GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT10



General Information
Gene Symbol:   
GALNT10
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 10
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q86SR1 
NCBI GeneID:   
55568
GlyMap GeneID:   
55568
DNA aRefSeq:   
NM_198321.3 
Protein RefSeq:   
NP_938080.1 
BRENDA:   
Kinetic info.
OMIM number:   
608043
GeneCards database:   
GALNT10
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 40 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-516b-5p 1028-1035 -0.424 98.0 -0.423 99.0 noncon
hsa-miR-4632-3p 2485-2492 -0.397 92.0 -0.393 93.0 noncon
hsa-miR-1909-5p 36-43 -0.381 96.0 -0.381 98.0 noncon
hsa-miR-939-3p 1533-1540 -0.372 98.0 -0.371 98.0 noncon
hsa-miR-7160-3p 594-601 -0.358 97.0 -0.357 98.0 noncon
hsa-miR-4713-3p 3832-3839 -0.354 93.0 -0.35 94.0 noncon
hsa-miR-124-3p.1 2011-2017 -0.339 97.0 -0.336 97.0 con
hsa-miR-3620-3p 117-124 -0.336 98.0 -0.336 98.0 noncon
hsa-miR-532-3p 310-317 -0.319 98.0 -0.319 98.0 noncon
hsa-miR-194-3p 1478-1485 -0.318 97.0 -0.318 98.0 noncon
hsa-miR-4736 1470-1477 -0.309 98.0 -0.309 98.0 noncon
hsa-miR-371b-3p 82-89 -0.308 95.0 -0.308 96.0 noncon
hsa-miR-1303 4005-4012 -0.304 97.0 0.0 19.0 noncon
hsa-miR-4654 201-208 -0.301 97.0 -0.301 97.0 noncon
hsa-miR-323a-5p 3901-3908 -0.295 95.0 -0.292 96.0 noncon
hsa-miR-4645-5p 3920-3927 -0.293 98.0 -0.29 98.0 noncon
hsa-miR-3126-3p 1357-1364 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-4673 3920-3927 -0.291 98.0 -0.288 98.0 noncon
hsa-miR-1343-3p 1534-1541 -0.288 96.0 -0.288 97.0 noncon
hsa-miR-6772-5p 1365-1372 -0.288 95.0 -0.288 96.0 noncon
hsa-miR-6887-3p 2691-2698 -0.285 90.0 -0.282 92.0 noncon
hsa-miR-367-5p 263-270 -0.283 95.0 -0.283 96.0 noncon
hsa-miR-6752-3p 3851-3858 -0.279 93.0 -0.276 95.0 noncon
hsa-miR-6862-3p 2889-2896 -0.278 94.0 -0.275 96.0 noncon
hsa-miR-6782-3p 407-414 -0.275 98.0 -0.275 99.0 noncon
hsa-miR-17-3p 43-50 -0.275 98.0 -0.275 98.0 noncon
hsa-miR-4721 367-374 -0.273 92.0 -0.273 94.0 noncon
hsa-miR-4731-5p 2401-2408 -0.272 95.0 -0.269 96.0 noncon
hsa-miR-6813-3p 321-328 -0.271 96.0 -0.271 97.0 noncon
hsa-miR-4435 103-110 -0.271 94.0 -0.271 96.0 noncon
hsa-miR-671-5p 1518-1525 -0.271 94.0 -0.271 95.0 noncon
hsa-miR-6783-3p 1534-1541 -0.267 95.0 -0.267 97.0 noncon
hsa-miR-6833-5p 1505-1512 -0.267 97.0 -0.267 98.0 noncon
hsa-miR-3622b-5p 1376-1383 -0.26 94.0 -0.26 95.0 noncon
hsa-miR-5008-5p 1434-1440 -0.259 93.0 -0.259 95.0 noncon
hsa-miR-1227-5p 212-218 -0.258 94.0 -0.258 95.0 noncon
hsa-miR-1271-3p 746-753 -0.257 90.0 -0.257 93.0 noncon
hsa-miR-1233-3p 127-133 -0.253 95.0 -0.253 96.0 noncon