FuncClass

GlycoEnzDB
Comprehensive glycoEnzyme database and dynamic pathway generation

Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).

GlycoEnzDB
Create glycosylation pathway
Custom database generation
Instructions/Reference
 

Pathway Map

COLGALT1



General Information
Gene Symbol:   
COLGALT1
Protein name:   
Procollagen galactosyltransferase 1
Enzyme Class:   
Glycosyltransferase
CAZy Family:   
E.C. No:   
Organs:   
Reaction (SNFG):   

5-hydroxy-L-lysyl- Gal(b1-?)-5-hydroxy-L-lysyl-
Reaction (IUBMB):   
No specified reaction.

About

• Widely expressed (α1-2)GalT that modifies 5-hydroxy-L-lysyl- on collagen and collagen-like domains
• This is an ER resident enzyme involved in the biosynthesis of collagen type IV
• Glycosylation occurs before the formation of the collagen triple helix
• Compared to COLGALT1, COLGALT2 is only expressed at lower levels in the nervous system
• The product of COLGALT1/2 is modified by glucose, though the enzyme mediating this feature is yet unknown


Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
Reactome:   

Related Database
Organism:   
Homo sapiens
Uniprot:   
NCBI GeneID:   
GlyMap GeneID:   
DNA aRefSeq:   
Protein RefSeq:   
BRENDA:   
OMIM number:   
GeneCards database:   

Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     5-hydroxy-L-lysyl-
Product:  
     Gal(b1-?)-5-hydroxy-L-lysyl-

Simulation Parameters
Mechaelis-Menten parameters (suggested)
VM:       (pmol/cell • hr)       KM:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN











Expression Data in Tissue {ref. 5} Source from NCBI gene database
No expression data available.
Expression Data in Cells
No expression data available.
Transcription factor {ref. 10}
No high degree of confidence data