Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
---|
Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
---|
|
→ |
|
• Iduronic acid sulfatase removes sulfate from iduronic acid on the 2 carbon. Involved in the biosynthesis of dermatan and heparan sulfates.
• Mutations in this gene results in Hunter's Syndrome, which causes accumulation of glycosaminoglycans in the body. The disease manifests early in life and causes a wide array of bodily dysregulation such as joint stiffness, cognitive impairment and neurodegeneration.
ER | Cis- | Medial- | Trans- | TGN |
---|---|---|---|---|
|
|
|
|
|
IDS/hsa-miR-6791-3p |
---|
miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...CAUGUAUUUAUUC
AGGAGGCA
...
3' GACGGCCUCUGGU UCCUCCG U |
8mer | 909-916 | -0.358 | 98.0 | -0.325 | 98.0 | noncon | |
5'...CAUGUAUUUAUUC
AGGAGGCA
...
3' GACGGCCUCUGGU UCCUCCG U |
8mer | 909-916 | -0.314 | 97.0 | -0.287 | 98.0 | noncon | |
5'...CCCCCCCUCCCGA
AGGAGGC
U...
3' GACGGCCUCUGGU UCCUCCG U |
7mer-m8 | 2771-2777 | -0.039 | 58.0 | -0.036 | 71.0 | noncon | |
5'...AUUGCUUGAACCC
AGGAGGC
G...
3' GACGGCCUCUGGU UCCUCCG U |
7mer-m8 | 3635-3641 | -0.037 | 57.0 | -0.019 | 59.0 | noncon | |
5'...CCCCCCCUCCCGA
AGGAGGC
U...
3' GACGGCCUCUGGU UCCUCCG U |
7mer-m8 | 2771-2777 | -0.02 | 37.0 | -0.018 | 58.0 | noncon | |
5'...AUUGCUUGAACCC
AGGAGGC
G...
3' GACGGCCUCUGGU UCCUCCG U |
7mer-m8 | 3635-3641 | -0.02 | 37.0 | -0.01 | 51.0 | noncon |