Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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PAPS | + |
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→ |
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+ | PAP |
PAPS | + |
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→ |
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+ | PAP |
• Chondroitin sulfate chains are composed of GlcAβ1-3GalNAcβ1-4 repeating unit. Various sulfotransferases, CHST3, 7, 11, 12, 13, 14, 15, and UST, sulfate either GalNAc and GlcA residues. CS are a major functional component of aggrecan, and needed for cartilage formation and maintenance.
• This is also called CS2ST. It transfers sulfo group to C2 of GlcA or IdoA in the context of GalNAc.
• IdoA2S residue present in a highly sulfated chondroitin sulfate B (dermatan sulfate) hexasaccharide
• Does not have activity on HS
ER | Cis- | Medial- | Trans- | TGN |
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UST/hsa-miR-519c-5p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...AAACCACAAAGUCU
CUCUAGAA
...
3' GUCUUUCGCGAAGG GAGAUCU C |
8mer | 1770-1777 | -0.291 | 97.0 | -0.274 | 97.0 | noncon |