SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35B2



General Information
Gene Symbol:   
SLC35B2
Protein name:   
Adenosine 3'-phospho 5'-phosphosulfate transporter 1
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

PAPS [Cyto] → PAPS [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• SLC35B2 and B3 transfer PAPS from the cytosol into the Golgi apparatus from the cytoplasm.
• PAPS is a universal sulfuryl donor for sulfation.
• Depending on cancer type, the expression of PAPST1 and PAPST2 can increase or decrease, resulting in increases or decreases in sulfation of GAGs, respectively.
• Decreased expression of PAPST1 and PAPST2 caused FGF signaling to decrease in colorectal cells.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-174362
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8TB61 
NCBI GeneID:   
347734
GlyMap GeneID:   
347734
DNA aRefSeq:   
NM_001286509.1 
Protein RefSeq:   
NP_001273438.1 
BRENDA:   
Kinetic info.
OMIM number:   
610788
GeneCards database:   
SLC35B2
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     PAPS [Cyto]
Product:  
     PAPS [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 400 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-744-5p 340-347 -0.703 99.0 -0.703 99.0 noncon
hsa-miR-365a-3p 1493-1500 -0.651 99.0 0.0 31.0 noncon
hsa-miR-365b-3p 1493-1500 -0.651 99.0 0.0 31.0 noncon
hsa-miR-25-5p 677-684 -0.598 99.0 -0.595 99.0 noncon
hsa-miR-5682 25-32 -0.566 99.0 -0.566 99.0 noncon
hsa-miR-1273g-3p 1457-1464 -0.553 99.0 -0.001 39.0 noncon
hsa-miR-593-5p 152-159 -0.543 99.0 -0.543 99.0 noncon
hsa-miR-939-5p 348-355 -0.517 99.0 -0.517 99.0 noncon
hsa-miR-6804-5p 289-296 -0.507 98.0 -0.507 99.0 noncon
hsa-miR-29c-3p 24-31 -0.497 98.0 -0.497 99.0 noncon
hsa-miR-29b-3p 24-31 -0.497 98.0 -0.497 99.0 noncon
hsa-miR-29a-3p 24-31 -0.497 98.0 -0.497 99.0 noncon
hsa-miR-6802-3p 877-884 -0.481 99.0 -0.479 99.0 noncon
hsa-miR-665 1353-1360 -0.479 99.0 -0.477 99.0 noncon
hsa-miR-3678-3p 77-84 -0.471 99.0 -0.471 99.0 noncon
hsa-miR-7854-3p 411-418 -0.47 99.0 -0.47 99.0 noncon
hsa-miR-6766-5p 188-195 -0.457 98.0 -0.457 98.0 noncon
hsa-miR-2467-3p 1209-1216 -0.456 99.0 -0.454 99.0 noncon
hsa-miR-6866-5p 209-216 -0.456 98.0 -0.456 98.0 noncon
hsa-miR-6756-5p 188-195 -0.454 98.0 -0.454 98.0 noncon
hsa-miR-1343-5p 348-355 -0.453 99.0 -0.453 99.0 noncon
hsa-miR-6883-5p 896-903 -0.439 99.0 -0.437 99.0 noncon
hsa-miR-6801-3p 990-997 -0.439 98.0 -0.437 98.0 noncon
hsa-miR-4733-3p 1235-1242 -0.435 98.0 -0.433 99.0 noncon
hsa-miR-1229-3p 1238-1245 -0.425 98.0 -0.423 98.0 noncon
hsa-miR-4505 352-359 -0.422 98.0 -0.422 99.0 noncon
hsa-miR-124-3p.2 1028-1035 -0.416 97.0 -0.414 98.0 con
hsa-miR-548av-3p 1055-1062 -0.415 99.0 -0.413 99.0 noncon
hsa-miR-6753-3p 974-981 -0.408 97.0 -0.406 98.0 noncon
hsa-miR-7107-3p 974-981 -0.408 97.0 -0.406 98.0 noncon
hsa-miR-4520-3p 131-138 -0.408 99.0 -0.408 99.0 noncon
hsa-miR-149-3p 896-903 -0.407 98.0 -0.405 98.0 noncon
hsa-miR-4728-5p 896-903 -0.405 98.0 -0.403 99.0 noncon
hsa-miR-6785-5p 896-903 -0.405 98.0 -0.403 99.0 noncon
hsa-miR-324-5p 1315-1322 -0.405 96.0 -0.403 97.0 noncon
hsa-miR-4693-3p 363-370 -0.401 98.0 -0.401 98.0 noncon
hsa-miR-3678-3p 1210-1217 -0.4 99.0 -0.398 99.0 noncon
hsa-miR-6810-3p 990-997 -0.397 97.0 -0.395 98.0 noncon
hsa-miR-6892-5p 1159-1166 -0.396 98.0 -0.394 99.0 noncon
hsa-miR-4722-3p 422-429 -0.395 99.0 -0.395 99.0 noncon
hsa-miR-6865-3p 1284-1291 -0.392 98.0 -0.39 98.0 noncon
hsa-miR-5192 589-596 -0.384 99.0 -0.382 99.0 noncon
hsa-miR-3130-3p 457-464 -0.383 99.0 -0.381 99.0 noncon
hsa-miR-6511b-3p 1237-1244 -0.379 97.0 -0.377 98.0 noncon
hsa-miR-6727-3p 422-429 -0.377 99.0 -0.377 99.0 noncon
hsa-miR-5787 352-359 -0.376 99.0 -0.376 99.0 noncon
hsa-miR-4713-3p 1358-1364 -0.373 94.0 -0.371 95.0 noncon
hsa-miR-7160-3p 525-532 -0.372 97.0 -0.37 98.0 noncon
hsa-miR-6511a-3p 1237-1244 -0.371 97.0 -0.369 98.0 noncon
hsa-miR-4327 80-87 -0.371 98.0 -0.371 98.0 noncon
hsa-miR-218-5p 1246-1253 -0.371 97.0 -0.369 98.0 con
hsa-miR-6822-5p 1157-1163 -0.363 99.0 -0.361 99.0 noncon
hsa-miR-624-5p 1397-1403 -0.356 96.0 -0.354 97.0 noncon
hsa-miR-412-3p 1287-1294 -0.356 98.0 -0.354 98.0 noncon
hsa-miR-4471 1156-1162 -0.353 96.0 -0.351 97.0 noncon
hsa-miR-6750-5p 1157-1163 -0.352 99.0 -0.35 99.0 noncon
hsa-miR-4257 922-929 -0.351 99.0 -0.349 99.0 noncon
hsa-miR-6510-5p 582-589 -0.347 98.0 -0.345 98.0 noncon
hsa-miR-6754-3p 1287-1294 -0.346 98.0 -0.344 98.0 noncon
hsa-miR-4435 200-207 -0.345 97.0 -0.345 98.0 noncon
hsa-miR-1911-5p 114-120 -0.344 95.0 -0.344 96.0 noncon
hsa-miR-6815-5p 1188-1194 -0.343 97.0 -0.341 98.0 noncon
hsa-miR-6865-5p 1188-1194 -0.343 97.0 -0.341 98.0 noncon
hsa-miR-506-3p 1028-1035 -0.34 96.0 -0.338 97.0 con
hsa-miR-6763-3p 812-818 -0.339 92.0 -0.337 94.0 noncon
hsa-miR-6721-5p 1327-1334 -0.337 96.0 -0.335 97.0 noncon
hsa-miR-6784-5p 88-94 -0.337 93.0 -0.337 94.0 noncon
hsa-miR-6753-5p 1234-1240 -0.334 97.0 -0.332 98.0 noncon
hsa-miR-6840-5p 1072-1078 -0.328 91.0 -0.326 93.0 noncon
hsa-miR-6797-3p 227-233 -0.326 97.0 -0.326 98.0 noncon
hsa-miR-7152-3p 332-339 -0.324 96.0 -0.324 97.0 noncon
hsa-miR-6076 227-233 -0.316 96.0 -0.316 97.0 noncon
hsa-miR-6780b-5p 184-191 -0.315 95.0 -0.315 96.0 noncon
hsa-miR-6829-5p 85-91 -0.312 96.0 -0.312 97.0 noncon
hsa-miR-4679 971-978 -0.303 98.0 -0.302 98.0 noncon
hsa-miR-938 1491-1497 -0.302 97.0 0.0 11.0 noncon
hsa-miR-6865-3p 858-864 -0.3 96.0 -0.299 97.0 noncon
hsa-miR-6846-3p 1113-1119 -0.298 94.0 -0.297 96.0 noncon
hsa-miR-939-3p 1005-1012 -0.295 96.0 -0.294 97.0 noncon
hsa-miR-6851-3p 867-873 -0.293 95.0 -0.292 97.0 noncon
hsa-miR-4725-3p 184-191 -0.291 94.0 -0.291 95.0 noncon
hsa-miR-548k 1399-1406 -0.29 98.0 -0.289 99.0 noncon
hsa-miR-6509-3p 1458-1464 -0.289 96.0 -0.001 25.0 noncon
hsa-miR-4266 1344-1350 -0.288 93.0 -0.287 95.0 noncon
hsa-miR-509-3-5p 1455-1461 -0.286 98.0 -0.001 47.0 noncon
hsa-miR-4734 342-348 -0.286 91.0 -0.286 93.0 noncon
hsa-miR-3065-3p 1296-1302 -0.285 96.0 -0.284 97.0 noncon
hsa-miR-3157-5p 936-943 -0.285 96.0 -0.284 97.0 noncon
hsa-miR-6791-3p 1009-1016 -0.285 97.0 -0.284 98.0 noncon
hsa-miR-4283 1067-1073 -0.284 92.0 -0.283 94.0 noncon
hsa-miR-6858-3p 934-940 -0.283 97.0 -0.282 98.0 noncon
hsa-miR-6893-5p 705-711 -0.282 98.0 -0.281 98.0 noncon
hsa-miR-6808-5p 705-711 -0.282 98.0 -0.281 98.0 noncon
hsa-miR-4519 510-517 -0.282 96.0 -0.281 97.0 noncon
hsa-miR-3157-3p 944-950 -0.282 97.0 -0.281 97.0 noncon
hsa-miR-6836-5p 581-587 -0.281 94.0 -0.28 95.0 noncon
hsa-miR-658 676-682 -0.281 90.0 -0.28 92.0 noncon
hsa-miR-509-5p 1455-1461 -0.275 98.0 -0.001 47.0 noncon
hsa-miR-4470 436-442 -0.275 97.0 -0.275 98.0 noncon
hsa-miR-548av-5p 1399-1406 -0.274 98.0 -0.273 99.0 noncon
hsa-miR-3972 43-49 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-6851-5p 1342-1348 -0.272 92.0 -0.271 94.0 noncon
hsa-miR-3691-3p 1463-1469 -0.271 96.0 -0.001 42.0 noncon
hsa-miR-4696 1167-1173 -0.269 96.0 -0.268 97.0 noncon
hsa-miR-8059 1156-1162 -0.269 95.0 -0.268 97.0 noncon
hsa-miR-1262 1037-1043 -0.267 95.0 -0.266 96.0 noncon
hsa-miR-3913-3p 448-454 -0.266 93.0 -0.266 95.0 noncon
hsa-miR-17-3p 1454-1460 -0.265 97.0 -0.001 38.0 noncon
hsa-miR-1827 490-496 -0.264 94.0 -0.263 95.0 noncon
hsa-miR-2467-3p 77-83 -0.263 95.0 -0.263 96.0 noncon
hsa-miR-6132 581-587 -0.263 92.0 -0.262 94.0 noncon
hsa-miR-489-3p 448-454 -0.262 98.0 -0.262 98.0 noncon
hsa-miR-6829-3p 1009-1016 -0.261 96.0 -0.26 97.0 noncon
hsa-miR-4733-3p 22-28 -0.261 95.0 -0.261 97.0 noncon
hsa-miR-1271-5p 154-160 -0.258 93.0 -0.258 95.0 noncon
hsa-miR-4701-3p 1037-1043 -0.256 95.0 -0.255 96.0 noncon
hsa-miR-7974 284-290 -0.256 90.0 -0.256 93.0 noncon
hsa-miR-644a 720-726 -0.256 92.0 -0.255 95.0 noncon
hsa-miR-3148 1512-1519 -0.254 99.0 0.0 26.0 noncon
hsa-miR-6729-3p 1314-1320 -0.253 92.0 -0.252 94.0 noncon
hsa-miR-585-5p 26-32 -0.253 90.0 -0.253 93.0 noncon
hsa-miR-6736-5p 1037-1043 -0.252 94.0 -0.251 96.0 noncon
hsa-miR-3189-5p 96-103 -0.251 95.0 -0.251 97.0 noncon
hsa-miR-6846-3p 473-479 -0.25 92.0 -0.249 94.0 noncon
hsa-miR-4722-3p 384-390 -0.25 95.0 -0.25 96.0 noncon