Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
---|
Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
---|
|
+ |
|
→ |
|
+ | CMP |
• ST3Gal6 has high specificity for neolactotetraosylceramide (paragloboside, nLc4) and neolactohexaosylceramide (nLc6) as glycosphingolipid substrates.
• It shows preference for Gal1β,4GlcNAc and less for Galβ1,3GlcNAc.
• ST3Gal6 might have distinct role especially in the regulation of the synthesis of sialyl type II lactosamine on glycolipids. Preference on glycoproteins is under study. Enzyme can contribute to sLeX biosynthesis.
ER | Cis- | Medial- | Trans- | TGN |
---|---|---|---|---|
|
|
|
|
|
ST3GAL6/hsa-miR-7974 |
---|
miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'... UUCCCCUCAUACCA
CACAGCCA
...
3' CCCGAGUCCUCUCGUA GUGUCGG A |
8mer | 1772-1779 | -0.327 | 95.0 | -0.013 | 35.0 | noncon | |
5'... CCUAAGAUCAAGUA
ACAGCCA
A...
3' CCCGAGUCCUCUCGUAG UGUCGG A |
7mer-A1 | 3032-3038 | -0.139 | 69.0 | -0.001 | 21.0 | noncon |