GlycoEnzDB

General Information

Gene Symbol:

PIGM

Protein name:

GPI mannosyltransferase 1

Enzyme Class:

Glycosyltransferase

CAZy Family:

GT50

E.C. No:

2.4.1.*

Reaction (SNFG):

GlcN(a1-6)(ancyl)PI

→

Man(a1-4)GlcN(a1-6)(ancyl)PI

Reaction (IUBMB):

No specified reaction.

About

* PIGM together with PIGX mediated transfer of the first Man from Dol-P (donor) during GPI-protein synthesis.
* Here, PIGM has catalytic activity while PIGX has regulatory function.

Related Pathway

KEGG ORTHOLOGY:

K05284

KEGG Pathway:

ko00563 ko01100

Reactome:

R-HSA-162710

Related Database

Organism:

Homo sapiens

Uniprot:

Q9H3S5

NCBI GeneID:

93183

GlyMap GeneID:

93183

DNA_RefSeq:

NM_145167.2

Protein_RefSeq:

NP_660150.1

BRENDA:

Kinetic info.

OMIM number:

610273

GeneCards database:

PIGM

Enzyme Specificity

Glycan Type:

GPI

Compartment:

ER

Substrate:

GlcN(a1-6)(ancyl)PI(-CHAR)

Product:

Man(a1-4)GlcN(a1-6)(ancyl)PI(-CHAR)

Simulation Parameters

Mechaelis-Menten parameters (suggested)
Vm: (pmol/cell • hr) Km: (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)

ER	Cis-	Medial-	Trans-	TGN

No expression data available.

Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database

Transcription factor {ref. 10}

No high degree of confidence data

miRNA-GlycoEnzyme Interactome {ref. 9}

PIGM/hsa-miR-3171

miRNA Target	Site Type	Pos.	Context Score	Frac.	Wt. Context	Frac.	Conserved	Quality
5'... UAUUCACAUUAUAA AUACAUCA ... 3' CUAUAUAUGUCUAAGG UAUGUAG A	8mer	2381-2388	-0.255	92.0	-0.174	89.0	noncon