Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ |
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→ |
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+ | UDP |
• This is C2GnT-3 or C2GnT-T (Thymus type), It is highly expressed in thymus but not in other tissue.
• C2GnT-3 deficiency altered behavior linked to reduced thyroxine levels in circulation.
• The enzyme mediates core 2 O-glycan branching, and is important for mucin-biosynthesis.
• Does not have core 4 O-glycan or I-branching enzyme activity
ER | Cis- | Medial- | Trans- | TGN |
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GCNT4/hsa-miR-676-3p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...AUCUAGCCCAAAA
UAGGACAA
...
3' UUGAGUUGUUGGA AUCCUGU C |
8mer | 1624-1631 | -0.258 | 96.0 | -0.185 | 93.0 | noncon |