GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT16



General Information
Gene Symbol:   
GALNT16
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 16
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• Catalyzes the initiation of O-linked oligosaccharide biosynthesis. Part of the ~20 member ppGalNAcT family.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8N428 
NCBI GeneID:   
57452
GlyMap GeneID:   
57452
DNA aRefSeq:   
NM_001168368.1 
Protein RefSeq:   
NP_001161840.1 
BRENDA:   
Kinetic info.
OMIM number:   
615132
GeneCards database:   
GALNT16
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 10 8 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-3138 1134-1141 -0.541 99.0 0.0 5.0 noncon
hsa-miR-4278 491-498 -0.49 97.0 -0.49 98.0 noncon
hsa-miR-7845-5p 353-360 -0.448 99.0 -0.448 99.0 noncon
hsa-miR-6503-5p 237-244 -0.395 97.0 -0.395 98.0 noncon
hsa-miR-4527 237-244 -0.385 97.0 -0.385 98.0 noncon
hsa-miR-6732-5p 490-497 -0.385 97.0 -0.385 98.0 noncon
hsa-miR-1291 706-713 -0.374 96.0 -0.374 97.0 noncon
hsa-miR-3691-5p 108-115 -0.373 96.0 -0.373 97.0 noncon
hsa-miR-4764-5p 106-113 -0.372 97.0 -0.372 97.0 noncon
hsa-miR-3911 110-117 -0.368 98.0 -0.368 98.0 noncon
hsa-miR-140-5p 1120-1126 -0.361 97.0 -0.361 98.0 con
hsa-miR-6775-3p 706-713 -0.36 96.0 -0.36 96.0 noncon
hsa-miR-604 747-754 -0.358 98.0 -0.358 99.0 noncon
hsa-miR-491-5p 155-162 -0.356 97.0 -0.356 98.0 noncon
hsa-miR-2355-5p 394-401 -0.355 98.0 -0.355 98.0 noncon
hsa-miR-6857-5p 432-439 -0.348 98.0 -0.348 98.0 noncon
hsa-miR-135b-3p 228-235 -0.334 94.0 -0.334 95.0 noncon
hsa-miR-212-5p 291-298 -0.332 97.0 -0.332 97.0 noncon
hsa-miR-324-3p 249-256 -0.33 97.0 -0.33 98.0 noncon
hsa-miR-4536-5p 262-269 -0.322 94.0 -0.322 96.0 noncon
hsa-miR-4795-5p 1122-1128 -0.321 96.0 -0.321 97.0 noncon
hsa-miR-891a-3p 1065-1071 -0.312 96.0 -0.312 98.0 noncon
hsa-miR-1913 249-256 -0.312 97.0 -0.312 97.0 noncon
hsa-miR-6090 700-707 -0.304 98.0 -0.304 98.0 noncon
hsa-miR-4680-5p 312-319 -0.301 96.0 -0.301 97.0 noncon
hsa-miR-4657 299-306 -0.28 96.0 -0.28 97.0 noncon
hsa-miR-4491 299-306 -0.28 96.0 -0.28 97.0 noncon
hsa-miR-4493 942-949 -0.278 94.0 -0.278 96.0 noncon
hsa-miR-3064-3p 1011-1018 -0.277 93.0 -0.277 94.0 noncon
hsa-miR-4800-5p 1135-1141 -0.275 91.0 0.0 11.0 noncon
hsa-miR-576-3p 114-121 -0.272 96.0 -0.272 97.0 noncon
hsa-miR-6796-5p 156-162 -0.27 91.0 -0.27 93.0 noncon
hsa-miR-4750-3p 19-25 -0.262 95.0 -0.262 96.0 noncon
hsa-miR-6829-5p 1020-1026 -0.257 93.0 -0.257 95.0 noncon
hsa-miR-548au-3p 520-527 -0.255 93.0 -0.255 95.0 noncon
hsa-miR-554 848-855 -0.253 92.0 -0.253 95.0 noncon