EnzFunc

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
DPM3



General Information
Gene Symbol:   
DPM3
Protein name:   
Dolichol-phosphate mannosyltransferase subunit 3
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

No reaction →
Reaction (IUBMB):   
No specified reaction.
About

• Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER

Related Pathway
KEGG ORTHOLOGY:   
K09659
KEGG Pathway:   
ko00510  ko01100 
Reactome:   
R-HSA-162699
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9P2X0 
NCBI GeneID:   
54344
GlyMap GeneID:   
54344
DNA aRefSeq:   
NM_018973.3 
Protein RefSeq:   
NP_061846.2 
BRENDA:   
Kinetic info.
OMIM number:   
605951
GeneCards database:   
DPM3
Enzyme Specificity
Glycan Type:  
     N-linked
Compartment:  
     ER
Substrate:  
     No reaction
Product:  
     
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 300 200 100 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
miRNA Name Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
hsa-miR-7106-5p 33-40 -0.816 99.0 -0.816 99.0 noncon
hsa-miR-149-5p 53-59 -0.625 99.0 -0.622 99.0 noncon
hsa-miR-376c-3p 111-118 -0.591 99.0 -0.012 40.0 noncon
hsa-miR-892b 54-60 -0.564 99.0 -0.562 99.0 noncon
hsa-miR-888-5p 82-89 -0.559 99.0 -0.014 45.0 noncon
hsa-miR-1273h-5p 34-40 -0.549 99.0 -0.549 99.0 noncon
hsa-miR-1307-5p 123-129 -0.543 94.0 -0.011 13.0 noncon
hsa-miR-23a-3p 136-143 -0.542 98.0 -0.011 50.0 noncon
hsa-miR-23b-3p 136-143 -0.542 98.0 -0.011 50.0 noncon
hsa-miR-23c 136-143 -0.542 98.0 -0.011 49.0 noncon
hsa-miR-130a-5p 136-143 -0.524 98.0 -0.011 51.0 noncon
hsa-miR-99a-5p 96-102 -0.52 97.0 -0.011 19.0 noncon
hsa-miR-100-5p 96-102 -0.52 97.0 -0.011 19.0 noncon
hsa-miR-99b-5p 96-102 -0.516 97.0 -0.011 19.0 noncon
hsa-miR-6779-5p 34-40 -0.516 99.0 -0.516 99.0 noncon
hsa-miR-30b-3p 34-40 -0.516 99.0 -0.516 99.0 noncon
hsa-miR-6780a-5p 34-40 -0.508 99.0 -0.508 99.0 noncon
hsa-miR-6871-5p 35-41 -0.502 99.0 -0.502 99.0 noncon
hsa-miR-3689a-3p 34-40 -0.483 99.0 -0.483 99.0 noncon
hsa-miR-3689b-3p 34-40 -0.483 99.0 -0.483 99.0 noncon
hsa-miR-3689c 34-40 -0.483 99.0 -0.483 99.0 noncon
hsa-miR-8057 52-58 -0.476 99.0 -0.474 99.0 noncon
hsa-miR-760 52-58 -0.465 98.0 -0.463 98.0 noncon
hsa-miR-6822-3p 52-58 -0.46 99.0 -0.458 99.0 noncon
hsa-miR-203a-5p 145-151 -0.446 98.0 -0.01 40.0 noncon
hsa-miR-587 88-95 -0.446 99.0 -0.01 47.0 noncon
hsa-miR-4446-3p 26-32 -0.438 98.0 -0.438 99.0 noncon
hsa-miR-149-3p 34-40 -0.431 99.0 -0.431 99.0 noncon
hsa-miR-876-3p 146-152 -0.425 98.0 -0.009 35.0 noncon
hsa-miR-4506 44-50 -0.414 98.0 -0.412 99.0 noncon
hsa-miR-4741 25-31 -0.413 99.0 -0.413 99.0 noncon
hsa-miR-6878-3p 158-164 -0.41 98.0 -0.009 49.0 noncon
hsa-miR-4668-5p 41-47 -0.401 99.0 -0.401 99.0 noncon
hsa-miR-3202 29-35 -0.394 98.0 -0.394 99.0 noncon
hsa-miR-766-5p 32-38 -0.388 98.0 -0.388 98.0 noncon
hsa-miR-6799-5p 34-40 -0.367 99.0 -0.367 99.0 noncon
hsa-miR-516a-5p 126-132 -0.362 96.0 -0.008 31.0 noncon
hsa-miR-6883-5p 34-40 -0.359 98.0 -0.359 98.0 noncon
hsa-miR-4728-5p 34-40 -0.358 98.0 -0.358 98.0 noncon
hsa-miR-5093 39-45 -0.357 99.0 -0.357 99.0 noncon
hsa-miR-4675 25-31 -0.343 99.0 -0.343 99.0 noncon
hsa-miR-152-5p 144-150 -0.341 96.0 -0.008 34.0 noncon
hsa-miR-6785-5p 34-40 -0.334 97.0 -0.334 98.0 noncon
hsa-miR-6739-5p 41-47 -0.328 98.0 -0.328 99.0 noncon
hsa-miR-4476 30-36 -0.32 98.0 -0.32 99.0 noncon
hsa-miR-6876-5p 30-36 -0.32 98.0 -0.32 99.0 noncon
hsa-miR-371a-5p 81-87 -0.312 99.0 -0.009 68.0 noncon
hsa-miR-323b-3p 100-106 -0.311 98.0 -0.007 53.0 noncon
hsa-miR-3153 41-47 -0.31 99.0 -0.31 99.0 noncon
hsa-miR-182-3p 144-150 -0.309 97.0 -0.007 29.0 noncon
hsa-miR-6733-5p 41-47 -0.28 97.0 -0.28 98.0 noncon
hsa-miR-4670-3p 69-75 -0.276 97.0 -0.008 37.0 noncon
hsa-miR-181c-5p 134-140 -0.273 96.0 -0.006 38.0 noncon
hsa-miR-4757-5p 158-164 -0.273 95.0 -0.006 39.0 noncon
hsa-miR-548g-3p 57-63 -0.272 98.0 -0.271 99.0 noncon
hsa-miR-181d-5p 134-140 -0.262 96.0 -0.006 37.0 noncon
hsa-miR-181a-5p 134-140 -0.262 96.0 -0.006 37.0 noncon
hsa-miR-181b-5p 134-140 -0.262 96.0 -0.006 37.0 noncon
hsa-miR-6793-3p 103-109 -0.257 96.0 -0.006 51.0 noncon