GlycoEnzDB
The Comprehensive Glyco-enzyme Database
GlycoEnzDB
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Instructions/Reference
GMPPA



General Information
Gene Symbol:   
GMPPA
Protein name:   
Mannose-1-phosphate guanyltransferase alpha
Enzyme Class:   
N_linked
CAZy Family:   
E.C. No:   
Tissues:   
all, Muscular, Epithelial, Connective, Nervous
Organs:   
Musculoskeletal, Pancreas, Bladder, Spleen, Mouth, Liver, Ovaries, Brain, Stomach, Lungs, Prostate, Eyes, Intestines, Kidney, Heart
Reaction (SNFG):   

Man(1P) GDP-Man
Reaction (IUBMB):   
No specified reaction.

About

* Synthesizes GDP-mannose from mannose 1 phosphate and GTP.
* Knowledge of GMPPA and B is subsumed based on porcupine enzyme activity and the homology of porcupine and GMPPA and B structures.
* GDP-mannose is a critical reactant for sugar nucleotide synthesis and glycosylation, as it can be directly used in the synthesis of N-linked glycans and can be metabolized into other sugar nucleotide donors.


Related Pathway
KEGG ORTHOLOGY:   
KEGG Pathway:   
Reactome:   

Related Database
Organism:   
Homo sapiens
Uniprot:   
NCBI GeneID:   
GlyMap GeneID:   
DNA_RefSeq:   
Protein_RefSeq:   
BRENDA:   
OMIM number:   
GeneCards database:   

Enzyme Specificity
Glycan Type:  
     
Compartment:  
     
Substrate:  
     Man(1P)(-CHAR)
Product:  
     GDP-Man(-CHAR)
Constraints:  
     None

Simulation Parameters
Mechaelis-Menten parameters (suggested)
Vm:       (pmol/cell • hr)       Km:       (pM)
Relative conc of enzymes in compartment.(sum will be normalized to 1)
ER Cis- Medial- Trans- TGN











Expression Data {ref. 5} Source from NCBI gene database
adrenal appendix bone marrow brain colon duodenum endometrium esophagus fat gall bladder heart kidney liver lung lymph node ovary pancreas placenta prostate salivary gland skin small intestine spleen stomach testis thyroid urinary bladder 20 10 0 RPKM
Expression data are collected from NCBI gene database

Cancer Cell Line Encyclopedia {ref. 13} Source from Cancer Cell Line Encyclopedia database
Kidney Lung Breast Prostate Large intestine Ovary HL60 haematopoietic and lymphoid tissue Skin Central nervous system 786O A498 ACHN CAKI1 UO31 A549 EKVX HOP62 HOP92 NCIH226 NCIH23 NCIH322 NCIH460 NCIH522 SHP77 BT549 HS578T MCF7 MDAMB231 MDAMB468 T47D DU145 PC3 HCT116 HCT15 HT29 KM12 SW620 OVCAR4 OVCAR8 IGROV1 SKOV3 HL60 K562 RPMI8226 LOXIMVI MALME3M RPMI7951 SKMEL28 SKMEL5 UACC257 UACC62 SF268 SF295 SF539 SNB75 120 100 80 60 40 20 0 Transcripts per million (TPM)

Transcription factor {ref. 10}
No high degree of confidence data
miRNA-GlycoEnzyme Interactome {ref. 9}
GMPPA/hsa-miR-637
miRNA Target Site Type Pos. Context Score Frac. Wt. Context Frac. Conserved Quality
5'... GGGCUGCCAGAAGG CCCCCAG C...
3'   UGCGUCUCGGGCUUUC GGGGGUC A
7mer-m8 18-24 -0.286 95.0 -0.286 96.0 noncon