SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT1A1



General Information
Gene Symbol:   
UGT1A1
Protein name:   
UDP-glucuronosyltransferase 1A1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Organs:   
Reaction (SNFG):   
+ R →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Genetic defects in UGT1A1 sequences cause Cringer-Najar syndrome, which prevents the excretion of bilirubin from the liver.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
P22309 
NCBI GeneID:   
54658
GlyMap GeneID:   
54658
DNA aRefSeq:   
NM_000463.2 
Protein RefSeq:   
NP_000454.1 
BRENDA:   
Kinetic info.
OMIM number:   
191740
GeneCards database:   
UGT1A1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 260 240 220 200 180 160 140 120 100 80 60 40 20 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 50 40 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-185-3p 121-128 -0.703 99.0 -0.703 99.0 noncon
hsa-miR-8065 699-706 -0.521 98.0 -0.521 99.0 noncon
hsa-miR-6736-3p 629-636 -0.516 99.0 -0.516 99.0 noncon
hsa-miR-6839-3p 646-653 -0.466 98.0 -0.466 99.0 noncon
hsa-miR-491-3p 108-115 -0.453 98.0 -0.453 98.0 noncon
hsa-miR-3194-5p 263-270 -0.427 98.0 -0.427 99.0 noncon
hsa-miR-141-3p 69-76 -0.425 99.0 -0.425 99.0 con
hsa-miR-200a-3p 69-76 -0.425 99.0 -0.425 99.0 con
hsa-miR-3121-3p 738-745 -0.391 99.0 -0.391 99.0 noncon
hsa-miR-5093 45-52 -0.355 99.0 -0.355 99.0 noncon
hsa-miR-5088-3p 471-478 -0.354 98.0 -0.354 98.0 noncon
hsa-miR-6835-3p 131-138 -0.35 99.0 -0.35 99.0 noncon
hsa-miR-6743-5p 342-349 -0.335 97.0 -0.335 97.0 noncon
hsa-miR-4688 342-349 -0.333 96.0 -0.333 97.0 noncon
hsa-miR-218-2-3p 30-36 -0.317 97.0 -0.317 98.0 noncon
hsa-miR-3158-5p 384-391 -0.315 98.0 -0.315 98.0 noncon
hsa-miR-4793-5p 224-231 -0.313 98.0 -0.313 98.0 noncon
hsa-miR-4496 697-704 -0.303 99.0 -0.303 99.0 noncon
hsa-miR-4656 120-126 -0.302 97.0 -0.302 97.0 noncon
hsa-miR-4509 488-495 -0.296 98.0 -0.296 98.0 noncon
hsa-miR-8089 124-130 -0.295 96.0 -0.295 97.0 noncon
hsa-miR-6716-5p 34-40 -0.291 94.0 -0.291 96.0 noncon
hsa-miR-4999-5p 655-661 -0.29 94.0 -0.29 96.0 noncon
hsa-miR-135b-3p 701-707 -0.29 90.0 -0.29 93.0 noncon
hsa-miR-4667-5p 124-130 -0.287 95.0 -0.287 96.0 noncon
hsa-miR-183-5p.1 235-241 -0.286 95.0 -0.286 96.0 noncon
hsa-miR-152-3p 526-533 -0.285 93.0 -0.285 95.0 noncon
hsa-miR-148b-3p 526-533 -0.285 93.0 -0.285 95.0 noncon
hsa-miR-148a-3p 526-533 -0.285 93.0 -0.285 95.0 noncon
hsa-miR-3123 143-149 -0.271 99.0 -0.271 99.0 noncon
hsa-miR-4489 122-128 -0.268 95.0 -0.268 96.0 noncon
hsa-miR-1972 300-306 -0.266 95.0 -0.266 97.0 noncon
hsa-miR-3972 264-270 -0.263 94.0 -0.263 96.0 noncon
hsa-miR-6865-5p 453-459 -0.254 93.0 -0.254 95.0 noncon
hsa-miR-6815-5p 453-459 -0.254 93.0 -0.254 95.0 noncon
hsa-miR-4700-5p 124-130 -0.25 94.0 -0.25 95.0 noncon