Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (neel@buffalo.edu), Yusen Zhou (yusenzho@buffalo.edu) or Ted Groth (tgroth@buffalo.edu).
Pathway figs |
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Glycosylation |
Sugar Nucleotide |
Glucuronidation |
Glycan Degradation |
Pathway Map |
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+ |
|
→ |
|
+ | P-Dol |
• Dol-P-Glc is formed from UDP-Glc using ALG5
• Three Glc residues are then transferred from Dol-P-Glc to the LLO using ER-resident ALG6 [α(1,3)GlcT], ALG8 [α(1,3)GlcT] and ALG10 [α(1,2)GlcT].
ER | Cis- | Medial- | Trans- | TGN |
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ALG10/hsa-miR-5007-3p |
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miRNA Target | Site Type | Pos. | Context Score | Frac. | Wt. Context | Frac. | Conserved | Quality |
---|---|---|---|---|---|---|---|---|
5'...AUAAAAUAUUUAUU
CAUAUGAA
...
3' UAAUCUCAAACCAA GUAUACU A |
8mer | 1584-1591 | -0.278 | 98.0 | 0.0 | 27.0 | noncon | |
5'...AGACCUUUGUUUUA
AUAUGAA
U...
3' UAAUCUCAAACCAAG UAUACU A |
7mer-A1 | 5295-5301 | -0.136 | 88.0 | 0.0 | 27.0 | noncon | |
5'...GAUAUAUGUUGUAA
AUAUGAA
U...
3' UAAUCUCAAACCAAG UAUACU A |
7mer-A1 | 5208-5214 | -0.134 | 87.0 | 0.0 | 27.0 | noncon | |
5'...CAUAAUAUUUAUGU
CAUAUGA
U...
3' UAAUCUCAAACCAA GUAUACU A |
7mer-m8 | 1945-1951 | -0.128 | 86.0 | 0.0 | 27.0 | noncon | |
5'...UGGCAUACUUCAUU
CAUAUGA
C...
3' UAAUCUCAAACCAA GUAUACU A |
7mer-m8 | 4727-4733 | -0.11 | 82.0 | 0.0 | 27.0 | noncon | |
5'...CUAAUAUAUCUUCC
CAUAUGA
U...
3' UAAUCUCAAACCAA GUAUACU A |
7mer-m8 | 4691-4697 | -0.082 | 74.0 | 0.0 | 0.0 | noncon |