Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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ManNAc(6P) or Man(6P) | → | Neu5Ac or Kdn |
• N-acetylneuraminic acid phosphate synthase reacts with mannosamine and phosphoenolpyruvate to form Neuraminic acids. It plays a crucial role in the biosynthesis of sialic acids in humans.
• NANS is essential for sialic acid development as the recycling rate of sialic acids in humans is low.
• NANS has been reported to create sialic acid KDN in some cancer contexts.
• Deficiency in NANS activity has been linked to Down?s syndrome, and delays in neurological development.
ER | Cis- | Medial- | Trans- | TGN |
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NANS/hsa-miR-6750-5p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'... UCUCUGAAUUCUCA
GUUCCCU
U...
3' UCGUCGAGUGGGUCGA CAAGGGA C |
7mer-m8 | 29-35 | -0.521 | 99.0 | 0.0 | 44.0 | noncon |