FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
IDUA



General Information
Gene Symbol:   
IDUA
Protein name:   
Alpha-L-iduronidase
Enzyme Class:   
Glycosidase
CAZy Family:   
GH39
E.C. No:   
3.2.1.76
Organs:   
Reaction (SNFG):   
IDUA IDUA
H2O +
→
+
H2O +
→
+
Reaction (IUBMB):   
No specified reaction.
About

• Alpha L iduronidase hydrolyzes iduronic acid from dermatan and heparan sulfates.
• Deficiencies in this enzyme cause mucopolysaccharidiosis (Hunter's syndrome) due to the lack of clearance and processing of glycosaminoglycans. The disease manifests early in life and causes a wide array of bodily dysregulation such as joint stiffness, cognitive impairment and neurodegeneration.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-2024096
Related Database
Organism:   
Homo sapiens
Uniprot:   
P35475 
NCBI GeneID:   
3425
GlyMap GeneID:   
3425
DNA aRefSeq:   
NM_000203.4 
Protein RefSeq:   
NP_000194.2 
BRENDA:   
Kinetic info.
OMIM number:   
252800
GeneCards database:   
IDUA
Enzyme Specificity
Glycan Type:  
     GAG
Compartment:  
     
Substrate:  
     IdoA(a1-3)GalNAc(b1-4) or IdoA(a1-4)GlcNAc(a1-4)
Product:  
     GalNAc(b1-4) or GlcNAc(a1-4)
Constraints:  
     None
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 6 4 2 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-1263 133-140 -0.9 99.0 -0.001 19.0 noncon
hsa-miR-6825-3p 40-47 -0.608 99.0 -0.608 99.0 noncon
hsa-miR-7110-5p 83-89 -0.59 98.0 -0.59 98.0 noncon
hsa-miR-149-3p 74-81 -0.575 99.0 -0.575 99.0 noncon
hsa-miR-1237-5p 141-147 -0.563 99.0 -0.001 13.0 noncon
hsa-miR-6883-5p 74-81 -0.559 99.0 -0.559 99.0 noncon
hsa-miR-4488 141-147 -0.556 99.0 -0.001 11.0 noncon
hsa-miR-4697-5p 141-147 -0.556 99.0 -0.001 11.0 noncon
hsa-miR-4728-5p 74-81 -0.549 99.0 -0.549 99.0 noncon
hsa-miR-6842-5p 83-89 -0.546 97.0 -0.546 98.0 noncon
hsa-miR-6785-5p 74-81 -0.541 99.0 -0.541 99.0 noncon
hsa-miR-5002-3p 36-43 -0.537 99.0 -0.537 99.0 noncon
hsa-miR-6805-5p 142-148 -0.508 99.0 0.0 15.0 noncon
hsa-miR-6752-5p 83-89 -0.495 98.0 -0.495 98.0 noncon
hsa-miR-6732-5p 84-90 -0.48 99.0 -0.48 99.0 noncon
hsa-miR-527 89-96 -0.475 99.0 -0.475 99.0 noncon
hsa-miR-518a-5p 89-96 -0.475 99.0 -0.475 99.0 noncon
hsa-miR-6851-5p 26-33 -0.471 98.0 -0.471 99.0 noncon
hsa-miR-3689d 26-33 -0.385 98.0 -0.385 99.0 noncon
hsa-miR-6735-5p 71-77 -0.349 98.0 -0.349 98.0 noncon
hsa-miR-3616-3p 72-78 -0.309 94.0 -0.309 95.0 noncon
hsa-miR-6780a-5p 75-81 -0.303 95.0 -0.303 97.0 noncon
hsa-miR-6779-5p 75-81 -0.3 95.0 -0.3 96.0 noncon
hsa-miR-30b-3p 75-81 -0.289 94.0 -0.289 96.0 noncon
hsa-miR-150-3p 134-140 -0.285 91.0 0.0 11.0 noncon
hsa-miR-3689a-3p 75-81 -0.278 94.0 -0.278 96.0 noncon
hsa-miR-3689b-3p 75-81 -0.278 94.0 -0.278 96.0 noncon
hsa-miR-3689c 75-81 -0.278 94.0 -0.278 96.0 noncon
hsa-miR-1273h-5p 75-81 -0.278 93.0 -0.278 95.0 noncon
hsa-miR-4436b-3p 71-77 -0.272 95.0 -0.272 96.0 noncon
hsa-miR-7106-5p 75-81 -0.272 97.0 -0.272 97.0 noncon
hsa-miR-7847-3p 28-34 -0.27 92.0 -0.27 94.0 noncon
hsa-miR-6879-5p 71-77 -0.261 94.0 -0.261 95.0 noncon
hsa-miR-6871-5p 76-82 -0.26 94.0 -0.26 96.0 noncon