SubPathClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
TSTA3



General Information
Gene Symbol:   
TSTA3
Protein name:   
GDP-L-fucose synthase
Enzyme Class:   
CAZy Family:   
E.C. No:   
1.1.1.271
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   

GDP-4-keto-6-deoxy-D-mannose → GDP-fucose
Reaction (IUBMB):   
No specified reaction.
About

• Synthesizes GDP-fucose GDP-4-keto-6-deoxy-D-mannose via an epimerization and reduction reaction which utilizes NADPH.
• Tissue-specific transplantation antigen (TSTA3) is a known cancer biomarker at the transcriptional level

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-6787639
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q13630 
NCBI GeneID:   
7264
GlyMap GeneID:   
7264
DNA aRefSeq:   
NM_001317783.1 
Protein RefSeq:   
NP_001304712.1 
BRENDA:   
Kinetic info.
OMIM number:   
137020
GeneCards database:   
TSTA3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     GDP-4-keto-6-deoxy-D-mannose
Product:  
     GDP-fucose
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 60 50 40 30 20 10 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-4751 167-174 -0.617 99.0 -0.617 99.0 noncon
hsa-miR-1343-5p 209-216 -0.565 99.0 -0.565 99.0 noncon
hsa-miR-4763-3p 69-76 -0.564 99.0 -0.564 99.0 noncon
hsa-miR-491-5p 211-218 -0.562 99.0 -0.562 99.0 noncon
hsa-miR-1207-5p 69-76 -0.546 99.0 -0.546 99.0 noncon
hsa-miR-939-5p 209-216 -0.533 99.0 -0.533 99.0 noncon
hsa-miR-125b-5p 171-178 -0.493 99.0 -0.493 99.0 con
hsa-miR-1915-3p 260-267 -0.486 99.0 -0.353 99.0 noncon
hsa-miR-4319 171-178 -0.485 99.0 -0.485 99.0 con
hsa-miR-125a-5p 171-178 -0.469 98.0 -0.469 99.0 con
hsa-miR-6811-3p 286-292 -0.468 99.0 -0.086 78.0 noncon
hsa-miR-185-3p 127-134 -0.467 97.0 -0.467 98.0 noncon
hsa-miR-6764-5p 260-267 -0.465 99.0 -0.338 99.0 noncon
hsa-miR-6805-5p 222-228 -0.442 98.0 -0.442 98.0 noncon
hsa-miR-8073 72-79 -0.43 99.0 -0.43 99.0 noncon
hsa-miR-221-5p 72-79 -0.43 99.0 -0.43 99.0 noncon
hsa-miR-3939 228-234 -0.405 92.0 -0.405 94.0 noncon
hsa-miR-6846-5p 221-227 -0.398 95.0 -0.398 96.0 noncon
hsa-miR-3194-5p 36-43 -0.393 98.0 -0.393 98.0 noncon
hsa-miR-6848-5p 221-227 -0.387 94.0 -0.387 95.0 noncon
hsa-miR-1293 89-96 -0.375 98.0 -0.375 98.0 noncon
hsa-miR-6736-3p 77-84 -0.359 98.0 -0.359 98.0 noncon
hsa-miR-296-5p 149-155 -0.359 94.0 -0.359 95.0 noncon
hsa-miR-759 238-245 -0.339 99.0 -0.249 98.0 noncon
hsa-miR-6796-5p 212-218 -0.338 95.0 -0.338 96.0 noncon
hsa-miR-4745-5p 254-260 -0.328 95.0 -0.242 91.0 noncon
hsa-miR-4325 275-281 -0.319 97.0 -0.235 96.0 noncon
hsa-miR-4498 219-225 -0.306 93.0 -0.306 94.0 noncon
hsa-miR-4654 252-258 -0.305 97.0 -0.225 95.0 noncon
hsa-miR-6722-3p 224-230 -0.304 94.0 -0.304 95.0 noncon
hsa-miR-4758-3p 147-153 -0.304 95.0 -0.304 97.0 noncon
hsa-miR-5589-5p 92-99 -0.299 99.0 -0.299 99.0 noncon
hsa-miR-6728-5p 251-257 -0.292 97.0 -0.216 95.0 noncon
hsa-miR-4483 89-96 -0.291 98.0 -0.291 98.0 noncon
hsa-miR-4697-5p 152-158 -0.29 92.0 -0.29 93.0 noncon
hsa-miR-5001-5p 219-225 -0.285 92.0 -0.285 93.0 noncon
hsa-miR-6829-5p 126-132 -0.283 94.0 -0.283 96.0 noncon
hsa-miR-873-5p.2 246-252 -0.281 97.0 -0.208 94.0 noncon
hsa-miR-6798-5p 223-229 -0.281 94.0 -0.281 96.0 noncon
hsa-miR-6511b-5p 106-112 -0.279 95.0 -0.279 96.0 noncon
hsa-miR-563 64-70 -0.278 93.0 -0.278 95.0 noncon
hsa-miR-380-5p 64-70 -0.277 93.0 -0.277 95.0 noncon
hsa-miR-6811-5p 106-112 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-5187-5p 251-257 -0.271 93.0 -0.201 90.0 noncon
hsa-miR-1909-3p 224-230 -0.268 92.0 -0.268 94.0 noncon
hsa-miR-762 219-225 -0.266 94.0 -0.266 95.0 noncon
hsa-miR-4481 254-260 -0.266 94.0 -0.197 91.0 noncon
hsa-miR-4270 258-264 -0.26 95.0 -0.193 92.0 noncon
hsa-miR-4260 129-135 -0.256 93.0 -0.256 95.0 noncon
hsa-miR-1286 246-252 -0.25 95.0 -0.185 94.0 noncon