Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• Forms T-antigen. In the absence of this, we are left with the Tn-antigen.
• Core-2 O-glycans are not formed in the absence of this enzyme, and in leukocytes this results in reduced cell adhesion.
• Absence of T-antigen promotes metastasis in a number of models including pancreatic cancer.
• Tn-syndrome is a rare hematological disorder characterized by the expression of the Tn-antigen on a subpopulation of blood cells in all lineages.
• Active T-synthase in vertebrates, including humans, requires a specific molecular chaperone Cosmc (Core-1 β3galactosyltransferase Specific Molecular Chaperone) or C1GALT1C1 (Core-1 β3Galactosyltransferase Chaperone-1) for its folding in vivo.
• T-synthase is localized in Golgi apparatus, Cosmc mainly resides in the endoplasmic reticulum (ER).
• Knocking out C1GalT1 activity in mice results in severe hematological disorders.