GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
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SLC35B3



General Information
Gene Symbol:   
SLC35B3
Protein name:   
Adenosine 3'-phospho 5'-phosphosulfate transporter 2
Enzyme Class:   
CAZy Family:   
E.C. No:   
Reaction (SNFG):   

PAPS [Cyto] PAPS [Golgi]
Reaction (IUBMB):   
No specified reaction.

About

* SLC35B2 and B3 transfer PAPS from the cytosol into the Golgi apparatus from the cytoplasm.
* PAPS is a universal sulfuryl donor for sulfation
* Depending on cancer type, the expression of PAPST1 and PAPST2 can increase or decrease, resulting in increases or decreases in sulfation of GAGs, respectively.
* Decreased expression of PAPST1 and PAPST2 caused FGF signaling to decrease in colorectal cells.


Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
Reactome:   

Related Database
Organism:   
Homo sapiens
Uniprot:   
NCBI GeneID:   
GlyMap GeneID:   
DNA_RefSeq:   
Protein_RefSeq:   
BRENDA:   
OMIM number:   
GeneCards database:   

Enzyme Specificity
Glycan Type:  
     
Compartment:  
     Cis, Medial, Trans, TGN
Substrate:  
     PAPS [Cyto](-CHAR)
Product:  
     PAPS [Golgi](-CHAR)

Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN











Expression Data {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 12 10 8 6 4 2 0 RPKM
Expression data are collected from NCBI gene database

Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 30 20 10 0 Transcripts per million (TPM)

Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
SLC35B3/hsa-miR-374a-3p
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'...ACUUUCCAAAGGGA CUGAUAAA ...
3'   UUAAUGUUAUGUUA GACUAUU C
8mer 70-77 -0.342 99.0 -0.342 99.0 noncon
5'...CUUUCUCAAAUCUU UGAUAAA A...
3'   UUAAUGUUAUGUUAG ACUAUU C
7mer-A1 2081-2087 -0.113 85.0 -0.025 69.0 noncon