GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Glycogene class
A3GALT2
A4GALT
A4GNT
ABO
ALG1
ALG10
ALG10B
ALG11
ALG12
ALG13
ALG14
ALG1L
ALG1L2
ALG2
ALG3
ALG5
ALG6
ALG8
ALG9
AMDHD2
B3GALNT1
B3GALNT2
B3GALT1
B3GALT2
B3GALT4
B3GALT5
B3GALT6
B3GAT1
B3GAT2
B3GAT3
B3GLCT
B3GNT2
B3GNT3
B3GNT4
B3GNT5
B3GNT6
B3GNT7
B3GNT8
B4GALNT1
B4GALNT2
B4GALNT3
B4GALNT4
B4GALT1
B4GALT2
B4GALT3
B4GALT4
B4GALT5
B4GALT6
B4GALT7
C1GALT1
C1GALT1C1
CALR
CANX
CEMIP2
CHPF
CHPF2
CHST1
CHST10
CHST11
CHST12
CHST13
CHST14
CHST15
CHST2
CHST3
CHST4
CHST5
CHST6
CHST7
CHST8
CHST9
CHSY1
CHSY3
CMAS
CSGALNACT1
CSGALNACT2
CTBS
DAD1
DDOST
DPAGT1
DPM1
DPM2
DPM3
DPY19L1
DPY19L2
DPY19L3
DPY19L4
DSE
DSEL
EDEM1
EDEM2
EDEM3
ENGASE
EOGT
EXT1
EXT2
EXTL1
EXTL2
EXTL3
FAM20B
FCSK
FKRP
FKTN
FPGT
FUCA1
FUCA2
FUT1
FUT10
FUT11
FUT2
FUT3
FUT4
FUT5
FUT6
FUT7
FUT8
FUT9
G6PC1
GAL3ST1
GAL3ST2
GAL3ST3
GAL3ST4
GALC
GALE
GALK1
GALK2
GALNS
GALNT1
GALNT10
GALNT11
GALNT12
GALNT13
GALNT14
GALNT15
GALNT16
GALNT17
GALNT18
GALNT2
GALNT3
GALNT4
GALNT5
GALNT6
GALNT7
GALNT8
GALNT9
GALNTL6
GALT
GANAB
GANC
GBA
GBGT1
GCK
GCNT1
GCNT2
GCNT3
GCNT4
GCNT7
GFPT1
GFPT2
GLA
TMEM2
GLB1
GLCE
GMDS
GMPPA
GMPPB
GNE
GNPDA1
GNPDA2
GNPNAT1
GNPTAB
GNPTG
GNS
GPAA1
GPI
GUSB
GXYLT1
GXYLT2
HAS1
HAS2
HAS3
HEXA
HEXB
HK1
HK2
HK3
HPSE
HGSNAT
HS2ST1
HS3ST1
HS3ST2
HS3ST3A1
HS3ST3B1
HS3ST4
HS3ST5
HS3ST6
HS6ST1
HS6ST2
HS6ST3
HYAL1
HYAL2
HYAL3
HYAL4
IDS
IDUA
LFNG
MAN1A1
MAN1A2
MAN1B1
MAN1C1
MAN2A1
MAN2A2
MAN2B1
MAN2B2
MAN2C1
MANBA
MANEA
MANEAL
MFNG
MGAT1
MGAT2
MGAT3
MGAT4A
MGAT4B
MGAT4C
MGAT4D
MGAT5
MGAT5B
MOGS
MPI
MPPE1
NAGA
NAGK
NAGLU
NAGPA
NANS
NDST1
NDST2
NDST3
NDST4
NEU1
NEU2
NEU3
NEU4
OGT
PAPSS1
PAPSS2
PGAP4
PGM1
PGM2
PGM3
PIGA
PIGB
PIGC
PIGF
PIGG
PIGH
PIGK
PIGL
PIGM
PIGN
PIGO
PIGP
PIGQ
PIGS
PIGT
PIGU
PIGV
PIGW
PIGX
PIGY
PMM1
PMM2
POFUT1
POFUT2
POGLUT1
POGLUT2
POGLUT3
POMGNT1
POMGNT2
POMT1
POMT2
PRKCSH
RENBP
RFNG
RPN1
RPN2
RXYLT1
SGSH
SLC2A1
SLC2A10
SLC2A12
SLC2A2
SLC2A3
SLC2A4
SLC2A5
SLC2A8
SLC35A1
SLC35A2
SLC35A3
SLC35B2
SLC35B3
SLC35B4
SLC35C1
SLC35D1
SLC35D2
ST3GAL1
ST3GAL2
ST3GAL3
ST3GAL4
ST3GAL5
ST3GAL6
ST6GAL1
ST6GAL2
ST6GALNAC1
ST6GALNAC2
ST6GALNAC3
ST6GALNAC4
ST6GALNAC5
ST6GALNAC6
ST8SIA1
ST8SIA2
ST8SIA3
ST8SIA4
ST8SIA5
ST8SIA6
STT3A
STT3B
SULF1
SULF2
TMTC1
TMTC2
TMTC3
TMTC4
TSTA3
UAP1
UGCG
UGDH
UGGT1
UGGT2
UGP2
UGT1A1
UGT1A10
UGT1A3
UGT1A4
UGT1A5
UGT1A6
UGT1A7
UGT1A8
UGT1A9
UGT2A1
UGT2A2
UGT2A3
UGT2B10
UGT2B11
UGT2B15
UGT2B17
UGT2B28
UGT2B4
UGT2B7
UGT3A1
UGT3A2
UGT8
UST
UXS1
XXYLT1
XYLT1
XYLT2
AGA
ARSK
ARSB
GAA
CMAHP
Pathway Map
HYAL3



General Information
Gene Symbol:   
HYAL3
Protein name:   
Hyaluronidase-3
Enzyme Class:   
Glycosidase
CAZy Family:   
GH56
E.C. No:   
3.2.1.35
Organs:   
Reaction (SNFG):   
HYAL3
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Hyaluronanidases cleave glycosidic β1-4 linkages between glucuronic acid and N-acetylglucosamine residues in the hyaluronan polymer.
• Evidence is mixed as to the role hyaluronanidases play in the context of promoting cancer. HYAL protein expression has been correlated to cancer survival and disease progression for various cancer types, such as bladder and pancreatic.
• HYAL3 does not have significant hyaluronidase activity.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2024101
Related Database
Organism:   
Homo sapiens
Uniprot:   
O43820 
NCBI GeneID:   
8372
GlyMap GeneID:   
8372
DNA aRefSeq:   
NM_001200029.1 
Protein RefSeq:   
NP_001186958.1 
BRENDA:   
Kinetic info.
OMIM number:   
604038
GeneCards database:   
HYAL3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GlcNAc(b1-4)GlcA(b1-3)
Product:  
     GlcA(b1-3)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3177-3p 313-320 -0.592 98.0 -0.592 98.0 noncon
hsa-miR-6883-5p 100-107 -0.551 99.0 -0.551 99.0 noncon
hsa-miR-149-3p 100-107 -0.535 99.0 -0.535 99.0 noncon
hsa-miR-6785-5p 100-107 -0.517 99.0 -0.517 99.0 noncon
hsa-miR-4728-5p 100-107 -0.501 99.0 -0.501 99.0 noncon
hsa-miR-943 92-99 -0.496 99.0 -0.496 99.0 noncon
hsa-miR-1227-5p 331-338 -0.49 99.0 -0.49 99.0 noncon
hsa-miR-3166 375-382 -0.468 98.0 -0.468 99.0 noncon
hsa-miR-7154-3p 199-206 -0.467 99.0 -0.467 99.0 noncon
hsa-miR-1915-5p 208-215 -0.46 98.0 -0.46 98.0 noncon
hsa-miR-4308 222-229 -0.46 99.0 -0.46 99.0 noncon
hsa-miR-4781-5p 116-122 -0.456 95.0 -0.456 96.0 noncon
hsa-miR-4260 332-339 -0.451 98.0 -0.451 98.0 noncon
hsa-miR-30b-3p 101-108 -0.446 99.0 -0.446 99.0 noncon
hsa-miR-1273h-5p 101-108 -0.438 98.0 -0.438 98.0 noncon
hsa-miR-3689b-3p 101-108 -0.43 98.0 -0.43 99.0 noncon
hsa-miR-3689a-3p 101-108 -0.43 98.0 -0.43 99.0 noncon
hsa-miR-3689c 101-108 -0.43 98.0 -0.43 99.0 noncon
hsa-miR-6779-5p 101-108 -0.43 98.0 -0.43 98.0 noncon
hsa-miR-4692 412-418 -0.429 99.0 0.0 29.0 noncon
hsa-miR-34a-5p 410-416 -0.423 97.0 0.0 12.0 noncon
hsa-miR-4514 412-418 -0.419 99.0 0.0 29.0 noncon
hsa-miR-6780a-5p 101-108 -0.417 98.0 -0.417 99.0 noncon
hsa-miR-6806-5p 273-280 -0.416 95.0 -0.416 96.0 noncon
hsa-miR-34c-5p 410-416 -0.413 96.0 0.0 11.0 noncon
hsa-miR-449a 410-416 -0.412 97.0 0.0 12.0 noncon
hsa-miR-3164 396-402 -0.406 98.0 -0.406 99.0 noncon
hsa-miR-449b-5p 410-416 -0.402 96.0 0.0 12.0 noncon
hsa-miR-4515 48-54 -0.394 97.0 -0.394 98.0 noncon
hsa-miR-1272 388-395 -0.39 99.0 -0.39 99.0 noncon
hsa-miR-4648 67-73 -0.387 98.0 -0.387 99.0 noncon
hsa-miR-7113-3p 224-231 -0.386 99.0 -0.386 99.0 noncon
hsa-miR-4695-3p 186-193 -0.384 98.0 -0.384 98.0 noncon
hsa-miR-380-5p 95-101 -0.377 97.0 -0.377 98.0 noncon
hsa-miR-27a-5p 287-294 -0.377 98.0 -0.377 98.0 noncon
hsa-miR-6820-3p 396-402 -0.373 98.0 -0.373 98.0 noncon
hsa-miR-6510-5p 32-38 -0.372 98.0 -0.372 99.0 noncon
hsa-miR-516b-3p 212-219 -0.36 97.0 -0.36 98.0 noncon
hsa-miR-516a-3p 212-219 -0.36 97.0 -0.36 98.0 noncon
hsa-miR-885-3p 36-42 -0.354 98.0 -0.354 99.0 noncon
hsa-miR-636 106-113 -0.353 98.0 -0.353 98.0 noncon
hsa-miR-921 282-289 -0.34 97.0 -0.34 98.0 noncon
hsa-miR-29b-1-5p 171-178 -0.336 98.0 -0.336 98.0 noncon
hsa-miR-7162-5p 212-219 -0.336 97.0 -0.336 98.0 noncon
hsa-miR-34b-5p 411-417 -0.335 99.0 0.0 0.0 noncon
hsa-miR-563 95-101 -0.334 95.0 -0.334 97.0 noncon
hsa-miR-5582-5p 271-278 -0.33 97.0 -0.33 98.0 noncon
hsa-miR-4745-5p 69-75 -0.328 95.0 -0.328 96.0 noncon
hsa-miR-4481 69-75 -0.321 97.0 -0.321 97.0 noncon
hsa-miR-4659a-5p 205-212 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-502-5p 209-216 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-6821-3p 298-305 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-6075 310-316 -0.317 91.0 -0.317 93.0 noncon
hsa-miR-449c-5p 411-417 -0.313 98.0 0.0 0.0 noncon
hsa-miR-34a-5p 16-22 -0.313 92.0 -0.313 94.0 noncon
hsa-miR-2682-5p 411-417 -0.31 98.0 0.0 0.0 noncon
hsa-miR-449b-5p 16-22 -0.303 91.0 -0.303 93.0 noncon
hsa-miR-449a 16-22 -0.302 91.0 -0.302 94.0 noncon
hsa-miR-6762-5p 331-337 -0.301 91.0 -0.301 93.0 noncon
hsa-miR-128-1-5p 331-337 -0.297 95.0 -0.297 96.0 noncon
hsa-miR-4659b-5p 205-212 -0.297 96.0 -0.297 97.0 noncon
hsa-miR-874-5p 149-155 -0.296 93.0 -0.296 94.0 noncon
hsa-miR-3148 404-411 -0.294 99.0 -0.294 99.0 noncon
hsa-miR-34c-5p 16-22 -0.292 90.0 -0.292 93.0 noncon
hsa-miR-1302 66-72 -0.288 95.0 -0.288 96.0 noncon
hsa-miR-214-3p 33-39 -0.281 97.0 -0.281 98.0 noncon
hsa-miR-4298 66-72 -0.274 94.0 -0.274 96.0 noncon
hsa-miR-1827 18-24 -0.273 94.0 -0.273 96.0 noncon
hsa-miR-7641 187-193 -0.267 96.0 -0.267 97.0 noncon
hsa-miR-3136-5p 93-99 -0.264 95.0 -0.264 96.0 noncon
hsa-miR-4423-3p 272-278 -0.263 93.0 -0.263 95.0 noncon
hsa-miR-3190-5p 151-157 -0.262 96.0 -0.262 97.0 noncon
hsa-miR-3169 49-55 -0.26 95.0 -0.26 96.0 noncon
hsa-miR-3619-5p 33-39 -0.258 97.0 -0.258 97.0 noncon
hsa-miR-6747-5p 113-119 -0.251 93.0 -0.251 95.0 noncon
hsa-miR-585-5p 363-369 -0.25 90.0 -0.25 93.0 noncon