GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
SLC35D1



General Information
Gene Symbol:   
SLC35D1
Protein name:   
UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter
Enzyme Class:   
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

UDP-GlcA [cyto] or UDP-GalNAc [cyto] or UDP-GlcA [cyto] or UDP-GalNAc [cyto] → UDP-GlcA [ER] or UDP-GalNAc [ER] or UDP-GlcA [Golgi] or UDP-GalNAc [Golgi]
Reaction (IUBMB):   
No specified reaction.
About

• UDP-GalNAc & UDP-GlcA transporter

Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
No Record 
Reactome:   
R-HSA-173599
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q9NTN3 
NCBI GeneID:   
23169
GlyMap GeneID:   
23169
DNA aRefSeq:   
NM_015139.2 
Protein RefSeq:   
NP_055954.1 
BRENDA:   
Kinetic info.
OMIM number:   
610804
GeneCards database:   
SLC35D1
Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     UDP-GlcA [cyto] or UDP-GalNAc [cyto] or UDP-GlcA [cyto] or UDP-GalNAc [cyto]
Product:  
     UDP-GlcA [ER] or UDP-GalNAc [ER] or UDP-GlcA [Golgi] or UDP-GalNAc [Golgi]
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000235345 AR ZNF770 HLF SOX2 TAL1 IKZF1 PPARG ASCL1 SMARCE1 PRDM6 HMG20A MAFK FEZF1 TCF3 RUNX1 SCRT1 NFIL3 GATAD2A ZNF324 ZNF263 NR2F6 REST NFE2 KLF9 KLF9 GLIS1 EBF1 SMAD4 NRF1 ZNF574 KLF4 KLF4 RCOR1 ZSCAN22 CREB1 MAZ PATZ1 PATZ1 POU5F1 POU5F1 SMAD2 SOX2 ARNT VEZF1 NFYA NFKB1 ZBTB14 MYCN EOMES FOSL1 E2F6 CEBPB FOXP1 MAX ZBTB26 ATF1 CREB1 CREB1 MEIS2 MEIS2 E2F1 ZBTB2 ZBTB2 RUNX3 ZBTB16 YY1 MAF SMAD5 NFE2 NFE2 SMARCC1 TBX5 MAX ERG ATF2 NR2F2 SOX2 ZBTB17 ZBTB17 ZKSCAN8 REST JUNB JUNB KDM5C SMAD1 MAX TEAD1 HMG20A GATAD2A NFYC NFYC HOMEZ ZBTB11 TFAP2C ZBTB20 ZBTB20 ZBTB20 RXRB GATA2 ZNF652 SOX5 SP3 RCOR1 DMAP1 NR2F6 ARID4B TBX3 ZNF335 ZNF335 ZNF335 KAT8 HMG20B HMG20B RCOR2 RCOR2 RCOR2 NFIA NFIA NR2F2 NR2F2 NR2F2 NR2F2 SMAD4 TCF12 CEBPG CEBPG CEBPG CEBPG THAP11 THAP11 NR2F1 NR2F1 ZNF18 GLIS1 TAL1 TAL1 TAL1 ZNF48 HNF4G HNF4G HNF4G TEAD4 TEAD4 BACH1 CREB1 RFXANK MITF PPARG MXD4 MXD4 SP5 ZBTB26 ZNF792 ZNF792 SP4 SP4 SP2 IRF1 USF2 KLF12 BCL6 ZNF391 ZNF391 KLF15 FOSL2 ZIC2 ZFP64 NONO KLF9 KLF4 E2F4 E2F6 IKZF1 IKZF1 ZNF618 TCF7L1 PAX5 TFAP4 MAZ ZBTB26 APC ZBTB18
miRNA-GlycoEnzyme Interactome {ref. 9}
SLC35D1/hsa-miR-4768-5p
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...UAAAAUUUUAUGAA GAGAGAAA ...
3'   UAGGUACCCUAGGU CUCUCUU A
 8mer 165-172 -0.33 97.0 -0.327 97.0 noncon
5'...AGAAAACAAAACUC AGAGAAA G...
3'   UAGGUACCCUAGGUC UCUCUU A
 7mer-A1 1868-1874 -0.01 38.0 -0.002 48.0 noncon