Description: The GlycoEnzDB is a manually curated glycoEnzyme database, primarily focused on humans. It covers 390 enzymes across 28 pathway maps. Facilities are also available to create custom glycosylation reaction pathways using experimental data in SBML format and for pathway simulation
Contacts: Sriram Neelamegham (email@example.com), Yusen Zhou (firstname.lastname@example.org) or Ted Groth (email@example.com).
• UGGT is a large soluble protein that is mostly ER retained.
• This is the glycoprotein folding sensor enzyme. If the glycoprotein is incompletely folded, the misfolded protein is recognized in the context of its N-glycan by the folding sensor UGGT. UGGT puts back one α(1-3)Glc, and refolding is again attempted by CNX/CRT.
• Proteins unable to properly fold after multiple cycles are eventually retro-translocated to the cytosol to be degraded by the proteasome, a process known as endoplasmic reticulum-associated degradation (ERAD).
• It is currently thought that the N-terminal may bind the misfolded polypeptide, while the C-terminal performs glycosyltransferase activity. In humans there are two proteins mediating this enzyme activity.
• Although extensively distributed in nature, UGGT is not required for single cell viability under normal conditions.