Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ | Dol-P | → |
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+ | GDP |
• Transfers mannose from GDP-Man to dolichol monophosphate (Dol-P) to Dol-P-Man.
• Dol-P-Man acts as a mannosyl donor in N-glycosylation, GPI, and O-mannosylation pathways.
• This is the catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex, that also includes DPM2 and DPM3
ER | Cis- | Medial- | Trans- | TGN |
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DPM1/hsa-miR-200b-5p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...AAUUGAUCUCAGAA
GUAAGAUA
...
3' AGGUUACGACGGGU CAUUCUA C |
8mer | 378-385 | -0.365 | 99.0 | -0.005 | 58.0 | noncon | |
5'...AAUUAGUUUUAAGC
UAAGAUA
A...
3' AGGUUACGACGGGUC AUUCUA C |
7mer-A1 | 1723-1729 | -0.01 | 46.0 | 0.0 | 43.0 | noncon |