Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• MGAT1 or GnT1 catalyzes the transfer of β1,2-linked GlcNAc from UDP-GlcNAc to the terminal α1,3-linked Man in Man5GlcNAc2Asn to initiate the synthesis of hybrid and complex N-glycans. This results in a substrate for a-mannosidase II (MAN2A1).
• If MA2A1 does not act then a hybrid structure may be formed by the addition of Gal & sialic acid to the GlcNAc.
• Mice with a null mutation in the Mgat1 gene die at E9.5.