GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT5



General Information
Gene Symbol:   
GALNT5
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 5
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Localized in Golgi where it catalyzes O-GalNAc glycosylation.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q7Z7M9 
NCBI GeneID:   
11227
GlyMap GeneID:   
11227
DNA aRefSeq:   
NM_001329868.1 
Protein RefSeq:   
NP_001316797.1 
BRENDA:   
Kinetic info.
OMIM number:   
615129
GeneCards database:   
GALNT5
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000259056 ERG USF1 GMEB1 EHF LYL1 MAZ BHLHE40 ATF2 MAFK HOXA4 TP53 E2F1 NR4A1 MNT MAX ZNF83 HOXA5 NKX2-1 IRF1 PRDM6 PRDM6 TAL1 ZNF692 REST
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4506 28-35 -0.572 99.0 -0.572 99.0 noncon
hsa-miR-3181 1420-1427 -0.513 96.0 -0.097 58.0 noncon
hsa-miR-27b-3p 39-46 -0.507 99.0 -0.506 99.0 con
hsa-miR-27a-3p 39-46 -0.507 99.0 -0.506 99.0 con
hsa-miR-6509-3p 618-625 -0.419 98.0 -0.253 96.0 noncon
hsa-miR-4726-5p 363-370 -0.401 96.0 -0.249 90.0 noncon
hsa-miR-4640-5p 363-370 -0.399 96.0 -0.248 90.0 noncon
hsa-miR-629-5p 25-32 -0.395 99.0 -0.395 99.0 noncon
hsa-miR-634 551-558 -0.394 98.0 -0.244 96.0 noncon
hsa-miR-4671-5p 197-204 -0.387 95.0 -0.24 87.0 noncon
hsa-miR-4493 649-656 -0.365 97.0 -0.222 93.0 noncon
hsa-miR-1287-3p 454-461 -0.358 95.0 -0.223 92.0 noncon
hsa-miR-6866-5p 1214-1221 -0.35 95.0 -0.069 75.0 noncon
hsa-miR-8070 132-139 -0.347 98.0 -0.217 96.0 noncon
hsa-miR-1269a 172-179 -0.345 97.0 -0.215 92.0 noncon
hsa-miR-1269b 172-179 -0.345 97.0 -0.215 92.0 noncon
hsa-miR-4265 366-373 -0.334 96.0 -0.209 92.0 noncon
hsa-miR-7113-5p 2830-2837 -0.332 97.0 -0.003 26.0 noncon
hsa-miR-4296 366-373 -0.331 96.0 -0.207 92.0 noncon
hsa-miR-1200 162-169 -0.33 98.0 -0.206 95.0 noncon
hsa-miR-4322 366-373 -0.326 96.0 -0.204 93.0 noncon
hsa-miR-6505-3p 2302-2309 -0.322 96.0 -0.064 72.0 noncon
hsa-miR-4747-3p 2619-2625 -0.319 98.0 -0.036 49.0 noncon
hsa-miR-3189-5p 2128-2135 -0.319 97.0 -0.064 75.0 noncon
hsa-miR-3653-5p 2696-2703 -0.319 99.0 -0.036 77.0 noncon
hsa-miR-181a-2-3p 617-624 -0.317 98.0 -0.194 95.0 noncon
hsa-miR-31-3p 2676-2682 -0.299 94.0 -0.034 65.0 noncon
hsa-miR-4317 774-781 -0.29 95.0 -0.059 74.0 noncon
hsa-miR-203a-5p 1800-1807 -0.288 94.0 -0.058 69.0 noncon
hsa-miR-4255 680-687 -0.284 97.0 -0.175 94.0 noncon
hsa-miR-299-5p 24-30 -0.281 96.0 -0.281 97.0 noncon
hsa-miR-1288-3p 2408-2414 -0.28 93.0 -0.046 68.0 noncon
hsa-miR-6797-5p 497-504 -0.279 94.0 -0.176 86.0 noncon
hsa-miR-3137 2818-2825 -0.278 96.0 -0.003 47.0 noncon
hsa-miR-4720-3p 2671-2678 -0.274 97.0 -0.031 63.0 noncon
hsa-miR-4532 2256-2262 -0.274 91.0 -0.056 58.0 noncon
hsa-miR-216a-3p 39-45 -0.272 97.0 -0.271 97.0 con
hsa-miR-1249-5p 497-504 -0.271 94.0 -0.171 86.0 noncon
hsa-miR-661 1341-1348 -0.27 95.0 -0.055 69.0 noncon
hsa-miR-502-5p 2586-2593 -0.268 95.0 -0.031 70.0 noncon
hsa-miR-3127-3p 1102-1109 -0.262 92.0 -0.053 69.0 noncon
hsa-miR-3681-3p 39-45 -0.261 96.0 -0.261 97.0 con
hsa-miR-492 2769-2775 -0.259 90.0 -0.003 22.0 noncon
hsa-miR-6839-3p 26-32 -0.257 93.0 -0.257 95.0 noncon
hsa-miR-141-5p 117-123 -0.256 95.0 -0.162 91.0 noncon
hsa-miR-4491 1803-1809 -0.256 94.0 -0.052 65.0 noncon
hsa-miR-144-3p 37-43 -0.255 96.0 -0.255 97.0 noncon
hsa-miR-6888-3p 297-304 -0.254 95.0 -0.161 92.0 noncon
hsa-miR-363-5p 232-238 -0.253 92.0 -0.16 85.0 noncon
hsa-miR-6800-3p 2242-2248 -0.25 95.0 -0.051 78.0 noncon