GlyClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 
Pathway Map
GALNT6



General Information
Gene Symbol:   
GALNT6
Protein name:   
Polypeptide N-acetylgalactosaminyltransferase 6
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
CBM13
E.C. No:   
2.4.1.41
Organs:   
Reaction (SNFG):   
+ Ser →
+ UDP
+ Thr →
+ UDP
Reaction (IUBMB):   
No specified reaction.
About

• GALNT6 may participate in synthesis of oncofetal fibronectin.

Related Pathway
KEGG ORTHOLOGY:   
K00710
KEGG Pathway:   
ko00512  ko01100 
Reactome:   
R-HSA-913709
Related Database
Organism:   
Homo sapiens
Uniprot:   
Q8NCL4 
NCBI GeneID:   
11226
GlyMap GeneID:   
11226
DNA aRefSeq:   
NM_007210.3 
Protein RefSeq:   
NP_009141.2 
BRENDA:   
Kinetic info.
OMIM number:   
605148
GeneCards database:   
GALNT6
Enzyme Specificity
Glycan Type:  
     O-linked (mucin type)
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     Ser or Thr
Product:  
     GalNAc(a1-?)Ser or GalNAc(a1-?)Thr
Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN










Expression Data in Tissue {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 30 20 10 0 RPKM
Expression Data in Cells {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)
Transcription factor {ref. 10}
Transcriptional start site (TSS) 0 200 -2000 -1800 -1600 -1400 -1200 -1000 -800 -600 -400 -200
ENST00000356317 ENST00000543196 ENST00000603641 RUNX1 RUNX2 ZNF92 ZBTB48 MAX ZNF121 MYC TAL1 ZIM3 ZNF770 FLI1 RUNX1 ATF2 NFE2 ZNF140 RUNX1 KLF5 E2F1 HNF1B TEAD1 IRF1 IRF4 BATF BATF NR5A2 RUNX3 TBX21 TCF3 ETS1 TCF4 IKZF1 TFAP2C STAT5A MECOM MAX ZEB2 BCL11B NFE2 MAX
miRNA-GlycoEnzyme Interactome {ref. 9}
GALNT6/hsa-miR-6775-3p
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...AAGAAAGGAAAAA CAGGGCCA ...
3'   GACCCCGUCUCCU GUCCCGG A
 8mer 1711-1718 -0.354 95.0 -0.354 96.0 noncon
5'...AUAGGAAAACAGC CAGGGCC G...
3'   GACCCCGUCUCCU GUCCCGG A
 7mer-m8 1405-1411 -0.02 16.0 -0.02 36.0 noncon