Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Glycogene class |
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Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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→ |
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• DS is derived from CS by the epimerization of GlcA to IdoA. By definition, a single iduronic acid is sufficient to name the chain DS
• Dermatan sulfate epimerase 1 and 2 epimerize glucuronic acid to iduronic acid in DS
• After epimerization of the chain, the C2 hydroxyl group of GlcA/IdoA and the C4 and/or C6 hydroxyl group of GalNAc can be sulfated, giving rise to seven different disaccharide structures
• Disregulation of the epimerase activity results in the propagation of various inflammatory and oncological disorders
ER | Cis- | Medial- | Trans- | TGN |
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DSEL/hsa-miR-3666 |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...GGUCAGCAGAAAU
UUGCACUA
...
3' AGCCGUAGAUGUG AACGUGA C |
8mer | 22-29 | -0.495 | 99.0 | -0.495 | 99.0 | con |