDST1
NDST2
NDST3
NDST4
NEU1
NEU2
NEU3
NEU4
OGT
PAPSS1
PAPSS2
PGAP4
PGM1
PGM2
PGM3
PIGA
PIGB
PIGC
PIGF
PIGG
PIGH
PIGK
PIGL
PIGM
PIGN
PIGO
PIGP
PIGQ
PIGS
PIGT
PIGU
PIGV
PIGW
PIGX
PIGY
PMM1
PMM2
POFUT1
POFUT2
POGLUT1
POGLUT2
POGLUT3
POMGNT1
POMGNT2
POMT1
POMT2
PRKCSH
RENBP
RFNG
RPN1
RPN2
RXYLT1
SGSH
SLC2A1
SLC2A10
SLC2A12
SLC2A2
SLC2A3
SLC2A4
SLC2A5
SLC2A8
SLC35A1
SLC35A2
SLC35A3
SLC35B2
SLC35B3
SLC35B4
SLC35C1
SLC35D1
SLC35D2
ST3GAL1
ST3GAL2
ST3GAL3
ST3GAL4
ST3GAL5
ST3GAL6
ST6GAL1
ST6GAL2
ST6GALNAC1
ST6GALNAC2
ST6GALNAC3
ST6GALNAC4
ST6GALNAC5
ST6GALNAC6
ST8SIA1
ST8SIA2
ST8SIA3
ST8SIA4
ST8SIA5
ST8SIA6
STT3A
STT3B
SULF1
SULF2
TMTC1
TMTC2
TMTC3
TMTC4
TSTA3
UAP1
UGCG
UGDH
UGGT1
UGGT2
UGP2
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
UGT2A2
UGT2A3
UGT2B10
UGT2B11
UGT2B15
UGT2B17
UGT2B28
UGT2B4
UGT2B7
UGT3A1
UGT3A2
UGT8
UST
UXS1
XXYLT1
XYLT1
XYLT2
AGA
ARSK
ARSB
GAA
CMAHP
Pathway Map
SLC35B2



General Information
Gene Symbol:   
SLC35B2
Protein name:   
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

PAPS [Cyto] → PAPS [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• SLC35B2 and B3 transfer PAPS from the cytosol into the Golgi apparatus from the cytoplasm.
• PAPS is a universal sulfuryl donor for sulfation.
• Depending on cancer type, the expression of PAPST1 and PAPST2 can increase or decrease, resulting in increases or decreases in sulfation of GAGs, respectively.
• Decreased expression of PAPST1 and PAPST2 caused FGF signaling to decrease in colorectal cells.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-174362
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8TB61 
NCBI GeneID:   
347734
GlyMap GeneID:   
347734
DNA aRefSeq:   
NM_001286509.1 
Protein RefSeq:   
NP_001273438.1 
BRENDA:   
Kinetic info.
OMIM number:   
610788
GeneCards database:   
SLC35B2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     PAPS [Cyto]
Product:  
     PAPS [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-744-5p 340-347 -0.703 99.0 -0.703 99.0 noncon
hsa-miR-365a-3p 1493-1500 -0.651 99.0 0.0 31.0 noncon
hsa-miR-365b-3p 1493-1500 -0.651 99.0 0.0 31.0 noncon
hsa-miR-25-5p 677-684 -0.598 99.0 -0.595 99.0 noncon
hsa-miR-5682 25-32 -0.566 99.0 -0.566 99.0 noncon
hsa-miR-1273g-3p 1457-1464 -0.553 99.0 -0.001 39.0 noncon
hsa-miR-593-5p 152-159 -0.543 99.0 -0.543 99.0 noncon
hsa-miR-939-5p 348-355 -0.517 99.0 -0.517 99.0 noncon
hsa-miR-6804-5p 289-296 -0.507 98.0 -0.507 99.0 noncon
hsa-miR-29c-3p 24-31 -0.497 98.0 -0.497 99.0 noncon
hsa-miR-29b-3p 24-31 -0.497 98.0 -0.497 99.0 noncon
hsa-miR-29a-3p 24-31 -0.497 98.0 -0.497 99.0 noncon
hsa-miR-6802-3p 877-884 -0.481 99.0 -0.479 99.0 noncon
hsa-miR-665 1353-1360 -0.479 99.0 -0.477 99.0 noncon
hsa-miR-3678-3p 77-84 -0.471 99.0 -0.471 99.0 noncon
hsa-miR-7854-3p 411-418 -0.47 99.0 -0.47 99.0 noncon
hsa-miR-6766-5p 188-195 -0.457 98.0 -0.457 98.0 noncon
hsa-miR-2467-3p 1209-1216 -0.456 99.0 -0.454 99.0 noncon
hsa-miR-6866-5p 209-216 -0.456 98.0 -0.456 98.0 noncon
hsa-miR-6756-5p 188-195 -0.454 98.0 -0.454 98.0 noncon
hsa-miR-1343-5p 348-355 -0.453 99.0 -0.453 99.0 noncon
hsa-miR-6883-5p 896-903 -0.439 99.0 -0.437 99.0 noncon
hsa-miR-6801-3p 990-997 -0.439 98.0 -0.437 98.0 noncon
hsa-miR-4733-3p 1235-1242 -0.435 98.0 -0.433 99.0 noncon
hsa-miR-1229-3p 1238-1245 -0.425 98.0 -0.423 98.0 noncon
hsa-miR-4505 352-359 -0.422 98.0 -0.422 99.0 noncon
hsa-miR-124-3p.2 1028-1035 -0.416 97.0 -0.414 98.0 con
hsa-miR-548av-3p 1055-1062 -0.415 99.0 -0.413 99.0 noncon
hsa-miR-6753-3p 974-981 -0.408 97.0 -0.406 98.0 noncon
hsa-miR-7107-3p 974-981 -0.408 97.0 -0.406 98.0 noncon
hsa-miR-4520-3p 131-138 -0.408 99.0 -0.408 99.0 noncon
hsa-miR-149-3p 896-903 -0.407 98.0 -0.405 98.0 noncon
hsa-miR-4728-5p 896-903 -0.405 98.0 -0.403 99.0 noncon
hsa-miR-6785-5p 896-903 -0.405 98.0 -0.403 99.0 noncon
hsa-miR-324-5p 1315-1322 -0.405 96.0 -0.403 97.0 noncon
hsa-miR-4693-3p 363-370 -0.401 98.0 -0.401 98.0 noncon
hsa-miR-3678-3p 1210-1217 -0.4 99.0 -0.398 99.0 noncon
hsa-miR-6810-3p 990-997 -0.397 97.0 -0.395 98.0 noncon
hsa-miR-6892-5p 1159-1166 -0.396 98.0 -0.394 99.0 noncon
hsa-miR-4722-3p 422-429 -0.395 99.0 -0.395 99.0 noncon
hsa-miR-6865-3p 1284-1291 -0.392 98.0 -0.39 98.0 noncon
hsa-miR-5192 589-596 -0.384 99.0 -0.382 99.0 noncon
hsa-miR-3130-3p 457-464 -0.383 99.0 -0.381 99.0 noncon
hsa-miR-6511b-3p 1237-1244 -0.379 97.0 -0.377 98.0 noncon
hsa-miR-6727-3p 422-429 -0.377 99.0 -0.377 99.0 noncon
hsa-miR-5787 352-359 -0.376 99.0 -0.376 99.0 noncon
hsa-miR-4713-3p 1358-1364 -0.373 94.0 -0.371 95.0 noncon
hsa-miR-7160-3p 525-532 -0.372 97.0 -0.37 98.0 noncon
hsa-miR-6511a-3p 1237-1244 -0.371 97.0 -0.369 98.0 noncon
hsa-miR-4327 80-87 -0.371 98.0 -0.371 98.0 noncon
hsa-miR-218-5p 1246-1253 -0.371 97.0 -0.369 98.0 con
hsa-miR-6822-5p 1157-1163 -0.363 99.0 -0.361 99.0 noncon
hsa-miR-624-5p 1397-1403 -0.356 96.0 -0.354 97.0 noncon
hsa-miR-412-3p 1287-1294 -0.356 98.0 -0.354 98.0 noncon
hsa-miR-4471 1156-1162 -0.353 96.0 -0.351 97.0 noncon
hsa-miR-6750-5p 1157-1163 -0.352 99.0 -0.35 99.0 noncon
hsa-miR-4257 922-929 -0.351 99.0 -0.349 99.0 noncon
hsa-miR-6510-5p 582-589 -0.347 98.0 -0.345 98.0 noncon
hsa-miR-6754-3p 1287-1294 -0.346 98.0 -0.344 98.0 noncon
hsa-miR-4435 200-207 -0.345 97.0 -0.345 98.0 noncon
hsa-miR-1911-5p 114-120 -0.344 95.0 -0.344 96.0 noncon
hsa-miR-6815-5p 1188-1194 -0.343 97.0 -0.341 98.0 noncon
hsa-miR-6865-5p 1188-1194 -0.343 97.0 -0.341 98.0 noncon
hsa-miR-506-3p 1028-1035 -0.34 96.0 -0.338 97.0 con
hsa-miR-6763-3p 812-818 -0.339 92.0 -0.337 94.0 noncon
hsa-miR-6721-5p 1327-1334 -0.337 96.0 -0.335 97.0 noncon
hsa-miR-6784-5p 88-94 -0.337 93.0 -0.337 94.0 noncon
hsa-miR-6753-5p 1234-1240 -0.334 97.0 -0.332 98.0 noncon
hsa-miR-6840-5p 1072-1078 -0.328 91.0 -0.326 93.0 noncon
hsa-miR-6797-3p 227-233 -0.326 97.0 -0.326 98.0 noncon
hsa-miR-7152-3p 332-339 -0.324 96.0 -0.324 97.0 noncon
hsa-miR-6076 227-233 -0.316 96.0 -0.316 97.0 noncon
hsa-miR-6780b-5p 184-191 -0.315 95.0 -0.315 96.0 noncon
hsa-miR-6829-5p 85-91 -0.312 96.0 -0.312 97.0 noncon
hsa-miR-4679 971-978 -0.303 98.0 -0.302 98.0 noncon
hsa-miR-938 1491-1497 -0.302 97.0 0.0 11.0 noncon
hsa-miR-6865-3p 858-864 -0.3 96.0 -0.299 97.0 noncon
hsa-miR-6846-3p 1113-1119 -0.298 94.0 -0.297 96.0 noncon
hsa-miR-939-3p 1005-1012 -0.295 96.0 -0.294 97.0 noncon
hsa-miR-6851-3p 867-873 -0.293 95.0 -0.292 97.0 noncon
hsa-miR-4725-3p 184-191 -0.291 94.0 -0.291 95.0 noncon
hsa-miR-548k 1399-1406 -0.29 98.0 -0.289 99.0 noncon
hsa-miR-6509-3p 1458-1464 -0.289 96.0 -0.001 25.0 noncon
hsa-miR-4266 1344-1350 -0.288 93.0 -0.287 95.0 noncon
hsa-miR-509-3-5p 1455-1461 -0.286 98.0 -0.001 47.0 noncon
hsa-miR-4734 342-348 -0.286 91.0 -0.286 93.0 noncon
hsa-miR-3065-3p 1296-1302 -0.285 96.0 -0.284 97.0 noncon
hsa-miR-3157-5p 936-943 -0.285 96.0 -0.284 97.0 noncon
hsa-miR-6791-3p 1009-1016 -0.285 97.0 -0.284 98.0 noncon
hsa-miR-4283 1067-1073 -0.284 92.0 -0.283 94.0 noncon
hsa-miR-6858-3p 934-940 -0.283 97.0 -0.282 98.0 noncon
hsa-miR-6893-5p 705-711 -0.282 98.0 -0.281 98.0 noncon
hsa-miR-6808-5p 705-711 -0.282 98.0 -0.281 98.0 noncon
hsa-miR-4519 510-517 -0.282 96.0 -0.281 97.0 noncon
hsa-miR-3157-3p 944-950 -0.282 97.0 -0.281 97.0 noncon
hsa-miR-6836-5p 581-587 -0.281 94.0 -0.28 95.0 noncon
hsa-miR-658 676-682 -0.281 90.0 -0.28 92.0 noncon
hsa-miR-509-5p 1455-1461 -0.275 98.0 -0.001 47.0 noncon
hsa-miR-4470 436-442 -0.275 97.0 -0.275 98.0 noncon
hsa-miR-548av-5p 1399-1406 -0.274 98.0 -0.273 99.0 noncon
hsa-miR-3972 43-49 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-6851-5p 1342-1348 -0.272 92.0 -0.271 94.0 noncon
hsa-miR-3691-3p 1463-1469 -0.271 96.0 -0.001 42.0 noncon
hsa-miR-4696 1167-1173 -0.269 96.0 -0.268 97.0 noncon
hsa-miR-8059 1156-1162 -0.269 95.0 -0.268 97.0 noncon
hsa-miR-1262 1037-1043 -0.267 95.0 -0.266 96.0 noncon
hsa-miR-3913-3p 448-454 -0.266 93.0 -0.266 95.0 noncon
hsa-miR-17-3p 1454-1460 -0.265 97.0 -0.001 38.0 noncon
hsa-miR-1827 490-496 -0.264 94.0 -0.263 95.0 noncon
hsa-miR-2467-3p 77-83 -0.263 95.0 -0.263 96.0 noncon
hsa-miR-6132 581-587 -0.263 92.0 -0.262 94.0 noncon
hsa-miR-489-3p 448-454 -0.262 98.0 -0.262 98.0 noncon
hsa-miR-6829-3p 1009-1016 -0.261 96.0 -0.26 97.0 noncon
hsa-miR-4733-3p 22-28 -0.261 95.0 -0.261 97.0 noncon
hsa-miR-1271-5p 154-160 -0.258 93.0 -0.258 95.0 noncon
hsa-miR-4701-3p 1037-1043 -0.256 95.0 -0.255 96.0 noncon
hsa-miR-7974 284-290 -0.256 90.0 -0.256 93.0 noncon
hsa-miR-644a 720-726 -0.256 92.0 -0.255 95.0 noncon
hsa-miR-3148 1512-1519 -0.254 99.0 0.0 26.0 noncon
hsa-miR-6729-3p 1314-1320 -0.253 92.0 -0.252 94.0 noncon
hsa-miR-585-5p 26-32 -0.253 90.0 -0.253 93.0 noncon
hsa-miR-6736-5p 1037-1043 -0.252 94.0 -0.251 96.0 noncon
hsa-miR-3189-5p 96-103 -0.251 95.0 -0.251 97.0 noncon
hsa-miR-6846-3p 473-479 -0.25 92.0 -0.249 94.0 noncon
hsa-miR-4722-3p 384-390 -0.25 95.0 -0.25 96.0 noncon