Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (firstname.lastname@example.org), Yusen Zhou (email@example.com) or Ted Groth (firstname.lastname@example.org).
• MGAT4 catalyzes β1-4GlcNAc linkage to the GlcNAcβ1-2Manα1,3 arm of N-glycans.
• Two isoenzymes MGAT4A and MGAT4B, both of which have different tissue distributions, contribute to cellular MGAT4/GnT-IV activity. A third enzyme has also been reported but is not characterized.
• MGAT4 and MGAT5 both contribute to N-glycan branching, and they are ubiquitously expressed in various organs.
• N-glycan branching due to GnT-IVa may be aberrantly upregulated in some type of tumors and this can serve as a biomarker.