Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ |
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→ |
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+ | UDP |
• Alg13/Alg14 are part of a heterodimer that transfers second GlcNAc from UDP-GlcNAc to generate Dol-PP-GlcNAc2
• Cells lacking these activities grow slowly, and mutations in Alg13 leads to CDG-1r
ER | Cis- | Medial- | Trans- | TGN |
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ALG14/hsa-miR-181b-3p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
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5'...AUGUACAGAUGAC
UCAGUGAA
...
3' AACGUAAGUAACA AGUCACU C |
8mer | 148-155 | -0.482 | 99.0 | -0.479 | 99.0 | noncon | |
5'...GGCCUGCAUGCAG
CAGUGAA
A...
3' AACGUAAGUAACAA GUCACU C |
7mer-A1 | 8523-8529 | -0.095 | 78.0 | -0.001 | 37.0 | noncon | |
5'...ACAGUGAUGUCCC
CAGUGAA
U...
3' AACGUAAGUAACAA GUCACU C |
7mer-A1 | 479-485 | -0.066 | 71.0 | -0.002 | 40.0 | noncon | |
5'...CCUCUUUAGUCAG
UCAGUGA
U...
3' AACGUAAGUAACA AGUCACU C |
7mer-m8 | 5897-5903 | -0.021 | 48.0 | 0.0 | 33.0 | noncon | |
5'...GAGGUGGAGGUUG
CAGUGAA
C...
3' AACGUAAGUAACAA GUCACU C |
7mer-A1 | 4935-4941 | -0.01 | 34.0 | 0.0 | 32.0 | noncon |