EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 

Pathway Map

CHST9



General Information
Gene Symbol:   
CHST9
Protein name:   
Carbohydrate sulfotransferase 9
Enzyme Class:   
Sulfate synthase
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   
PAPS +
+ PAP
Reaction (IUBMB):   
No specified reaction.

About

• Catalyzes C4 sulfation of GalNAc in GalNAc(β1-4)GlcNAcβ on N- and O-glycans.
• Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin


Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
Reactome:   

Related Database
Organism:   
Homo sapiens
Uniprot:   
NCBI GeneID:   
GlyMap GeneID:   
DNA aRefSeq:   
Protein RefSeq:   
BRENDA:   
OMIM number:   
GeneCards database:   

Enzyme Specificity
Glycan Type:  
     N-linked, O-linked (mucin type)
Compartment:  
     
Substrate:  
     GalNAc(b1-4)GlcNAc(b1-?)
Product:  
     GalNAc(b1-4 [4S])GlcNAc(b1-?)

Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN











Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000581714 ENST00000618847 CTCF KDM5C NR2F2 JUND RXRA ZBTB26 GATAD2A RARA RXRB SMAD4 SOX13 SOX13 CREB1 YY1 ATF3 HMG20A TEAD4 TEAD4 RUNX1 MAX DMAP1 USF1 HNF1B HMG20A CEBPG CEBPG MIXL1 SOX5 GATA4 HNF1A TEAD1 FOXA2 BCL6 HNF4A SOX13 ZNF7 ZNF3 ZKSCAN1


miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-5581-5p 1584-1591 -0.714 99.0 -0.229 92.0 noncon
hsa-miR-4297 1584-1591 -0.68 99.0 -0.22 91.0 noncon
hsa-miR-6747-5p 622-629 -0.641 99.0 -0.641 99.0 noncon
hsa-miR-6069 1335-1342 -0.635 99.0 -0.635 99.0 noncon
hsa-miR-6887-3p 83-90 -0.602 99.0 -0.602 99.0 noncon
hsa-miR-6812-5p 623-630 -0.579 99.0 -0.579 99.0 noncon
hsa-miR-4725-5p 111-118 -0.578 99.0 -0.578 99.0 noncon
hsa-miR-6737-5p 623-630 -0.577 99.0 -0.577 99.0 noncon
hsa-miR-6819-5p 623-630 -0.577 99.0 -0.577 99.0 noncon
hsa-miR-421 1483-1490 -0.546 99.0 -0.474 99.0 noncon
hsa-miR-3118 323-330 -0.546 99.0 -0.546 99.0 noncon
hsa-miR-4646-3p 609-616 -0.541 99.0 -0.541 99.0 noncon
hsa-miR-1233-5p 469-476 -0.54 99.0 -0.54 99.0 noncon
hsa-miR-6778-5p 469-476 -0.54 99.0 -0.54 99.0 noncon
hsa-miR-4709-5p 1482-1489 -0.532 99.0 -0.462 99.0 noncon
hsa-miR-188-5p 528-535 -0.531 99.0 -0.531 99.0 noncon
hsa-miR-4642 863-870 -0.531 99.0 -0.531 99.0 noncon
hsa-miR-6895-3p 998-1005 -0.53 99.0 -0.53 99.0 noncon
hsa-miR-134-5p 323-330 -0.53 99.0 -0.53 99.0 noncon
hsa-miR-4687-3p 1656-1663 -0.521 99.0 0.0 20.0 noncon
hsa-miR-624-5p 432-439 -0.514 99.0 -0.514 99.0 noncon
hsa-miR-5706 346-353 -0.511 99.0 -0.511 99.0 noncon
hsa-miR-4782-5p 346-353 -0.503 99.0 -0.503 99.0 noncon
hsa-miR-3681-5p 737-744 -0.491 99.0 -0.491 99.0 noncon
hsa-miR-1243 642-649 -0.489 99.0 -0.489 99.0 noncon
hsa-miR-6736-3p 901-908 -0.478 99.0 -0.478 99.0 noncon
hsa-miR-6869-5p 29-36 -0.475 99.0 -0.475 99.0 noncon
hsa-miR-2467-3p 453-460 -0.463 99.0 -0.463 99.0 noncon
hsa-miR-337-3p 1233-1240 -0.454 99.0 -0.454 99.0 noncon
hsa-miR-675-3p 458-465 -0.45 99.0 -0.45 99.0 noncon
hsa-miR-6866-3p 528-535 -0.45 99.0 -0.45 99.0 noncon
hsa-miR-376c-3p 354-361 -0.447 99.0 -0.447 99.0 noncon
hsa-miR-1257 74-81 -0.446 99.0 -0.446 99.0 noncon
hsa-miR-215-3p 1151-1158 -0.434 99.0 -0.434 99.0 noncon
hsa-miR-628-5p 794-801 -0.432 99.0 -0.432 99.0 noncon
hsa-miR-1279 1604-1611 -0.429 99.0 -0.147 97.0 noncon
hsa-miR-6818-3p 999-1006 -0.429 99.0 -0.429 99.0 noncon
hsa-miR-5002-5p 1201-1208 -0.422 99.0 -0.422 99.0 noncon
hsa-miR-1909-5p 930-936 -0.416 97.0 -0.416 98.0 noncon
hsa-miR-155-5p 697-704 -0.415 98.0 -0.415 99.0 noncon
hsa-miR-29b-1-5p 1625-1632 -0.414 99.0 0.0 32.0 noncon
hsa-miR-6875-3p 240-247 -0.414 99.0 -0.414 99.0 noncon
hsa-miR-6849-5p 737-744 -0.399 99.0 -0.399 99.0 noncon
hsa-miR-154-5p 1331-1338 -0.398 99.0 -0.398 99.0 noncon
hsa-miR-6832-3p 526-533 -0.398 99.0 -0.398 99.0 noncon
hsa-miR-137 1327-1334 -0.392 96.0 -0.392 97.0 con
hsa-miR-3977 1324-1331 -0.391 99.0 -0.391 99.0 noncon
hsa-miR-3685 1377-1384 -0.39 99.0 -0.39 99.0 noncon
hsa-miR-4425 913-919 -0.383 96.0 -0.383 97.0 noncon
hsa-miR-6823-5p 1088-1094 -0.38 98.0 -0.38 99.0 noncon
hsa-miR-412-5p 676-682 -0.375 90.0 -0.375 92.0 noncon
hsa-miR-3194-5p 400-406 -0.375 97.0 -0.375 98.0 noncon
hsa-miR-5010-3p 370-377 -0.362 99.0 -0.362 99.0 noncon
hsa-miR-4528 1526-1533 -0.36 99.0 -0.315 99.0 noncon
hsa-miR-6772-5p 1500-1506 -0.357 97.0 -0.313 97.0 noncon
hsa-miR-9-3p 94-101 -0.356 98.0 -0.356 99.0 noncon
hsa-miR-4660 1294-1300 -0.353 97.0 -0.353 97.0 noncon
hsa-miR-5580-5p 1338-1344 -0.35 96.0 -0.35 97.0 noncon
hsa-miR-103a-2-5p 693-700 -0.349 98.0 -0.349 98.0 noncon
hsa-miR-513a-5p 687-694 -0.348 98.0 -0.348 99.0 noncon
hsa-miR-7973 113-119 -0.347 95.0 -0.347 97.0 noncon
hsa-miR-6759-3p 790-797 -0.347 97.0 -0.347 98.0 noncon
hsa-miR-193b-3p 189-195 -0.344 95.0 -0.344 97.0 noncon
hsa-miR-193a-3p 189-195 -0.344 95.0 -0.344 97.0 noncon
hsa-miR-4760-3p 1310-1317 -0.343 99.0 -0.343 99.0 noncon
hsa-miR-4259 914-920 -0.343 96.0 -0.343 97.0 noncon
hsa-miR-4743-3p 1153-1160 -0.342 99.0 -0.342 99.0 noncon
hsa-miR-4793-3p 1169-1175 -0.333 98.0 -0.333 99.0 noncon
hsa-miR-6802-3p 308-314 -0.331 95.0 -0.331 97.0 noncon
hsa-miR-6514-5p 1055-1061 -0.322 98.0 -0.322 98.0 noncon
hsa-miR-568 1048-1055 -0.319 98.0 -0.319 99.0 noncon
hsa-miR-4277 992-999 -0.318 98.0 -0.318 99.0 noncon
hsa-miR-6858-3p 401-407 -0.317 98.0 -0.317 98.0 noncon
hsa-miR-1207-3p 1340-1346 -0.311 98.0 -0.311 98.0 noncon
hsa-miR-6826-3p 84-90 -0.311 94.0 -0.311 96.0 noncon
hsa-miR-7159-5p 1320-1327 -0.308 98.0 -0.308 98.0 noncon
hsa-miR-6786-5p 756-762 -0.306 92.0 -0.306 94.0 noncon
hsa-miR-432-3p 640-646 -0.301 95.0 -0.301 96.0 noncon
hsa-miR-3190-5p 188-194 -0.297 97.0 -0.297 98.0 noncon
hsa-miR-6762-3p 1360-1366 -0.296 95.0 -0.296 96.0 noncon
hsa-miR-6784-3p 309-315 -0.296 95.0 -0.296 96.0 noncon
hsa-miR-4501 325-331 -0.296 97.0 -0.296 98.0 noncon
hsa-miR-1246 1536-1542 -0.294 97.0 -0.258 97.0 noncon
hsa-miR-6074 1445-1452 -0.294 99.0 -0.294 99.0 noncon
hsa-miR-519e-3p 929-935 -0.293 95.0 -0.293 96.0 noncon
hsa-miR-6862-3p 309-315 -0.293 95.0 -0.293 96.0 noncon
hsa-miR-372-5p 844-851 -0.293 99.0 -0.293 99.0 noncon
hsa-miR-4667-3p 82-88 -0.292 96.0 -0.292 97.0 noncon
hsa-miR-132-3p 157-163 -0.29 98.0 -0.29 98.0 noncon
hsa-miR-6072 1631-1637 -0.288 95.0 0.0 29.0 noncon
hsa-miR-376b-3p 1011-1017 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-376a-3p 1011-1017 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-671-5p 448-454 -0.286 94.0 -0.286 96.0 noncon
hsa-miR-3184-3p 848-854 -0.285 97.0 -0.285 98.0 noncon
hsa-miR-4778-3p 857-864 -0.285 97.0 -0.285 97.0 noncon
hsa-miR-376b-5p 736-742 -0.284 93.0 -0.284 95.0 noncon
hsa-miR-4279 251-257 -0.283 97.0 -0.283 97.0 noncon
hsa-miR-3663-3p 890-896 -0.279 91.0 -0.279 94.0 noncon
hsa-miR-212-3p 157-163 -0.279 97.0 -0.279 98.0 noncon
hsa-miR-3607-3p 877-884 -0.279 98.0 -0.279 98.0 noncon
hsa-miR-548a-5p 1572-1579 -0.278 99.0 -0.098 94.0 noncon
hsa-miR-450b-3p 578-584 -0.277 96.0 -0.277 97.0 noncon
hsa-miR-3170 624-630 -0.277 95.0 -0.277 96.0 noncon
hsa-miR-155-3p 1377-1383 -0.277 92.0 -0.277 95.0 noncon
hsa-miR-3614-5p 1166-1172 -0.277 97.0 -0.277 98.0 noncon
hsa-miR-532-5p 1586-1592 -0.276 96.0 -0.098 88.0 noncon
hsa-miR-4698 1540-1547 -0.275 99.0 -0.242 99.0 noncon
hsa-miR-6891-3p 1631-1637 -0.274 94.0 0.0 33.0 noncon
hsa-miR-7853-5p 496-503 -0.273 98.0 -0.273 99.0 noncon
hsa-miR-550b-2-5p 1223-1229 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-3064-3p 1465-1471 -0.271 92.0 -0.271 94.0 noncon
hsa-miR-548bb-5p 1572-1579 -0.27 99.0 -0.096 93.0 noncon
hsa-miR-548ap-5p 1572-1579 -0.27 99.0 -0.096 94.0 noncon
hsa-miR-4272 1485-1491 -0.27 98.0 -0.237 98.0 noncon
hsa-miR-548ar-5p 1572-1579 -0.27 99.0 -0.096 93.0 noncon
hsa-miR-548j-5p 1572-1579 -0.27 99.0 -0.096 94.0 noncon
hsa-miR-548y 1572-1579 -0.27 99.0 -0.096 93.0 noncon
hsa-miR-5586-5p 748-754 -0.269 95.0 -0.269 96.0 noncon
hsa-miR-6849-3p 399-405 -0.268 97.0 -0.268 98.0 noncon
hsa-miR-559 1572-1579 -0.268 99.0 -0.095 94.0 noncon
hsa-miR-6855-5p 624-630 -0.268 94.0 -0.268 96.0 noncon
hsa-miR-30c-1-3p 468-474 -0.268 97.0 -0.268 98.0 noncon
hsa-miR-33b-3p 929-935 -0.267 94.0 -0.267 96.0 noncon
hsa-miR-105-5p 496-503 -0.265 98.0 -0.265 99.0 noncon
hsa-miR-544a 1619-1625 -0.264 95.0 -0.094 79.0 noncon
hsa-miR-640 88-94 -0.263 95.0 -0.263 96.0 noncon
hsa-miR-548ay-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548h-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548w 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548o-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548i 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548b-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548am-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548as-5p 1572-1579 -0.262 99.0 -0.093 94.0 noncon
hsa-miR-548ak 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548ae-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548c-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548au-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548d-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548ad-5p 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-548ab 1572-1579 -0.262 99.0 -0.093 93.0 noncon
hsa-miR-452-3p 881-887 -0.262 97.0 -0.262 97.0 noncon
hsa-miR-8058 104-110 -0.261 94.0 -0.261 96.0 noncon
hsa-miR-609 621-627 -0.261 92.0 -0.261 94.0 noncon
hsa-miR-5572 624-630 -0.26 96.0 -0.26 97.0 noncon
hsa-miR-4433b-5p 609-615 -0.258 92.0 -0.258 94.0 noncon
hsa-miR-942-5p 124-130 -0.255 96.0 -0.255 97.0 noncon
hsa-miR-5009-5p 104-110 -0.253 93.0 -0.253 95.0 noncon
hsa-miR-6738-3p 1619-1625 -0.253 94.0 -0.09 83.0 noncon
hsa-miR-4699-5p 23-29 -0.25 96.0 -0.25 97.0 noncon