Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
---|
Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
---|
|
+ |
|
→ |
|
+ | UDP |
• Alg13/Alg14 are part of a heterodimer that transfers second GlcNAc from UDP-GlcNAc to generate Dol-PP-GlcNAc2
• Cells lacking these activities grow slowly, and mutations in Alg13 leads to CDG-1r
ER | Cis- | Medial- | Trans- | TGN |
---|---|---|---|---|
|
|
|
|
|
ALG14/hsa-miR-4420 |
---|
miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...AAUGUACAGAUGAC
UCAGUGAA
...
3' GAGUCGAUGUCUGU AGUCACU G |
8mer | 148-155 | -0.449 | 99.0 | -0.446 | 99.0 | noncon | |
5'...UGGCCUGCAUGCAG
CAGUGAA
A...
3' GAGUCGAUGUCUGUA GUCACU G |
7mer-A1 | 8523-8529 | -0.032 | 70.0 | 0.0 | 43.0 | noncon | |
5'...AACAGUGAUGUCCC
CAGUGAA
U...
3' GAGUCGAUGUCUGUA GUCACU G |
7mer-A1 | 479-485 | -0.027 | 65.0 | -0.001 | 45.0 | noncon | |
5'...UCCUCUUUAGUCAG
UCAGUGA
U...
3' GAGUCGAUGUCUGU AGUCACU G |
7mer-m8 | 5897-5903 | -0.02 | 53.0 | 0.0 | 42.0 | noncon | |
5'...GGAGGUGGAGGUUG
CAGUGAA
C...
3' GAGUCGAUGUCUGUA GUCACU G |
7mer-A1 | 4935-4941 | -0.01 | 42.0 | 0.0 | 40.0 | noncon |