GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
UGT1A3



General Information
Gene Symbol:   
UGT1A3
Protein name:   
UDP-glucuronosyltransferase 1A3
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
GT1
E.C. No:   
2.4.1.17
Tissues:   
Muscular, Epithelial, Connective, Nervous
Organs:   
Reaction (SNFG):   
+ R →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• UGTs are glucuronyltransferases involved in the glucuronidation pathway. This involves the addition of glucuronic acid to excretables such as bilirubin, xenobiotics, and drugs. Substrates tend to be lipophilic in nature.
• Glucuronidation is often involved in drug metabolism of substances such as drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids, and bile acids.

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-156588
Related Database
Organism:   
Homo sapiens
Uniprot:   
P35503 
NCBI GeneID:   
54659
GlyMap GeneID:   
54659
DNA aRefSeq:   
NM_019093.2 
Protein RefSeq:   
NP_061966.1 
BRENDA:   
Kinetic info.
OMIM number:   
191740
GeneCards database:   
UGT1A3
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     R
Product:  
     GlcA(??-?)R
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 240 220 200 180 160 140 120 100 80 60 40 20 0 RPKM
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000482026 CLOCK HNF1B ZBTB33 JUND ATF3 HNF4A YY1
miRNA-GlycoEnzyme Interactome {ref. 9}
UGT1A3/hsa-miR-6736-3p
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...GCUUAUGUCAAAU GGAGCUGA ...
3'   GACACCCAUCUCU CCUCGAC U
 8mer 629-636 -0.52 99.0 -0.52 99.0 noncon